Getting it into your agent
One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.
npx skills add exon-research/genomi --skill variant-evidencegit clone --depth 1 https://github.com/exon-research/genomiWrote this? Show the measurements
A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.
[](https://agentmods.dev/skills/exon-research/genomi/variant-evidence)<a href="https://agentmods.dev/skills/exon-research/genomi/variant-evidence"><img src="https://agentmods.dev/badge/skills/exon-research/genomi/variant-evidence/github.svg" alt="Measured on agentmods" height="20"></a>Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.
<a href="https://agentmods.dev/skills/exon-research/genomi/variant-evidence"><img src="https://agentmods.dev/badge/skills/exon-research/genomi/variant-evidence.svg" alt="Reviewed on agentmods" width="80" height="20"></a>- NVIDIA SkillSpector pass
What it costs to keep this loaded
Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.
| Model | Per session | Once invoked |
|---|---|---|
| Fable 5.1 | $0.00032 | $0.01853 |
| Opus 5 | $0.00016 | $0.00927 |
| Sonnet 5 | $0.00006 | $0.00371 |
| Haiku 4.5 | $0.00003 | $0.00185 |
Grade A, and why
variant-evidence scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 10d ago.
A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.
Nothing flagged
None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.
How it starts
The opening of the file, as written. The whole thing — 188 lines — stays where its author put it; the contents beside it link to each section on GitHub.
Variant And Gene Evidence
Use this skill when the user asks about a specific rsID, allele, gene, genomic region, observed genotype, absence/reference claim, or whether the user's own Active Genome Index supports a claim.
Goal
Answer with the smallest evidence packet needed. Use sample support and callability checks when the claim requires them.
Run genomi.describe_context first if the Active Genome Index is unknown. If an active
Active Genome Index exists, use it for sample-specific lookup. With public-only
context, answer from public/source evidence or ask the user for a file only
when personal evidence is required.
Use variant.resolve as the umbrella first lookup when the user's target is an
rsID, coordinate, exact allele, locus, region, or mixed text. It resolves
flexible input, checks the Active Genome Index, gathers existing deterministic
ClinVar/population/reviewed-source facts, and can search explicitly selected
accessible Active Genome Index records with agi_id or include_known_active_genome_indexes.
Convention: See
skills/conventions/evidence-quality.md. Convention: Seeskills/_output-rules.md.
Contract
Contract:
- Personal variant claims are grounded in the selected Active Genome Index.
- Public-only variant answers are clearly marked public-only.
- Absence/reference claims require callability.
- Positive allele claims use genotype support when answer confidence matters.
- Medical meaning beyond static rows uses Journal source-review memory.
Cross-Capability Synthesis
A scope-limited result from this capability is not a final user-facing answer when other Genomi capabilities can contribute orthogonal evidence to the same question. Returning "cannot answer" while applicable capabilities remain unexamined is a host-agent failure mode.
Tools
active_genome_index.classify_genotype_support
Classify whether one exact allele has enough sample support to be used in a personal interpretation.
Use when: A user-specific interpretation depends on whether one exact allele is actually supported by Active Genome Index genotype/QC evidence.
What this file has done since we first saw it
Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.
- 10d ago First seen · 188 lines · 32 tokens per session scan A f741b9a6d665
variant-evidence is a skill published in the GitHub repository exon-research/genomi (482 stars, last pushed 9d ago), licensed Apache-2.0. It adds 32 tokens to every session and 1,853 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.
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