clinvar-annotation

clinvar-annotation is a skill for Claude Code, Codex from ammawla/encode-toolkit. It costs 77 tokens per session (4,866 once invoked), scanned A, original, AGPL-3.0.

A guide for checking whether genome regions or variants studied in ENCODE have clinical interpretations in ClinVar, a database of links between genetic variants and human health conditions.

In plain words
What is it for?
It helps find pathogenic variants in regulatory regions, review ClinVar clinical significance, and assess the possible clinical impact of variants found in ENCODE peaks.
Why use it?
It helps determine whether regulatory DNA changes have known clinical associations or reported disease relevance.

Skill for Claude CodeCodex

Part of the encode-toolkit plugin — 37 skills shipped together

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/ammawla/encode-toolkit/clinvar-annotation
Any agent
npx skills add ammawla/encode-toolkit --skill clinvar-annotation
Clone the repo
git clone --depth 1 https://github.com/ammawla/encode-toolkit

Made for: Claude Code, Codex.

Or install encode-toolkit, the plugin that ships this one along with the rest of its 37 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for clinvar-annotation

README.md
[![agentmods](https://agentmods.dev/badge/skills/ammawla/encode-toolkit/clinvar-annotation.svg)](https://agentmods.dev/skills/ammawla/encode-toolkit/clinvar-annotation)
Your own site
<a href="https://agentmods.dev/skills/ammawla/encode-toolkit/clinvar-annotation"><img src="https://agentmods.dev/badge/skills/ammawla/encode-toolkit/clinvar-annotation.svg" alt="Measured on agentmods" height="20"></a>
Per session 77 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 4,866 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 1 finding. Scan, not verified.
Origin unknown No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5 $0.00077 $0.04866
Opus 5 $0.00039 $0.02433
Sonnet 5 $0.00015 $0.00973
Haiku 4.5 $0.00008 $0.00487

Measured 4d ago against content hash fb7b9f64392f, method: parsed. Prices are Anthropic first-party input rates as of 2026-08-30, from the pricing page.

Security

Grade A, and why

clinvar-annotation scanned grade A with 1 finding against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 4d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Makes network callslowCapability

Not a fault in itself. Listed so you know the mod talks to something, and to what.

response = requests.get(url, params=params)
plugin/skills/clinvar-annotation/SKILL.md · 445 lines

The source is not reproduced here

Licensed AGPL-3.0

The repository is licensed AGPL-3.0, which this catalogue does not treat as permission to reproduce the file. Read it at the source.

Read it on GitHub

Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 4d ago First seen · 445 lines · 77 tokens per session scan A fb7b9f64392f

Subscribe to this mod's changes

clinvar-annotation is a skill published in the GitHub repository ammawla/encode-toolkit (24 stars, last pushed 1mo ago), licensed AGPL-3.0. It adds 77 tokens to every session and 4,866 once invoked, about $0.0004 per session on Opus 5. A static security scan graded it A with 1 finding (makes network calls). No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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