ligandmpnn

ligandmpnn is a skill for Claude Code, Codex from BioTender-max/awesome-bio-agent-skills. It costs 86 tokens per session (1,376 once invoked), scanned A, original, no licence file.

A protein sequence design method that accounts for nearby small molecules, metals, or other chemical components while designing the surrounding protein.

In plain words
What is it for?
Use it to design enzyme active sites, optimize ligand-binding pockets, create metal-coordination sites, or design proteins around cofactors.
Why use it?
A sequence designed without considering these components may not form the intended binding pocket or active site. This method includes them in the design context.

Skill for Claude CodeCodex

Which agent this was written for is unclear — body not stored (licence); the path alone says nothing.

Good fit Use it to design enzyme active sites, optimize ligand-binding pockets, create metal-coordination sites, or design proteins around cofactors.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/biotender-max/awesome-bio-agent-skills/ligandmpnn
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add BioTender-max/awesome-bio-agent-skills --skill ligandmpnn
Clone the repo
git clone --depth 1 https://github.com/BioTender-max/awesome-bio-agent-skills

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for ligandmpnn

README.md
[![agentmods](https://agentmods.dev/badge/skills/biotender-max/awesome-bio-agent-skills/ligandmpnn/github.svg)](https://agentmods.dev/skills/biotender-max/awesome-bio-agent-skills/ligandmpnn)
Your own site
<a href="https://agentmods.dev/skills/biotender-max/awesome-bio-agent-skills/ligandmpnn"><img src="https://agentmods.dev/badge/skills/biotender-max/awesome-bio-agent-skills/ligandmpnn/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for ligandmpnn

Your own site · 80×15
<a href="https://agentmods.dev/skills/biotender-max/awesome-bio-agent-skills/ligandmpnn"><img src="https://agentmods.dev/badge/skills/biotender-max/awesome-bio-agent-skills/ligandmpnn.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 86 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,376 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin unknown No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00086 $0.01376
Opus 5 $0.00043 $0.00688
Sonnet 5 $0.00017 $0.00275
Haiku 4.5 $0.00009 $0.00138

Measured 12d ago against content hash 37b9dcd94189, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-11, from the pricing page.

Security

Grade A, and why

ligandmpnn scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 12d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/adaptyv/ligandmpnn/SKILL.md · 171 lines

The source is not reproduced here

A licence we could not identify

The repository carries a LICENSE file, but it is custom or dual enough that GitHub cannot name it and neither can this catalogue. Unknown terms are not permission, so the body is not copied here. Read the licence at the source and decide for yourself.

Read it on GitHub

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 12d ago First seen · 171 lines · 86 tokens per session scan A 37b9dcd94189

Subscribe to this mod's changes

ligandmpnn is a skill published in the GitHub repository BioTender-max/awesome-bio-agent-skills (176 stars, last pushed 2mo ago), with no licence file. It adds 86 tokens to every session and 1,376 once invoked, about $0.0004 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

Other skills, from other repositories

ligandmpnn

Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For…

zongtingwei/Bioclaw_Skills_Hub · 86 tokens

ligandmpnn

Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For…

adaptyvbio/protein-design-skills · 86 tokens

proteinmpnn

Design protein sequences using ProteinMPNN inverse folding. Use this skill when: (1) Designing sequences for RFdiffusion backbones, (2) Redesigning existing protein sequences, (3) Fixing specific residues while designing others, (4) Optimizing sequences for expression or stability, (5) Multi-state or negative design.…

zongtingwei/Bioclaw_Skills_Hub · 106 tokens

solublempnn

Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubility of designed proteins, (3) Reducing aggregation propensity, (4) Need high-yield expression, (5) Avoiding inclusion body formation. For standard design, use proteinmpnn.…

zongtingwei/Bioclaw_Skills_Hub · 91 tokens

bindcraft

End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high…

FridrichMethod/awesome-skills · 104 tokens

ligandmpnn

Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For…

BioTender-max/ProteinClaw · 86 tokens