proteinmpnn

proteinmpnn is a skill for Claude Code, Codex from BioTender-max/awesome-bio-agent-skills. It costs 106 tokens per session (2,176 once invoked), scanned A, original, no licence file.

A protein-sequence design tool based on ProteinMPNN, which chooses amino-acid sequences that fit a given protein structure.

In plain words
What is it for?
Use it to design sequences for RFdiffusion backbones, redesign proteins, fix specific residues, optimize expression or stability, and perform multi-state or negative design.
Why use it?
It helps turn designed or existing protein structures into candidate sequences, while allowing selected residues to stay fixed. It can also target properties such as expression or stability.

Skill for Claude CodeCodex

Which agent this was written for is unclear — body not stored (licence); the path alone says nothing.

Good fit Use it to design sequences for RFdiffusion backbones, redesign proteins, fix specific residues, optimize expression or stability, and perform multi-state or negative design.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/biotender-max/awesome-bio-agent-skills/proteinmpnn
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add BioTender-max/awesome-bio-agent-skills --skill proteinmpnn
Clone the repo
git clone --depth 1 https://github.com/BioTender-max/awesome-bio-agent-skills

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for proteinmpnn

README.md
[![agentmods](https://agentmods.dev/badge/skills/biotender-max/awesome-bio-agent-skills/proteinmpnn/github.svg)](https://agentmods.dev/skills/biotender-max/awesome-bio-agent-skills/proteinmpnn)
Your own site
<a href="https://agentmods.dev/skills/biotender-max/awesome-bio-agent-skills/proteinmpnn"><img src="https://agentmods.dev/badge/skills/biotender-max/awesome-bio-agent-skills/proteinmpnn/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for proteinmpnn

Your own site · 80×15
<a href="https://agentmods.dev/skills/biotender-max/awesome-bio-agent-skills/proteinmpnn"><img src="https://agentmods.dev/badge/skills/biotender-max/awesome-bio-agent-skills/proteinmpnn.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 106 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,176 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin unknown No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00106 $0.02176
Opus 5 $0.00053 $0.01088
Sonnet 5 $0.00021 $0.00435
Haiku 4.5 $0.00011 $0.00218

Measured 13d ago against content hash 7f2a86aa6792, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

proteinmpnn scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 13d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/adaptyv/proteinmpnn/SKILL.md · 280 lines

The source is not reproduced here

A licence we could not identify

The repository carries a LICENSE file, but it is custom or dual enough that GitHub cannot name it and neither can this catalogue. Unknown terms are not permission, so the body is not copied here. Read the licence at the source and decide for yourself.

Read it on GitHub

Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 13d ago First seen · 280 lines · 106 tokens per session scan A 7f2a86aa6792

Subscribe to this mod's changes

proteinmpnn is a skill published in the GitHub repository BioTender-max/awesome-bio-agent-skills (178 stars, last pushed 2mo ago), with no licence file. It adds 106 tokens to every session and 2,176 once invoked, about $0.0005 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

Other skills, from other repositories

proteinmpnn

Design protein sequences using ProteinMPNN inverse folding. Use this skill when: (1) Designing sequences for RFdiffusion backbones, (2) Redesigning existing protein sequences, (3) Fixing specific residues while designing others, (4) Optimizing sequences for expression or stability, (5) Multi-state or negative design.…

zongtingwei/Bioclaw_Skills_Hub · 106 tokens

ligandmpnn

Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For…

zongtingwei/Bioclaw_Skills_Hub · 86 tokens

solublempnn

Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubility of designed proteins, (3) Reducing aggregation propensity, (4) Need high-yield expression, (5) Avoiding inclusion body formation. For standard design, use proteinmpnn.…

zongtingwei/Bioclaw_Skills_Hub · 91 tokens

bindcraft

End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high…

FridrichMethod/awesome-skills · 104 tokens

proteinmpnn

Design protein sequences using ProteinMPNN inverse folding. Use this skill when: (1) Designing sequences for RFdiffusion backbones, (2) Redesigning existing protein sequences, (3) Fixing specific residues while designing others, (4) Optimizing sequences for expression or stability, (5) Multi-state or negative design.…

adaptyvbio/protein-design-skills · 106 tokens

ligandmpnn

Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For…

adaptyvbio/protein-design-skills · 86 tokens