exon-research

exon-research/genomi

Instructions file CodexOpenCode

Instructions for exon-research/genomi, covering genomi development agent instructions, genomi design principles, connect, operating rule and fresh task flow.

exon-research/genomi

Instructions file

Instructions for exon-research/genomi, a project described as: Local-first, open-source Claude Science alternative, before Claude Science is a thing. Turn your AI agent into personal DNA expert.

exon-research/genomi

Skill Claude CodeCodex

Use this skill for genetics, genome source, variant, gene, phenotype, disease, screen, pharmacogenomics, and Genomi install/setup maintenance questions.

exon-research/genomi

Skill Claude CodeCodex

Register, parse, and digitize private genome source files into a local Active Genome Index and supporting evidence stores. Use when the session explicitly supplies a VCF/gVCF, BAM, genome.computer .genome/1.0 bundle, 23andMe raw genotype export, AncestryDNA raw genotype export, MyHeritage raw genotype export…

exon-research/genomi

Skill Claude CodeCodex

Retrieve canonical pathway members, cell-type marker records, and genomic interval feature overlaps from declared analytical sources.

exon-research/genomi

Skill Claude CodeCodex

Use local ancestry reference-panel tools for 1000 Genomes GRCh37/GRCh38 PCA projection, marker overlap QC, and qualitative reference-neighbor context.

exon-research/genomi

Skill Claude CodeCodex

Build and inspect ClinVar exact-match evidence and candidate inventories. Use for clinical labels, VUS/conflict, carrier context, and drug-response rows.

exon-research/genomi

Skill Claude CodeCodex

Activate this skill for "/genomi decode", "decode my genome", "decode my DNA", "show me the dashboard", "the Genomi dashboard", "one-shot rundown", or any all-at-once request that asks Genomi to compose every capability's findings into a single artifact. This is the whole-genome dashboard kicker — it sweeps every…

exon-research/genomi

Skill Claude CodeCodex

Causal drug-target and mechanism gene prioritization from public source records, drugs, drug classes, mechanisms, and candidate gene lists.

exon-research/genomi

Skill Claude CodeCodex

Candidate gene evidence from perturbation, dependency, resistance, sensitivity, viability, or assay-context records.

exon-research/genomi

Skill Claude CodeCodex

Default entry for natural-language DNA questions. The host agent resolves intent, reads focused skills, calls narrow evidence tools, and adapts after inspecting tool output.

exon-research/genomi

Skill Claude CodeCodex

Run or continue patient-authorized, genome-informed GenomiLab investigations in the current Claude, Codex, or other MCP agent task. Use when a patient asks to open the Research Desk, investigate a condition against their active genome, review an existing investigation, supply follow-up information, revise a…

exon-research/genomi

Skill Claude CodeCodex

Fetch reusable public population allele frequencies from gnomAD for a specific variant. Use when the user asks about allele frequency, MAF, population stratification, gnomAD numbers, or rarity of a specific allele.

exon-research/genomi

Skill Claude CodeCodex

Compare candidate rsIDs against GWAS Catalog phenotype associations. Use association evidence with source and ancestry limitations.

exon-research/genomi

Skill Claude CodeCodex

Maintain agent-authored investigation memory over Genomi evidence links, reviewed source findings, decisions, contradictions, and unresolved questions.

exon-research/genomi

Skill Claude CodeCodex

Curated single-marker evidence for declared nutrient-metabolism, food-tolerance, and taste-perception domains. Refuses diet prescriptions, supplement dosing, weight-loss prediction, methylation-cycle prescriptions, microbiome-mediated effects, and other out-of-scope nutrigenomic claims.

exon-research/genomi

Skill Claude CodeCodex

Answer drug-response, medication, PharmGKB-style, PGxDB, ATC, DrugBank, gene-drug, and variant-drug questions using public PGx evidence plus local sample genotype support when an Active Genome Index is selected.

exon-research/genomi

Skill Claude CodeCodex

Apply published polygenic scores from PGS Catalog to approved local personal DNA and return raw weighted score plus overlap QC.

exon-research/genomi

Skill Claude CodeCodex

Plan rare disease, hereditary disease, cancer risk, carrier-relevance, and observed-condition source investigation from public targets or selected active genome evidence.

exon-research/genomi

Skill Claude CodeCodex

Deterministic sequence utilities for translation, ORFs, restriction sites, Kozak context, primer checks, and local FASTA record matching.

exon-research/genomi

Skill Claude CodeCodex

Journal sub-skill for focused public/source evidence review and reviewed finding write-back before interpretation or answer synthesis.

exon-research/genomi

Skill Claude CodeCodex

Answer specific rsID, allele, gene, region, genotype, and absence/callability questions using explicit session context or public evidence.