alterlab-squidpy-spatial

alterlab-squidpy-spatial is a skill for Claude Code from AlterLab-IEU/AlterLab-Academic-Skills. It costs 201 tokens per session (2,392 once invoked), scanned A, original, MIT.

A toolkit for analyzing where cells and gene activity are located inside tissue. Spatial transcriptomics measures gene activity while preserving each measurement's position, so the results can be linked to neighboring cells and tissue structure.

In plain words
What is it for?
Use it to find neighboring and co-occurring cell types, identify genes that vary by location, study possible cell-to-cell signals, and read data from platforms such as Visium, Xenium, MERFISH, and CosMx.
Why use it?
Standard single-cell analysis can show which cell types are present but not which cells are next to each other or where genes vary across a tissue sample.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter.

Part of the alterlab-bioinformatics plugin — 38 skills shipped together

Good fit Use it to find neighboring and co-occurring cell types, identify genes that vary by location, study possible cell-to-cell signals, and read data from platforms such as Visium, Xenium, MERFISH, and CosMx.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/alterlab-ieu/alterlab-academic-skills/alterlab-squidpy-spatial
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-squidpy-spatial
Clone the repo
git clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills

Made for: Claude Code.

Or install alterlab-bioinformatics, the plugin that ships this one along with the rest of its 38 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for alterlab-squidpy-spatial

README.md
[![agentmods](https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-squidpy-spatial/github.svg)](https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-squidpy-spatial)
Your own site
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-squidpy-spatial"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-squidpy-spatial/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for alterlab-squidpy-spatial

Your own site · 80×15
<a href="https://agentmods.dev/skills/alterlab-ieu/alterlab-academic-skills/alterlab-squidpy-spatial"><img src="https://agentmods.dev/badge/skills/alterlab-ieu/alterlab-academic-skills/alterlab-squidpy-spatial.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 201 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,392 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00201 $0.02392
Opus 5 $0.00101 $0.01196
Sonnet 5 $0.00040 $0.00478
Haiku 4.5 $0.00020 $0.00239

Measured 10d ago against content hash 65aac736120d, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-09, from the pricing page.

Security

Grade A, and why

alterlab-squidpy-spatial scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 10d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (scripts/spatial_neighborhood.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/bioinformatics/alterlab-squidpy-spatial/SKILL.md · 168 lines

How it starts

The opening of the file, as written. The whole thing — 168 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Squidpy: Spatial Transcriptomics

Squidpy is the scverse toolkit for spatially-resolved omics, built on AnnData and SpatialData. It answers questions a non-spatial scRNA-seq pipeline cannot: which cell types sit next to which (neighborhood enrichment), how cell-type pairs co-occur across distance (co-occurrence), which genes vary across tissue space (Moran's I / spatially variable genes), and what ligand-receptor signalling is plausible (ligrec). This skill does the spatial analysis; it hands non-spatial QC/clustering to alterlab-scanpy and spot deconvolution to alterlab-scvi-tools.

When to Use This Skill

Use when the request involves:

  • Spatial transcriptomics / spatially-resolved omics on Visium, Visium HD, Xenium, MERFISH/MERSCOPE, or CosMx data.
  • Building a spatial neighbor graph and running neighborhood enrichment, co-occurrence, interaction matrix, Ripley's statistics, or centrality scores.
  • Finding spatially variable genes via Moran's I (spatial_autocorr) or Sepal.
  • Ligand-receptor analysis in a spatial context (ligrec).
  • Reading platform output into AnnData/SpatialData and choosing the right coord_type for the platform.

Does NOT Trigger

Request Route to
Non-spatial scRNA-seq QC, normalization, PCA/UMAP, Leiden clustering, marker genes alterlab-scanpy
Spot deconvolution / mapping cell types to Visium spots (destVI, Tangram), probabilistic batch correction/integration alterlab-scvi-tools (see its references/models-spatial.md)
Building/slicing/concatenating .h5ad AnnData objects, layer & obsm wrangling (no spatial analysis) alterlab-anndata
RNA-velocity / trajectory dynamics alterlab-scvelo
Bulk RNA-seq differential expression from a count matrix alterlab-pydeseq2
Raw FASTQ → expression matrix (read alignment/quantification) alterlab-rnaseq-quant
Diversity / ecology statistics on a feature table alterlab-scikit-bio

Read the full file on GitHub · 168 lines

Files

What ships with it

5 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 10d ago First seen · 168 lines · 201 tokens per session scan A 65aac736120d

Subscribe to this mod's changes

alterlab-squidpy-spatial is a skill published in the GitHub repository AlterLab-IEU/AlterLab-Academic-Skills (66 stars, last pushed 5d ago), licensed MIT. It adds 201 tokens to every session and 2,392 once invoked, about $0.0010 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

Other skills, from other repositories

r-spss-syntax-architect

A guide for turning research hypotheses into repeatable R or SPSS code for statistical analysis. It covers panel data, where the same companies or other units are observed over time, as well as interaction effects, curves, and mediation.

Nero1688/claude-academic-skills · 406 tokens

ob-hrm-scale-adaptor

A guide for adapting organisational behaviour and human-resources survey scales across languages and cultures. It covers permission checks, translation and back-translation, expert review, participant interviews, and tests of whether groups interpret the scale comparably.

Nero1688/claude-academic-skills · 318 tokens

management-figure

A chart-making toolkit for evidence-based management, finance, and strategy research. It creates publication-ready plots from regression results and tracking data, including coefficient, interaction, group-comparison, trend, and curved-relationship charts.

Nero1688/claude-academic-skills · 374 tokens

reproducibility-architect

A guide for packaging research so another person can rerun its data processing and analysis. A replication package is the project files, instructions, code, data guidance, and software details needed to reproduce published results.

Nero1688/claude-academic-skills · 606 tokens

thesis-consistency-audit

A consistency audit for quantitative master’s and doctoral theses in management, finance, or strategy. It checks whether numbers, tables, analyses, and claims agree, and can inspect hidden author information in office documents.

Nero1688/claude-academic-skills · 500 tokens

journal-submission-scout

A research tool for choosing a journal for a completed paper. It searches for journals that publish similar work, compares public information such as citation data, fees, open-access listing, and review practices, and screens for warning signs of predatory journals, which charge authors without providing trustworthy publishing services.

Nero1688/claude-academic-skills · 479 tokens