alterlab-interpro

alterlab-interpro is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 131 tokens per session (3,808 once invoked), scanned A, original, MIT.

A protein-analysis lookup tool for InterPro, an EMBL-EBI database that groups proteins into families and identifies domains, repeats, and functional sites.

In plain words
What is it for?
Use it to investigate or compare protein function, family membership, domain structure, functional sites, and related sequence annotations.
Why use it?
It brings annotations from several protein databases into one queryable source, reducing the need to compare those sources manually.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Part of the alterlab-databases plugin — 39 skills shipped together

Good fit Use it to investigate or compare protein function, family membership, domain structure, functional sites, and related sequence annotations.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-interpro
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-interpro
Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills

Made for: Claude Code.

Or install alterlab-databases, the plugin that ships this one along with the rest of its 39 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-interpro

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-interpro/github.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-interpro)
Your own site
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-interpro"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-interpro/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for alterlab-interpro

Your own site · 80×15
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-interpro"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-interpro.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 131 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,808 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 1 finding. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00131 $0.03808
Opus 5 $0.00066 $0.01904
Sonnet 5 $0.00026 $0.00762
Haiku 4.5 $0.00013 $0.00381

Measured 4d ago against content hash 5948ccbc599d, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-08, from the pricing page.

Security

Grade A, and why

alterlab-interpro scanned grade A with 1 finding against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 4d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (scripts/query_interpro.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Makes network callslowCapability

Not a fault in itself. Listed so you know the mod talks to something, and to what.

allowed-tools: Read WebFetch Bash(curl:*) Bash(python:*)
skills/databases/alterlab-interpro/SKILL.md · 357 lines

How it starts

The opening of the file, as written. The whole thing — 357 lines — stays where its author put it; the contents beside it link to each section on GitHub.

InterPro Database

Overview

InterPro (https://www.ebi.ac.uk/interpro/) is a comprehensive resource for protein family and domain classification maintained by EMBL-EBI. It integrates predictive signatures from its member databases — including Pfam, PANTHER, PRINTS, ProSite, SMART, NCBIfam, SUPERFAMILY, CDD, Gene3D, and others (see the member-database table below) — into a unified set of entries, providing a single view of functional annotation across UniProtKB. (The legacy TIGRFAMs were absorbed into NCBIfam.)

InterPro classifies proteins into:

  • Families: Groups of proteins sharing common ancestry and function
  • Domains: Independently folding structural/functional units
  • Homologous superfamilies: Structurally similar protein regions
  • Repeats: Short tandem sequences
  • Sites: Functional sites (active, binding, PTM)

Key resources:

Scripts

scripts/query_interpro.py — query the InterPro REST API (stdlib only, JSON to stdout):

python scripts/query_interpro.py protein P04637          # InterPro entries for a UniProt protein
python scripts/query_interpro.py entry IPR000719         # entry details
python scripts/query_interpro.py entry-proteins IPR000719 --page-size 25   # proteins with an entry

When to Use This Skill

Use InterPro when:

  • Protein function prediction: What function(s) does an uncharacterized protein likely have?
  • Domain architecture: What domains make up a protein, and in what order?
  • Protein family classification: Which family/superfamily does a protein belong to?
  • GO term annotation: Map protein sequences to Gene Ontology terms via InterPro
  • Evolutionary analysis: Are two proteins in the same homologous superfamily?
  • Structure prediction context: What domains should a new protein structure be compared against?
  • Pipeline annotation: Batch-annotate proteomes or novel sequences

Read the full file on GitHub · 357 lines

Files

What ships with it

3 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 4d ago First seen · 357 lines · 131 tokens per session scan A 5948ccbc599d

Subscribe to this mod's changes

alterlab-interpro is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (66 stars, last pushed 4d ago), licensed MIT. It adds 131 tokens to every session and 3,808 once invoked, about $0.0007 per session on Opus 5. A static security scan graded it A with 1 finding (makes network calls). No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-05.

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