alterlab-scikit-bio

alterlab-scikit-bio is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 90 tokens per session (4,905 once invoked), scanned A, a copy of scikit-bio, MIT.

A Python library for studying DNA, RNA, proteins, and microbial communities. It also works with biological file formats, evolutionary trees, and statistical methods for comparing groups of samples.

In plain words
What is it for?
Use it to read and edit sequences, align them, analyze phylogenetic trees, measure microbial diversity, compare communities, create ordination plots, and run ecological statistical tests.
Why use it?
It provides common bioinformatics operations in one place, reducing the need to build separate code for sequence handling, evolutionary analysis, and microbiome statistics.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Part of the alterlab-bioinformatics plugin — 38 skills shipped together

Good fit Use it to read and edit sequences, align them, analyze phylogenetic trees, measure microbial diversity, compare communities, create ordination plots, and run ecological statistical tests.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-scikit-bio
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-scikit-bio
Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills

Made for: Claude Code.

Or install alterlab-bioinformatics, the plugin that ships this one along with the rest of its 38 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-scikit-bio

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-scikit-bio/github.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-scikit-bio)
Your own site
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-scikit-bio"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-scikit-bio/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for alterlab-scikit-bio

Your own site · 80×15
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-scikit-bio"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-scikit-bio.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 90 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 4,905 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin 73% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00090 $0.04905
Opus 5.5 $0.00036 $0.01962
Sonnet 5.5 $0.00018 $0.00981
Haiku 4.5 $0.00009 $0.00490

Measured 1mo ago against content hash ffbbe14935f4, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

alterlab-scikit-bio scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 1mo ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

This is a copy

73% identical to scikit-bio — 300 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

skills/bioinformatics/alterlab-scikit-bio/SKILL.md · 476 lines

How it starts

The opening of the file, as written. The whole thing — 476 lines — stays where its author put it; the contents beside it link to each section on GitHub.

scikit-bio

Overview

scikit-bio is a comprehensive Python library for working with biological data. Apply this skill for bioinformatics analyses spanning sequence manipulation, alignment, phylogenetics, microbial ecology, and multivariate statistics.

When to Use This Skill

This skill should be used when the user:

  • Works with biological sequences (DNA, RNA, protein)
  • Needs to read/write biological file formats (FASTA, FASTQ, GenBank, Newick, BIOM, etc.)
  • Performs sequence alignments or searches for motifs
  • Constructs or analyzes phylogenetic trees
  • Calculates diversity metrics (alpha/beta diversity, UniFrac distances)
  • Performs ordination analysis (PCoA, CCA, RDA)
  • Runs statistical tests on biological/ecological data (PERMANOVA, ANOSIM, Mantel)
  • Analyzes microbiome or community ecology data
  • Works with protein embeddings from language models
  • Needs to manipulate biological data tables

Does NOT Trigger

Scenario Use Instead
Running the full amplicon pipeline (demux -> DADA2 -> taxonomy -> diversity) as QIIME 2 artifacts alterlab-qiime2-amplicon
Inferring a phylogeny with a substitution model (IQ-TREE/RAxML, bootstrap support) alterlab-phylogenetics
General sequence record parsing, BLAST parsing, Entrez retrieval alterlab-biopython
Single-cell or bulk expression analysis rather than community ecology alterlab-scanpy / alterlab-pydeseq2
Generic multivariate statistics on non-compositional data alterlab-statistical-analysis

Core Capabilities

1. Sequence Manipulation

Work with biological sequences using specialized classes for DNA, RNA, and protein data.

Key operations:

  • Read/write sequences from FASTA, FASTQ, GenBank, EMBL formats
  • Sequence slicing, concatenation, and searching
  • Reverse complement, transcription (DNA→RNA), and translation (RNA→protein)
  • Find motifs and patterns using regex
  • Calculate distances (Hamming, k-mer based)
  • Handle sequence quality scores and metadata

Read the full file on GitHub · 476 lines

Files

What ships with it

2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 1mo ago Changed · +35 lines ffbbe14935f4
  2. 1mo ago First seen · 441 lines · 90 tokens per session scan A bdca2af78cca

Subscribe to this mod's changes

alterlab-scikit-bio is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (78 stars, last pushed yesterday), licensed MIT. It adds 90 tokens to every session and 4,905 once invoked, about $0.0004 per session on Opus 5.5. A static security scan graded it A with 0 findings. It is 73% identical to scikit-bio, differing in 300 lines, and is treated as a copy.

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