alterlab-deeptools

alterlab-deeptools is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 173 tokens per session (3,476 once invoked), scanned A, original, MIT.

A command-line toolkit for processing and visualizing sequencing coverage from experiments such as ChIP-seq, RNA-seq, and ATAC-seq. It works with BAM alignment files and produces tracks, comparisons, quality checks, heatmaps, and profiles.

In plain words
What is it for?
Use it to convert BAM files to bigWig tracks, compare samples, assess correlations and sequencing quality, apply the ATAC-seq alignment shift, and plot signal around transcription start sites or peaks.
Why use it?
It turns raw aligned sequencing reads into standardized coverage and visual summaries. This makes it easier to check sample quality, compare conditions, and see signal around genes or other genomic regions.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Part of the alterlab-bioinformatics plugin — 38 skills shipped together

Good fit Use it to convert BAM files to bigWig tracks, compare samples, assess correlations and sequencing quality, apply the ATAC-seq alignment shift, and plot signal around transcription start sites or peaks.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-deeptools
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-deeptools
Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills

Made for: Claude Code.

Or install alterlab-bioinformatics, the plugin that ships this one along with the rest of its 38 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-deeptools

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-deeptools/github.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-deeptools)
Your own site
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-deeptools"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-deeptools/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for alterlab-deeptools

Your own site · 80×15
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-deeptools"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-deeptools.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 173 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,476 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00173 $0.03476
Opus 5 $0.00086 $0.01738
Sonnet 5 $0.00035 $0.00695
Haiku 4.5 $0.00017 $0.00348

Measured 10d ago against content hash ec1564a23cb0, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-09, from the pricing page.

Security

Grade A, and why

alterlab-deeptools scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 10d ago.

The scan reads SKILL.md. This mod also ships 2 executable files (scripts/validate_files.py, scripts/workflow_generator.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/bioinformatics/alterlab-deeptools/SKILL.md · 360 lines

How it starts

The opening of the file, as written. The whole thing — 360 lines — stays where its author put it; the contents beside it link to each section on GitHub.

deepTools: NGS Data Analysis Toolkit

Overview

deepTools is a comprehensive suite of Python command-line tools designed for processing and analyzing high-throughput sequencing data. Use deepTools to perform quality control, normalize data, compare samples, and generate publication-quality visualizations for ChIP-seq, RNA-seq, ATAC-seq, MNase-seq, and other NGS experiments.

Core capabilities:

  • Convert BAM alignments to normalized coverage tracks (bigWig/bedGraph)
  • Quality control assessment (fingerprint, correlation, coverage)
  • Sample comparison and correlation analysis
  • Heatmap and profile plot generation around genomic features
  • Enrichment analysis and peak region visualization

When to Use This Skill

This skill should be used when:

  • File conversion: "Convert BAM to bigWig", "generate coverage tracks", "normalize ChIP-seq data"
  • Quality control: "check ChIP quality", "compare replicates", "assess sequencing depth", "QC analysis"
  • Visualization: "create heatmap around TSS", "plot ChIP signal", "visualize enrichment", "generate profile plot"
  • Sample comparison: "compare treatment vs control", "correlate samples", "PCA analysis"
  • Analysis workflows: "analyze ChIP-seq data", "RNA-seq coverage", "ATAC-seq analysis", "complete workflow"
  • Working with specific file types: BAM files, bigWig files, BED region files in genomics context

Quick Start

For users new to deepTools, start with file validation and common workflows:

1. Validate Input Files

Before running any analysis, validate BAM, bigWig, and BED files using the validation script:

python scripts/validate_files.py --bam sample1.bam sample2.bam --bed regions.bed

This checks file existence, BAM indices, and format correctness.

2. Generate Workflow Template

For standard analyses, use the workflow generator to create customized scripts:

# List available workflows
python scripts/workflow_generator.py --list

# Generate ChIP-seq QC workflow
python scripts/workflow_generator.py chipseq_qc -o qc_workflow.sh \
    --input-bam Input.bam --chip-bams "ChIP1.bam ChIP2.bam" \
    --genome-size 2913022398

# Make executable and run
chmod +x qc_workflow.sh
./qc_workflow.sh

Read the full file on GitHub · 360 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 10d ago First seen · 360 lines · 173 tokens per session scan A ec1564a23cb0

Subscribe to this mod's changes

alterlab-deeptools is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (66 stars, last pushed 5d ago), licensed MIT. It adds 173 tokens to every session and 3,476 once invoked, about $0.0009 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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