Claude

Claude is a skill for Claude Code, Codex from Dr-AneeshJoseph/Prism. It costs 0 tokens per session (2,679 once invoked), scanned A, original, MIT.

A structured method for investigating scientific questions and comparing explanations using evidence and probability. It is implemented as a skill for Claude, an AI assistant made by Anthropic.

In plain words
What is it for?
Evaluating scientific hypotheses, synthesizing research evidence, comparing treatments or technologies, estimating probabilities, and prioritizing research questions.
Why use it?
It gives research tasks a defined way to combine evidence, compare competing explanations, and express uncertainty instead of treating results as simply true or false.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Evaluating scientific hypotheses, synthesizing research evidence, comparing treatments or technologies, estimating probabilities, and prioritizing research questions.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/dr-aneeshjoseph/prism/claude
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add Dr-AneeshJoseph/Prism --skill claude
Clone the repo
git clone --depth 1 https://github.com/Dr-AneeshJoseph/Prism

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for Claude

README.md
[![agentmods](https://agentmods.dev/badge/skills/dr-aneeshjoseph/prism/claude/github.svg)](https://agentmods.dev/skills/dr-aneeshjoseph/prism/claude)
Your own site
<a href="https://agentmods.dev/skills/dr-aneeshjoseph/prism/claude"><img src="https://agentmods.dev/badge/skills/dr-aneeshjoseph/prism/claude/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for Claude

Your own site · 80×15
<a href="https://agentmods.dev/skills/dr-aneeshjoseph/prism/claude"><img src="https://agentmods.dev/badge/skills/dr-aneeshjoseph/prism/claude.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 0 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,679 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00000 $0.02679
Opus 5.5 $0.00000 $0.01072
Sonnet 5.5 $0.00000 $0.00536
Haiku 4.5 $0.00000 $0.00268

Measured 1mo ago against content hash 513ba7df3af2, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

Claude scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 1mo ago.

The scan reads SKILL.md. This mod also ships 1 executable file (prism_session.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Claude/SKILL.md · 386 lines

How it starts

The opening of the file, as written. The whole thing — 386 lines — stays where its author put it; the contents beside it link to each section on GitHub.

PRISM v2.2 - Protocol for Rigorous Investigation of Scientific Mechanisms

Author: Dr. Aneesh Joseph
Implementation: Claude (Anthropic)
Version: 2.2 | December 2025


When to Use This Skill

Use PRISM when the user asks to:

  • Evaluate scientific hypotheses quantitatively
  • Compare multiple hypotheses using Bayesian methods
  • Perform rigorous evidence synthesis with meta-analysis
  • Calculate posterior probabilities from heterogeneous evidence
  • Research and prioritize scientific questions
  • Assess treatment options, drug efficacy, or technology predictions

Trigger phrases:

  • "Find the best hypothesis for..."
  • "Compare these hypotheses..."
  • "What's the probability that..."
  • "Analyze the evidence for..."
  • "Which treatment is most likely to work..."

Core Philosophy

Traditional hypothesis testing asks: "Is this result statistically significant?"

PRISM asks: "Given all available evidence, what is the probability this hypothesis is true?"

This shift from binary significance to continuous credence enables:

  • Comparison across different evidence types
  • Principled evidence accumulation
  • Explicit uncertainty quantification
  • Optimizer's curse correction for multiple comparisons

Mathematical Framework

Bayesian Foundation

PRISM uses Bayes' theorem with log-odds for numerical stability:

log-odds(H|E) = log-odds(H) + log(LR)

Reference Class Priors

Instead of arbitrary priors, PRISM uses empirical base rates with Beta distributions:

  • phase2_clinical: 15.3% [9.0%, 23.0%] (based on FDA 2000-2020)
  • phase3_clinical: 35.1% [26.2%, 44.7%]
  • replication: 40.1% [30.8%, 49.8%] (based on OSF 2015)
  • general: 50.0% (uninformative)

Hierarchical Correlation Correction

Critical: Naive multiplication of likelihood ratios causes exponential overconfidence.

PRISM uses hierarchical correlation:

  • Within-cluster ρ = 0.6 (same lab/method)
  • Between-cluster ρ = 0.2 (independent labs)
Effective N = Σ(cluster_size / DEFF_within) / √DEFF_between

Read the full file on GitHub · 386 lines

Files

What ships with it

3 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 1mo ago First seen · 386 lines · 0 tokens per session scan A 513ba7df3af2

Subscribe to this mod's changes

Claude is a skill published in the GitHub repository Dr-AneeshJoseph/Prism (7 stars, last pushed 10mo ago), licensed MIT. It costs nothing until one of its globs matches a file; then it loads 2,679 tokens. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-31.

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