rfdiffusion

rfdiffusion is a skill for Claude Code, Codex from BioTender-max/awesome-bio-agent-skills. It costs 119 tokens per session (2,666 once invoked), scanned A, original, no licence file.

A protein-structure generation tool based on RFdiffusion, a machine-learning model that creates new three-dimensional protein backbones.

In plain words
What is it for?
Use it to design binding-protein frameworks, generate new protein backbones, and place functional motifs into new protein structures.
Why use it?
It helps explore protein shapes that do not already exist, including structures designed around a target or a useful functional feature.

Skill for Claude CodeCodex

Which agent this was written for is unclear — body not stored (licence); the path alone says nothing.

Good fit Use it to design binding-protein frameworks, generate new protein backbones, and place functional motifs into new protein structures.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/biotender-max/awesome-bio-agent-skills/rfdiffusion
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add BioTender-max/awesome-bio-agent-skills --skill rfdiffusion
Clone the repo
git clone --depth 1 https://github.com/BioTender-max/awesome-bio-agent-skills

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for rfdiffusion

README.md
[![agentmods](https://agentmods.dev/badge/skills/biotender-max/awesome-bio-agent-skills/rfdiffusion/github.svg)](https://agentmods.dev/skills/biotender-max/awesome-bio-agent-skills/rfdiffusion)
Your own site
<a href="https://agentmods.dev/skills/biotender-max/awesome-bio-agent-skills/rfdiffusion"><img src="https://agentmods.dev/badge/skills/biotender-max/awesome-bio-agent-skills/rfdiffusion/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for rfdiffusion

Your own site · 80×15
<a href="https://agentmods.dev/skills/biotender-max/awesome-bio-agent-skills/rfdiffusion"><img src="https://agentmods.dev/badge/skills/biotender-max/awesome-bio-agent-skills/rfdiffusion.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 119 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,666 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 1 finding. A grade says what 26 rules found in the file — not that it is safe.
Origin unknown No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00119 $0.02666
Opus 5 $0.00060 $0.01333
Sonnet 5 $0.00024 $0.00533
Haiku 4.5 $0.00012 $0.00267

Measured 12d ago against content hash 8e4558e1ecc5, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

rfdiffusion scanned grade A with 1 finding against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 12d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Makes network callslowCapability

Not a fault in itself. Listed so you know the mod talks to something, and to what.

wget http://files.ipd.uw.edu/pub/RFdiffusion/models/Complex_base_ckpt.pt
skills/adaptyv/rfdiffusion/SKILL.md · 307 lines

The source is not reproduced here

A licence we could not identify

The repository carries a LICENSE file, but it is custom or dual enough that GitHub cannot name it and neither can this catalogue. Unknown terms are not permission, so the body is not copied here. Read the licence at the source and decide for yourself.

Read it on GitHub

Files

What ships with it

3 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 12d ago First seen · 307 lines · 119 tokens per session scan A 8e4558e1ecc5

Subscribe to this mod's changes

rfdiffusion is a skill published in the GitHub repository BioTender-max/awesome-bio-agent-skills (178 stars, last pushed 2mo ago), with no licence file. It adds 119 tokens to every session and 2,666 once invoked, about $0.0006 per session on Opus 5. A static security scan graded it A with 1 finding (makes network calls). No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

Other skills, from other repositories

rfdiffusion

Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1) Designing binder scaffolds for a target protein, (2) Generating novel protein backbones from scratch, (3) Scaffolding functional motifs into new proteins, (4) Specifying…

zongtingwei/Bioclaw_Skills_Hub · 130 tokens

rfdiffusion

Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1) Designing binder scaffolds for a target protein, (2) Generating novel protein backbones from scratch, (3) Scaffolding functional motifs into new proteins, (4) Specifying…

adaptyvbio/protein-design-skills · 119 tokens

boltzgen

All-atom protein design using BoltzGen diffusion model. Use this skill when: (1) Need side-chain aware design from the start, (2) Designing around small molecules or ligands, (3) Want all-atom diffusion (not just backbone), (4) Require precise binding geometries, (5) Using YAML-based configuration. For backbone-only…

zongtingwei/Bioclaw_Skills_Hub · 108 tokens

bindcraft

End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high…

FridrichMethod/awesome-skills · 104 tokens

protein-structure-design-boltzgen

All-atom protein design using BoltzGen diffusion model. Use this skill when: (1) Need side-chain aware design from the start, (2) Designing around small molecules or ligands, (3) Want all-atom diffusion (not just backbone), (4) Require precise binding geometries, (5) Using YAML-based configuration. For structure…

PharMolix/OpenBioMed · 89 tokens

boltzgen

All-atom protein design using BoltzGen diffusion model. Use this skill when: (1) Need side-chain aware design from the start, (2) Designing around small molecules or ligands, (3) Want all-atom diffusion (not just backbone), (4) Require precise binding geometries, (5) Using YAML-based configuration. For backbone-only…

adaptyvbio/protein-design-skills · 103 tokens