alterlab-pathml

alterlab-pathml is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 147 tokens per session (1,743 once invoked), scanned A, original, MIT.

A Python toolkit for analyzing digital pathology images, including whole-slide images, which are very large scans of tissue samples. It supports image preparation, cell detection, spatial graphs, and machine-learning workflows for pathology data.

In plain words
What is it for?
Use it to load and preprocess slides, find and classify cell nuclei, measure multiplexed markers, create cell or tissue graphs, and manage tiled pathology datasets.
Why use it?
It provides common steps for turning enormous tissue scans and multiplexed images into data that models and analyses can use. This avoids building separate image-processing pipelines for each slide format.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter. Also seen: mentions Codex.

Part of the alterlab-bioinformatics plugin — 38 skills shipped together

Good fit Use it to load and preprocess slides, find and classify cell nuclei, measure multiplexed markers, create cell or tissue graphs, and manage tiled pathology datasets.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-pathml
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-pathml
Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills

Made for: Claude Code.

Or install alterlab-bioinformatics, the plugin that ships this one along with the rest of its 38 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-pathml

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-pathml/github.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-pathml)
Your own site
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-pathml"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-pathml/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for alterlab-pathml

Your own site · 80×15
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-pathml"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-pathml.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 147 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,743 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00147 $0.01743
Opus 5 $0.00073 $0.00872
Sonnet 5 $0.00029 $0.00349
Haiku 4.5 $0.00015 $0.00174

Measured 9d ago against content hash e19b13bdb555, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-09, from the pricing page.

Security

Grade A, and why

alterlab-pathml scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/bioinformatics/alterlab-pathml/SKILL.md · 154 lines

How it starts

The opening of the file, as written. The whole thing — 154 lines — stays where its author put it; the contents beside it link to each section on GitHub.

PathML

Overview

PathML is a comprehensive Python toolkit for computational pathology workflows, designed to facilitate machine learning and image analysis for whole-slide pathology images. The framework provides modular, composable tools for loading diverse slide formats, preprocessing images, constructing spatial graphs, training deep learning models, and analyzing multiparametric imaging data from technologies like CODEX and multiplex immunofluorescence.

When to Use This Skill

Apply this skill for:

  • Loading and processing whole-slide images (WSI) in various proprietary formats
  • Preprocessing H&E stained tissue images with stain normalization
  • Nucleus detection, segmentation, and classification workflows
  • Building cell and tissue graphs for spatial analysis
  • Training or deploying machine learning models (HoVer-Net, HACTNet) on pathology data
  • Analyzing multiparametric imaging (CODEX, Vectra, MERFISH) for spatial proteomics
  • Quantifying marker expression from multiplex immunofluorescence
  • Managing large-scale pathology datasets with HDF5 storage
  • Tile-based analysis and stitching operations

Core Capabilities

PathML provides six major capability areas documented in detail within reference files:

1. Image Loading & Formats

Load whole-slide images from 160+ proprietary formats including Aperio SVS, Hamamatsu NDPI, Leica SCN, Zeiss ZVI, DICOM, and OME-TIFF. PathML automatically handles vendor-specific formats and provides unified interfaces for accessing image pyramids, metadata, and regions of interest.

See: references/image_loading.md for supported formats, loading strategies, and working with different slide types.

2. Preprocessing Pipelines

Build modular preprocessing pipelines by composing transforms for image manipulation, quality control, stain normalization, tissue detection, and mask operations. PathML's Pipeline architecture enables reproducible, scalable preprocessing across large datasets.

Key transforms:

  • StainNormalizationHE - Macenko/Vahadane stain normalization
  • TissueDetectionHE, NucleusDetectionHE - Tissue/nucleus segmentation
  • MedianBlur, GaussianBlur - Noise reduction
  • LabelArtifactTileHE - Quality control for artifacts

Read the full file on GitHub · 154 lines

Files

What ships with it

7 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 154 lines · 147 tokens per session scan A e19b13bdb555

Subscribe to this mod's changes

alterlab-pathml is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (66 stars, last pushed 5d ago), licensed MIT. It adds 147 tokens to every session and 1,743 once invoked, about $0.0007 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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