alterlab-opentargets

alterlab-opentargets is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 73 tokens per session (3,429 once invoked), scanned A, a copy of opentargets-database, MIT.

A query tool for the Open Targets Platform, a database that combines genetics, biological research, literature, and drug information to assess links between genes and diseases.

In plain words
What is it for?
Use it to find gene–disease associations, assess target safety and druggability, and identify known drugs and their clinical information.
Why use it?
It helps drug researchers gather evidence about possible treatment targets without combining these sources manually.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Part of the alterlab-databases plugin — 39 skills shipped together

Good fit Use it to find gene–disease associations, assess target safety and druggability, and identify known drugs and their clinical information.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-opentargets
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-opentargets
Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills

Made for: Claude Code.

Or install alterlab-databases, the plugin that ships this one along with the rest of its 39 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-opentargets

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-opentargets/github.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-opentargets)
Your own site
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-opentargets"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-opentargets/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for alterlab-opentargets

Your own site · 80×15
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-opentargets"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-opentargets.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 73 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,429 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 1 finding. A grade says what 26 rules found in the file — not that it is safe.
Origin 88% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00073 $0.03429
Opus 5 $0.00036 $0.01715
Sonnet 5 $0.00015 $0.00686
Haiku 4.5 $0.00007 $0.00343

Measured 6d ago against content hash d083e724a623, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-11, from the pricing page.

Security

Grade A, and why

alterlab-opentargets scanned grade A with 1 finding against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (scripts/query_opentargets.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Makes network callslowCapability

Not a fault in itself. Listed so you know the mod talks to something, and to what.

allowed-tools: Read WebFetch Bash(curl:*) Bash(python:*)
Origin

This is a copy

88% identical to opentargets-database — 89 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

skills/databases/alterlab-opentargets/SKILL.md · 382 lines

How it starts

The opening of the file, as written. The whole thing — 382 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Open Targets Database

Overview

The Open Targets Platform is a comprehensive resource for systematic identification and prioritization of potential therapeutic drug targets. It integrates publicly available datasets including human genetics, omics, literature, and chemical data to build and score target-disease associations.

Key capabilities:

  • Query target (gene) annotations including tractability, safety, expression
  • Search for disease-target associations with evidence scores
  • Retrieve evidence from multiple data types (genetics, pathways, literature, etc.)
  • Find known drugs for diseases and their mechanisms
  • Access drug information including clinical trial phases and adverse events
  • Evaluate target druggability and therapeutic potential

Data access: The platform provides a GraphQL API, web interface, data downloads, and Google BigQuery access. This skill focuses on the GraphQL API for programmatic access.

When to Use This Skill

This skill should be used when:

  • Target discovery: Finding potential therapeutic targets for a disease
  • Target assessment: Evaluating tractability, safety, and druggability of genes
  • Evidence gathering: Retrieving supporting evidence for target-disease associations
  • Drug repurposing: Identifying existing drugs that could be repurposed for new indications
  • Competitive intelligence: Understanding clinical precedence and drug development landscape
  • Target prioritization: Ranking targets based on genetic evidence and other data types
  • Mechanism research: Investigating biological pathways and gene functions
  • Biomarker discovery: Finding genes differentially expressed in disease
  • Safety assessment: Identifying potential toxicity concerns for drug targets

Core Workflow

1. Search for Entities

Start by finding the identifiers for targets, diseases, or drugs of interest.

For targets (genes):

from scripts.query_opentargets import search_entities

# Search by gene symbol or name
results = search_entities("BRCA1", entity_types=["target"])
# Returns: [{"id": "ENSG00000012048", "name": "BRCA1", ...}]

Read the full file on GitHub · 382 lines

Files

What ships with it

5 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 6d ago First seen · 382 lines · 73 tokens per session scan A d083e724a623

Subscribe to this mod's changes

alterlab-opentargets is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (66 stars, last pushed 7d ago), licensed MIT. It adds 73 tokens to every session and 3,429 once invoked, about $0.0004 per session on Opus 5. A static security scan graded it A with 1 finding (makes network calls). It is 88% identical to opentargets-database, differing in 89 lines, and is treated as a copy.

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