FridrichMethod/awesome-skills

Curated, auto-synced collection of 2,000+ Claude Code & Codex skills for AI4Protein, bioinformatics, AI development, and academic paper writing. One curl command installs them all.

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FridrichMethod/awesome-skills

Skill Claude CodeCodex

Retrieve and analyze AlphaFold predicted structures for a protein. Use when the user provides a specific UniProt Accession ID and wants structural confidence metrics (pLDDT), domain boundary analysis, or disorder assessment. Do not use if the user only has a protein name, gene name, or amino acid sequence — ask for a…

not rated 15 3d ago A 80 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene…

not rated 15 3d ago A 118 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Infers exact amplicon sequence variants (ASVs) from demultiplexed 16S rRNA or ITS amplicon FASTQ with DADA2 - removing primers with cutadapt (--discard-untrimmed), learning a per-run error model (filterAndTrim -> learnErrors -> dada -> mergePairs), merging run-level tables with mergeSequenceTables, then one…

not rated 15 3d ago A 261 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Profiles the antimicrobial-resistance gene content (resistome) of shotgun metagenomes - read-based quantification with RGI bwt, AMR++/MEGARes, ARGs-OAP/SARG, deepARG, or GROOT, and presence calling with AMRFinderPlus/ABRicate on assembled contigs or MAGs. Covers why an ARG hit is a sequence match not a phenotype, why…

not rated 15 3d ago A 192 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Detects acquired antimicrobial-resistance determinants and chromosomal point-mutation resistance in bacterial assemblies using AMRFinderPlus, ResFinder 4.0 (acquired + PointFinder), CARD-RGI, abritAMR, staramr, and species-specific callers (TB-Profiler, Mykrobe). Harmonises cross-tool output via hAMRonization…

not rated 15 3d ago A 234 tokens

FridrichMethod/awesome-skills

Skill Claude Code

Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP / / , ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays…

not rated 15 changed 2d ago A 281 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Treats a ctDNA assay as a molecule-counting experiment at the Poisson edge and builds its analytical-validation case the measurement-science way. Covers the genome-equivalent currency (330 haploid copies/ng), the lambda = inputGE x VAF sampling ceiling (lambda>=3 for 95% detection), the error-suppression ladder (raw…

not rated 15 3d ago A 228 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when…

not rated 15 3d ago A 149 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Clean Architecture patterns for Android and Kotlin Multiplatform projects — module structure, dependency rules, UseCases, Repositories, and data layer patterns.

not rated 15 3d ago A 34 tokens

angular-migration

58

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Migrate from AngularJS to Angular using hybrid mode, incremental component rewriting, and dependency injection updates. Use when upgrading AngularJS applications, planning framework migrations, or modernizing legacy Angular code.

not rated 15 3d ago A 42 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Annotated matrices for single-cell genomics. Stores X with obs/var metadata, layers, embeddings (obsm/varm), graphs (obsp/varp), uns. Use for .h5ad/.zarr I/O, concatenation, scverse integration. For analysis use scanpy; for probabilistic models use scvi-tools.

not rated 15 3d ago A 76 tokens

anndata

60

FridrichMethod/awesome-skills

Skill Claude Code

Data structure for annotated matrices in single-cell analysis. Use when working with .h5ad files or integrating with the scverse ecosystem. This is the data format skill—for analysis workflows use scanpy; for probabilistic models use scvi-tools; for population-scale queries use cellxgene-census.

not rated 15 changed 2d ago A 63 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Assesses the quality and completeness of a genome annotation with BUSCO (conserved single-copy ortholog recovery), OMArk (proteome completeness, consistency, and contamination), CheckM2 (prokaryotic completeness/contamination), and a gene-set sanity panel (gene count, mono-exonic fraction, protein-length distribution…

not rated 15 3d ago A 151 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Transfers gene annotations between genome assemblies via coordinate liftover (UCSC liftOver, CrossMap for same-species version updates) or feature/sequence projection (Liftoff for same/close species, miniprot for protein-level cross-species, TOGA/GeMoMa/CAT for distant clades). Covers the coordinate-vs-projection…

not rated 15 3d ago A 152 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Understand anti-reversing, obfuscation, and protection techniques encountered during software analysis. Use this skill when analyzing malware evasion techniques, when implementing anti-debugging protections for CTF challenges, when reverse engineering packed binaries, or when building security research tools that need…

not rated 15 3d ago A 66 tokens

FridrichMethod/awesome-skills

Skill Claude Code

Skill "mage-antibody-generator" from FridrichMethod/awesome-skills, covering copyright notice, copyright (c) 2026 md babu mia, phd, all rights reserved, this code is proprietary and confidential and provenance: authenticated by md babu mia.

not rated 15 3d ago A 8 tokens

FridrichMethod/awesome-skills

Skill Claude Code

An advanced agent for de novo antibody design and optimization using state-of-the-art protein language models (MAGE, RFdiffusion).

not rated 15 3d ago A 31 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Master REST and GraphQL API design principles to build intuitive, scalable, and maintainable APIs that delight developers. Use when designing new APIs, reviewing API specifications, or establishing API design standards.

not rated 15 3d ago A 44 tokens

api-design

67

FridrichMethod/awesome-skills

Skill Claude CodeCodex

REST API design patterns including resource naming, status codes, pagination, filtering, error responses, versioning, and rate limiting for production APIs.

not rated 15 3d ago A 31 tokens

api-hardening

68

FridrichMethod/awesome-skills

Skill Codex

API hardening for Express, FastAPI, and serverless. Use for rate limiting, CORS, input validation, API keys, or OWASP API Top 10.

not rated 15 3d ago B 39 tokens

arbor

69

FridrichMethod/awesome-skills

Skill Claude Code

Autonomously improve a real artifact (code, training recipe, agent harness, data pipeline, prompt) against an objective and an evaluator, using Hypothesis Tree Refinement (HTR) from the Arbor paper. Use this whenever someone wants to iteratively optimize something over many experiments without overfitting — e.g. "get…

not rated 15 changed 2d ago A 217 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

GRN inference from expression via GRNBoost2 (gradient boosting) or GENIE3 (Random Forest). Load matrix, filter by TFs, infer TF-target-importance links, save network. Dask-parallelized to single-cell scale. Core SCENIC component.

not rated 15 3d ago A 64 tokens

arboreto

71

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for…

not rated 15 changed 2d ago A 66 tokens

FridrichMethod/awesome-skills

Skill Claude CodeCodex

Write and maintain Architecture Decision Records (ADRs) following best practices for technical decision documentation. Use when documenting significant technical decisions, reviewing past architectural choices, or establishing decision processes.

not rated 15 3d ago A 41 tokens

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