alterlab-reactome

alterlab-reactome is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 72 tokens per session (2,283 once invoked), scanned B, a copy of reactome-database, MIT.

A research skill for querying Reactome, a free database of curated biological pathways, through its web service or Python tools. Pathways describe how genes, proteins, and other molecules work together.

In plain words
What is it for?
It is for pathway enrichment, gene-to-pathway mapping, expression analysis, disease-pathway research, and molecular interaction queries.
Why use it?
It lets an agent examine biological relationships and enrichment results without manually searching the database.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Part of the alterlab-databases plugin — 39 skills shipped together

Good fit It is for pathway enrichment, gene-to-pathway mapping, expression analysis, disease-pathway research, and molecular interaction queries.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-reactome
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-reactome
Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills

Made for: Claude Code.

Or install alterlab-databases, the plugin that ships this one along with the rest of its 39 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-reactome

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-reactome.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-reactome)
Your own site
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-reactome"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-reactome.svg" alt="Measured on agentmods" height="20"></a>
Per session 72 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,283 The whole file, excluding the scripts and references it only reads on demand.
Security scan B 2 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin 86% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00072 $0.02283
Opus 5 $0.00036 $0.01141
Sonnet 5 $0.00014 $0.00457
Haiku 4.5 $0.00007 $0.00228

Measured 3d ago against content hash 2ff0f710960b, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-08, from the pricing page.

Security

Grade B, and why

alterlab-reactome scanned grade B with 2 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 3d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (scripts/reactome_query.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Sends data to an external URLmediumData exfiltration

A POST to an outside endpoint may be telemetry or may be exfiltration; either way the mod talks to somewhere, and you should know where.

response = requests.post( "https://reactome.org/AnalysisService/identifiers/",

Makes network callslowCapability

Not a fault in itself. Listed so you know the mod talks to something, and to what.

allowed-tools: Read WebFetch Bash(curl:*) Bash(python:*)
Origin

This is a copy

86% identical to reactome-database — 71 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

skills/databases/alterlab-reactome/SKILL.md · 319 lines

How it starts

The opening of the file, as written. The whole thing — 319 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Reactome Database

Overview

Reactome is a free, open-source, curated pathway database (thousands of human pathways). Query biological pathways, perform overrepresentation and expression analysis, map genes to pathways, explore molecular interactions via REST API and Python client for systems biology research.

When to Use This Skill

This skill should be used when:

  • Performing pathway enrichment analysis on gene or protein lists
  • Analyzing gene expression data to identify relevant biological pathways
  • Querying specific pathway information, reactions, or molecular interactions
  • Mapping genes or proteins to biological pathways and processes
  • Exploring disease-related pathways and mechanisms
  • Visualizing analysis results in the Reactome Pathway Browser
  • Conducting comparative pathway analysis across species

Core Capabilities

Reactome provides two main API services and a Python client library:

1. Content Service - Data Retrieval

Query and retrieve biological pathway data, molecular interactions, and entity information.

Common operations:

  • Retrieve pathway information and hierarchies
  • Query specific entities (proteins, reactions, complexes)
  • Get participating molecules in pathways
  • Access database version and metadata
  • Explore pathway compartments and locations

API Base URL: https://reactome.org/ContentService

2. Analysis Service - Pathway Analysis

Perform computational analysis on gene lists and expression data.

Analysis types:

  • Overrepresentation Analysis: Identify statistically significant pathways from gene/protein lists
  • Expression Data Analysis: Analyze gene expression datasets to find relevant pathways
  • Species Comparison: Compare pathway data across different organisms

API Base URL: https://reactome.org/AnalysisService

3. reactome2py Python Package

Python client library that wraps Reactome API calls for easier programmatic access.

Installation:

uv pip install reactome2py

Read the full file on GitHub · 319 lines

Files

What ships with it

3 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 3d ago First seen · 319 lines · 72 tokens per session scan B 2ff0f710960b

Subscribe to this mod's changes

alterlab-reactome is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (66 stars, last pushed 3d ago), licensed MIT. It adds 72 tokens to every session and 2,283 once invoked, about $0.0004 per session on Opus 5. A static security scan graded it B with 2 findings (sends data to an external url, makes network calls). It is 86% identical to reactome-database, differing in 71 lines, and is treated as a copy.

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