bio-ncbi-datasets-cli

bio-ncbi-datasets-cli is a skill for Claude Code, Codex from GPTomics/bioSkills. It costs 126 tokens per session (3,683 once invoked), scanned A, original, MIT.

A guide to using NCBI Datasets, the National Center for Biotechnology Information's command-line tool, to download genome assemblies, gene records, and ortholog data. Orthologs are corresponding genes shared across species through evolution.

In plain words
What is it for?
Use it to bulk-download genome assemblies, gene metadata, ortholog sets, and BLAST databases from NCBI.
Why use it?
It replaces slower manual downloads and file scraping for genome and gene data while keeping related records together.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to bulk-download genome assemblies, gene metadata, ortholog sets, and BLAST databases from NCBI.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/gptomics/bioskills/ncbi-datasets-cli
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add GPTomics/bioSkills --skill ncbi-datasets-cli
Clone the repo
git clone --depth 1 https://github.com/GPTomics/bioSkills

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bio-ncbi-datasets-cli

README.md
[![agentmods](https://agentmods.dev/badge/skills/gptomics/bioskills/ncbi-datasets-cli/github.svg)](https://agentmods.dev/skills/gptomics/bioskills/ncbi-datasets-cli)
Your own site
<a href="https://agentmods.dev/skills/gptomics/bioskills/ncbi-datasets-cli"><img src="https://agentmods.dev/badge/skills/gptomics/bioskills/ncbi-datasets-cli/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for bio-ncbi-datasets-cli

Your own site · 80×15
<a href="https://agentmods.dev/skills/gptomics/bioskills/ncbi-datasets-cli"><img src="https://agentmods.dev/badge/skills/gptomics/bioskills/ncbi-datasets-cli.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 126 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,683 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 2 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00126 $0.03683
Opus 5 $0.00063 $0.01842
Sonnet 5 $0.00025 $0.00737
Haiku 4.5 $0.00013 $0.00368

Measured 8d ago against content hash 4871acf86594, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

bio-ncbi-datasets-cli scanned grade A with 2 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 8d ago.

The scan reads SKILL.md. This mod also ships 3 executable files (examples/bulk_dehydrated.sh, examples/download_genome.sh, examples/gene_metadata.sh), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Makes network callslowCapability

Not a fault in itself. Listed so you know the mod talks to something, and to what.

curl -O https://ftp.ncbi.nlm.nih.gov/pub/datasets/command-line/v2/linux-amd64/datasets

Runs shell commandslowCapability

Expected in a hook, worth knowing in a rule or an instructions file.

out = subprocess.run(cmd, capture_output=True, text=True, check=True)
Origin

Copies of this mod

1 near-identical copy found in the catalogue:

database-access/ncbi-datasets-cli/SKILL.md · 311 lines

How it starts

The opening of the file, as written. The whole thing — 311 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Version Compatibility

Reference examples tested with: NCBI Datasets CLI 16.0+ (2024), dataformat 16.0+

Before using code patterns, verify installed versions match. If versions differ:

  • CLI: datasets --version, dataformat --version
  • Subcommand help: datasets <subcommand> --help

If a subcommand or flag is unrecognized, run datasets --help and adapt. The CLI is under active development; major releases (v15 -> v16) added subcommands and renamed flags.

NCBI Datasets CLI

"Pull genome / gene / ortholog data from NCBI in 2026" -> The Datasets v2 CLI (launched 2023) is the official, supported bulk endpoint for genome and gene-centric data. It replaces the prior best-practice of scraping assembly_summary.txt + parallel FTP + manual checksum verification. For genome-scale data, it is strictly better than E-utilities (EFetch).

The CLI is not the right answer for everything. PubMed, SRA reads, and custom Entrez queries still belong to E-utilities. The defection rule: if the question is about genome assemblies, gene records, or pre-computed orthologs, use Datasets; otherwise stay with E-utilities.

  • CLI: datasets download genome accession GCF_...
  • CLI: datasets summary gene symbol BRCA1 --taxon human
  • Python: subprocess wrapper; Python client ncbi-datasets-pylib (experimental as of 2024)

Installation

# conda
conda install -c conda-forge ncbi-datasets-cli

# Or direct download (Linux, macOS, Windows binaries)
curl -O https://ftp.ncbi.nlm.nih.gov/pub/datasets/command-line/v2/linux-amd64/datasets

datasets --version    # 16.0+ expected
dataformat --version  # bundled companion tool

What's in scope (use Datasets) vs out of scope (use E-utilities or other tools)

Question Datasets Use instead
Genome assembly download yes
All reference genomes for a taxon yes
Gene record metadata (multi-species) yes
Ortholog data for a gene yes (datasets summary gene ... --ortholog) OrthoDB / Compara for tree-aware orthology
Virus data (assemblies, metadata) yes (datasets download virus)
Annotation files (GFF3, GTF) for a genome yes
Protein records (curated, with cross-refs) partial UniProt REST for richer annotation
PubMed no entrez-search / entrez-fetch
SRA reads no sra-data
BLAST no blast-searches / local-blast
Custom Entrez queries no entrez-search
Pre-computed alignments (Compara) no ensembl-rest

Read the full file on GitHub · 311 lines

Files

What ships with it

4 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 8d ago First seen · 311 lines · 126 tokens per session scan A 4871acf86594

Subscribe to this mod's changes

bio-ncbi-datasets-cli is a skill published in the GitHub repository GPTomics/bioSkills (1,201 stars, last pushed 27d ago), licensed MIT. It adds 126 tokens to every session and 3,683 once invoked, about $0.0006 per session on Opus 5. A static security scan graded it A with 2 findings (makes network calls, runs shell commands). No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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