principal-component-analysis-visualization

principal-component-analysis-visualization is a skill for Claude Code, Codex from HolobiomicsLab/asb-skill-collections. It costs 59 tokens per session (1,303 once invoked), scanned A, original, Apache-2.0.

A principal component analysis procedure for unified DNA methylation data. Principal component analysis summarises the largest patterns of variation, and the procedure produces plots showing sample relationships and variance explained.

In plain words
What is it for?
Analyse a unified methylation dataset, create a variance scree plot and a two-component sample plot, and inspect sample-level relationships.
Why use it?
It makes similarities, differences, and possible groupings between samples easier to inspect. It also helps show which major patterns account for most of the variation in the methylation profiles.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Analyse a unified methylation dataset, create a variance scree plot and a two-component sample plot, and inspect sample-level relationships.

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Install with agentmods
npx agentmods add skills/holobiomicslab/asb-skill-collections/principal-component-analysis-visualization
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add HolobiomicsLab/asb-skill-collections --skill principal-component-analysis-visualization
Clone the repo
git clone --depth 1 https://github.com/HolobiomicsLab/asb-skill-collections

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

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README.md
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Your own site
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Per session 59 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,303 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00059 $0.01303
Opus 5 $0.00030 $0.00651
Sonnet 5 $0.00012 $0.00261
Haiku 4.5 $0.00006 $0.00130

Measured 6d ago against content hash 5267902c4275, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

principal-component-analysis-visualization scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

collections/epigenomics/v1/skills/principal-component-analysis-visualization/SKILL.md · 96 lines

How it starts

The opening of the file, as written. The whole thing — 96 lines — stays where its author put it; the contents beside it link to each section on GitHub.

principal-component-analysis-visualization

Summary

Apply PCA to methylation profiles from a unified methylBase object to reveal sample relationships and variance structure in principal component space. Generates a scree plot showing variance explained by each PC and a biplot of the first two principal components to assess methylation-based sample grouping.

When to use

After merging methylation call files from multiple samples using unite() to create a methylBase object, apply PCA when you need to visualize sample-level relationships based on overall methylation similarity across all covered bases, or when you want to determine which principal components explain the most variance in methylation profiles among your samples.

When NOT to use

  • Input is a raw methylRawList (unmunged per-sample files) — must first run unite() to create methylBase.
  • You need to perform clustering by correlation distance with Ward linkage — use clusterSamples() instead, which produces a dendrogram.
  • Sample count is very small (n < 3) — PCA is unstable with fewer samples than dimensions.

Inputs

  • methylBase object (unified methylation data from unite() across all samples and bases)
  • sample metadata (optional, for labeling and coloring scatter plot points)

Outputs

  • scree plot (variance explained by each principal component)
  • PC1 vs PC2 scatter plot (sample coordinates in first two principal components)
  • principal component scores matrix (numeric coordinates for all samples and PCs)

How to apply

Load the methylBase object produced by unite() from merged methylation calls. Apply the PCASamples() function from methylKit to compute principal components of the methylation profile matrix. Extract the scree plot showing variance explained by each PC to determine the number of informative components. Then visualize the first two principal components (PC1 and PC2) as a scatter plot with samples as points, colored or labeled by experimental group (e.g., test1, test2, ctrl1, ctrl2). The function performs centering and scaling on the methylation data before eigenvalue decomposition. Interpret clustering patterns in PC space: samples that cluster together have similar methylation profiles, while separation along PC1 and PC2 indicates major sources of methylation variation between experimental groups.

Read the full file on GitHub · 96 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 6d ago First seen · 96 lines · 59 tokens per session scan A 5267902c4275

Subscribe to this mod's changes

principal-component-analysis-visualization is a skill published in the GitHub repository HolobiomicsLab/asb-skill-collections (15 stars, last pushed 2d ago), licensed Apache-2.0. It adds 59 tokens to every session and 1,303 once invoked, about $0.0003 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-06.

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