drug-targets

Drug Targets

Use this skill for disease-scoped clinical drug-target retrieval, direct drug-target records, PharmaProjects-style target context, ChEMBL mechanism genes, DrugBank target context, or candidate-gene review for a drug, drug class, or mechanism.

Contract

• Direct drug-target or mechanism evidence outranks target-disease association scores and GWAS-style association.
• ChEMBL, DrugBank, and PharmaProjects-style records can support direct target claims when the source supports both the gene and the drug, class, mechanism, or indication context.
• Open Targets association context is useful for review; direct drug-target evidence comes from source records that support the drug, class, or mechanism relationship.
• Open Targets disease drug and clinical candidate records can retrieve disease-scoped clinical drug-target genes when the drug target comes from a mechanism-of-action row.
• Treat returned rankings as source evidence. The agent decides whether the drug-target prior matches the question. When using cross-source comparison, use prior_fit before reading a panel as task-relevant and audit decision_evidence before answering.

Tool Flow

1. phenotype.retrieve_disease_drug_targets retrieves Open Targets clinical drug candidate target genes for a supplied disease anchor.
2. phenotype.compare_drug_target_evidence compares candidate genes against direct drug-side context: drug, drug class, or mechanism.
3. If source support is missing, use research.list_sources to choose direct target sources, review them, and store narrow findings with research.record.
4. Re-run the same selected tool after recording reviewed findings.

Example:

• phenotype.retrieve_disease_drug_targets with {"disease":"asthma","genes":["ADRB2","IL13"]}
• phenotype.compare_drug_target_evidence with {"drug_class":"beta agonist","phenotype":"asthma","genes":["ADRB2","IL13"],"source_records":[{"genes":["ADRB2"],"drug_class":"beta agonist","verified_fields":{"genes":["ADRB2"],"drug_class":"beta agonist"},"support_spans":[{"field":"genes","text":"source-backed ADRB2 text"}]}]}