alterlab-hypogenic

alterlab-hypogenic is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 90 tokens per session (3,177 once invoked), scanned A, original, MIT.

A tool that uses language models and datasets to propose and test research hypotheses. A hypothesis is a testable explanation for a pattern in data.

In plain words
What is it for?
Use it to generate hypotheses, refine them with literature and data, and run inference on the proposed explanations.
Why use it?
It helps researchers explore possible explanations by combining information from published literature with patterns found in tabular data.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Needs its repository: it runs a file that does not travel with it, so clone the repository first. The line is bash ./modules/setup_grobid.sh.

Part of the alterlab-domain-specific plugin — 18 skills shipped together

Good fit Use it to generate hypotheses, refine them with literature and data, and run inference on the proposed explanations.

Compare 6 skills from other repositories ↓
Install

Getting it into your agent

It runs from inside its repository, so the clone comes first — what it calls does not travel with the file alone.

Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills
agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-hypogenic

Made for: Claude Code.

Or install alterlab-domain-specific, the plugin that ships this one along with the rest of its 18 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-hypogenic

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-hypogenic/github.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-hypogenic)
Your own site
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Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for alterlab-hypogenic

Your own site · 80×15
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Per session 90 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,177 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00090 $0.03177
Opus 5 $0.00045 $0.01588
Sonnet 5 $0.00018 $0.00635
Haiku 4.5 $0.00009 $0.00318

Measured 5d ago against content hash e8d714c4f79c, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-10, from the pricing page.

Security

Grade A, and why

alterlab-hypogenic scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 5d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/domain-specific/alterlab-hypogenic/SKILL.md · 380 lines

How it starts

The opening of the file, as written. The whole thing — 380 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Hypogenic

Overview

Hypogenic provides automated hypothesis generation and testing using large language models to accelerate scientific discovery. The framework supports three approaches: HypoGeniC (data-driven hypothesis generation), HypoRefine (synergistic literature and data integration), and Union methods (mechanistic combination of literature and data-driven hypotheses).

Quick Start

Get started with Hypogenic in minutes:

# Install the package
uv pip install hypogenic

# Clone example datasets
git clone https://github.com/ChicagoHAI/HypoGeniC-datasets.git ./data

# Run basic hypothesis generation
hypogenic_generation --config ./data/your_task/config.yaml --method hypogenic --num_hypotheses 20

# Run inference on generated hypotheses
hypogenic_inference --config ./data/your_task/config.yaml --hypotheses output/hypotheses.json

Flag names below are illustrative. The upstream docs expose exact arguments only via hypogenic_generation --help / hypogenic_inference --help — confirm there before scripting.

Or use the example scripts (the library ships runnable scripts under examples/; there is no one-line fluent task.generate_hypotheses(...) API — see "Python API Usage" below for the real classes):

python ./examples/generation.py   --help   # HypoGeniC data-driven generation
python ./examples/inference.py     --help   # single-hypothesis inference

When to Use This Skill

Use this skill when working on:

  • Generating scientific hypotheses from observational datasets
  • Testing multiple competing hypotheses systematically
  • Combining literature insights with empirical patterns
  • Accelerating research discovery through automated hypothesis ideation
  • Domains requiring hypothesis-driven analysis: deception detection, AI-generated content identification, mental health indicators, predictive modeling, or other empirical research

Key Features

Automated Hypothesis Generation

  • Generate 10-20+ testable hypotheses from data in minutes
  • Iterative refinement based on validation performance
  • Support for both API-based (OpenAI, Anthropic) and local LLMs

Read the full file on GitHub · 380 lines

Files

What ships with it

7 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 5d ago First seen · 380 lines · 90 tokens per session scan A e8d714c4f79c

Subscribe to this mod's changes

alterlab-hypogenic is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (66 stars, last pushed 6d ago), licensed MIT. It adds 90 tokens to every session and 3,177 once invoked, about $0.0005 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-05.

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