meta-analysis

meta-analysis is a skill for Claude Code from Aperivue/medsci-skills. It costs 77 tokens per session (9,100 once invoked), scanned A, original, MIT.

A workflow for systematic reviews, which collect and assess all relevant studies on a medical question, and meta-analysis, which combines their results statistically. It covers planning, study screening, bias checks, analysis, and PRISMA reporting.

In plain words
What is it for?
Use it to prepare a PROSPERO protocol, search and screen studies, extract data, assess study quality, combine results, and prepare a manuscript.
Why use it?
It keeps a review organised and makes its methods easier to check and report. It also supports different methods for diagnostic tests and medical treatments.

Skill for Claude Code

Written for Claude Code: ${CLAUDE_SKILL_DIR} variable.

Part of the medsci-analysis plugin — 6 skills shipped together

Good fit Use it to prepare a PROSPERO protocol, search and screen studies, extract data, assess study quality, combine results, and prepare a manuscript.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/aperivue/medsci-skills/meta-analysis
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add Aperivue/medsci-skills --skill meta-analysis
Clone the repo
git clone --depth 1 https://github.com/Aperivue/medsci-skills

Made for: Claude Code.

Or install medsci-analysis, the plugin that ships this one along with the rest of its 6 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for meta-analysis

README.md
[![agentmods](https://agentmods.dev/badge/skills/aperivue/medsci-skills/meta-analysis/github.svg)](https://agentmods.dev/skills/aperivue/medsci-skills/meta-analysis)
Your own site
<a href="https://agentmods.dev/skills/aperivue/medsci-skills/meta-analysis"><img src="https://agentmods.dev/badge/skills/aperivue/medsci-skills/meta-analysis/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for meta-analysis

Your own site · 80×15
<a href="https://agentmods.dev/skills/aperivue/medsci-skills/meta-analysis"><img src="https://agentmods.dev/badge/skills/aperivue/medsci-skills/meta-analysis.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 77 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 9,100 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00077 $0.09100
Opus 5.5 $0.00031 $0.03640
Sonnet 5.5 $0.00015 $0.01820
Haiku 4.5 $0.00008 $0.00910

Measured 9d ago against content hash d93ba5e58010, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

meta-analysis scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

The scan reads SKILL.md. This mod also ships 18 executable files (references/ai_pre_screening_template.py, scripts/check_exclusion_code_validity_challenge/verify.sh, scripts/check_exclusion_code_validity.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/meta-analysis/SKILL.md · 560 lines

How it starts

The opening of the file, as written. The whole thing — 560 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Meta-Analysis Skill

Meta-Analysis Types

Type RoB Tool Statistical Model Reporting Guideline
DTA (diagnostic test accuracy) QUADAS-3 (QUADAS-2 for legacy reviews) Bivariate / HSROC PRISMA-DTA
Intervention (treatment effect) RoB 2 (RCT) / ROBINS-I (NRSI) Random-effects (REML, Hartung-Knapp CI) PRISMA 2020
Prognostic factor (association of one factor with outcome) QUIPS Random-effects PRISMA 2020
Prediction model (model performance) PROBAST Random-effects PRISMA 2020
Observational (prevalence/association) NOS / JBI Random-effects MOOSE

If the type is ambiguous (DTA vs intervention), ask the user to clarify before proceeding.


Workflow Phases

Phase 1: Protocol Development

Goal: Produce a PROSPERO-ready protocol document. Write the protocol, extraction forms and manuscript text in English whatever language the user writes in — PROSPERO records and the target journals are English-language.

  1. Research question: PIRD (Population, Index test, Reference standard, Diagnosis) for DTA; PICO (Population, Intervention, Comparator, Outcome) for intervention.

  2. DTA only — do QUADAS-3 phases 1 and 2 now, not at risk-of-bias time. They are review-level and belong in the protocol: phase 1 states the synthesis question(s) (population, index test(s), target condition — a review may have more than one); phase 2 defines the ideal test accuracy trial for each (objective, participants, index test(s), definition of the target condition, analysis). Every later risk-of-bias and applicability judgement is made against that trial. Write the review-specific guidance for answering each signalling question here too, with clinical and methodological input, and publish it as a web appendix. Defining the ideal trial after seeing the studies is a judgement fitted to the results, not an assessment. See references/checklists/QUADAS3.md.

Read the full file on GitHub · 560 lines

Files

What ships with it

59 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago Changed · +18 lines d93ba5e58010
  2. 20d ago Changed · +8 lines ddf417f4a9d4
  3. 21d ago Changed · +1 lines e3f137979a13
  4. 22d ago Changed 062e7dd70188
  5. 24d ago Changed · -166 lines · -3 tokens per session 94d29ab38b7c
  6. 25d ago Changed 9d2d6aa9fa32
  7. 1mo ago First seen · 699 lines · 80 tokens per session scan A ad348da8d8ea

Subscribe to this mod's changes

meta-analysis is a skill published in the GitHub repository Aperivue/medsci-skills (349 stars, last pushed 2d ago), licensed MIT. It adds 77 tokens to every session and 9,100 once invoked, about $0.0003 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

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