open-targets

open-targets is a skill for Claude Code from K-Dense-AI/drug-discovery-agent-skills. It costs 124 tokens per session (2,466 once invoked), scanned A, original, MIT.

A connection to the Open Targets Platform, a database that links genes and diseases using genetic, clinical, pathway, and other evidence.

In plain words
What is it for?
Use it to find gene–disease links, assess evidence and safety, compare targets, and check known drugs and how they work.
Why use it?
It helps answer whether a gene is worth studying for a disease and what is already known about it, without combining those sources manually.

Skill for Claude Code

Written for Claude Code: allowed-tools in frontmatter. Also seen: built for openclaw.

Good fit Use it to find gene–disease links, assess evidence and safety, compare targets, and check known drugs and how they work.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/k-dense-ai/drug-discovery-agent-skills/open-targets
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add K-Dense-AI/drug-discovery-agent-skills --skill open-targets
Clone the repo
git clone --depth 1 https://github.com/K-Dense-AI/drug-discovery-agent-skills

Made for: Claude Code.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for open-targets

README.md
[![agentmods](https://agentmods.dev/badge/skills/k-dense-ai/drug-discovery-agent-skills/open-targets/github.svg)](https://agentmods.dev/skills/k-dense-ai/drug-discovery-agent-skills/open-targets)
Your own site
<a href="https://agentmods.dev/skills/k-dense-ai/drug-discovery-agent-skills/open-targets"><img src="https://agentmods.dev/badge/skills/k-dense-ai/drug-discovery-agent-skills/open-targets/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for open-targets

Your own site · 80×15
<a href="https://agentmods.dev/skills/k-dense-ai/drug-discovery-agent-skills/open-targets"><img src="https://agentmods.dev/badge/skills/k-dense-ai/drug-discovery-agent-skills/open-targets.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 124 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,466 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 2 findings, up to medium

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • medium Data Exfiltration · line 24
    Data is being sent to an external URL. This could be legitimate telemetry or data exfiltration. Manual review is recommended.
    Fix: Verify the destination URL is trusted and necessary. Remove or replace with documented APIs. Ensure no secrets, tokens, or PII are transmitted.
  • medium Data Exfiltration · line 26
    Data is being sent to an external URL. This could be legitimate telemetry or data exfiltration. Manual review is recommended.
    Fix: Verify the destination URL is trusted and necessary. Remove or replace with documented APIs. Ensure no secrets, tokens, or PII are transmitted.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00124 $0.02466
Opus 5 $0.00062 $0.01233
Sonnet 5 $0.00025 $0.00493
Haiku 4.5 $0.00012 $0.00247

Measured 12d ago against content hash 12d0da2b3bc6, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

open-targets scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 12d ago.

The scan reads SKILL.md. This mod also ships 3 executable files (scripts/_common.py, scripts/ot_associations.py, scripts/ot_query.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/open-targets/SKILL.md · 196 lines

How it starts

The opening of the file, as written. The whole thing — 196 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Open Targets Platform

Open Targets aggregates genetic, somatic, clinical, pathway, expression, animal-model, and literature evidence into scored target–disease associations, and attaches druggability and safety annotation to every target. It answers the question that comes before any modelling work: is this target worth working on for this disease, and what is already known about it?

Endpoint: https://api.platform.opentargets.org/api/v4/graphql — POST, JSON, no key. Docs: platform-docs.opentargets.org · playground Checked against: the live API, August 2026 — meta reports API 26.6.3, data release 26.06.

Read references/graphql-schema.md before writing a query by hand, references/datasources.md before interpreting or filtering a score, and references/query-cookbook.md for tested documents to adapt.

Start here: three identifier rules

Everything else fails downstream of getting these wrong.

  1. Targets are Ensembl gene ids (ENSG00000146648) — never symbols, UniProt accessions, or transcript ids.
  2. Diseases are MONDO ids (MONDO_0005233) in almost all cases, even though the argument is still named efoId. Most EFO_* ids from older tutorials now return null silently. A few nodes legitimately keep EFO_, HP_, or OTAR_ ids, so you cannot rewrite the prefix — resolve the name and use what comes back.
  3. Drugs are ChEMBL molecule ids (CHEMBL939).

Always resolve first:

python skills/open-targets/scripts/ot_query.py resolve EGFR "non-small cell lung carcinoma" gefitinib
term                             id                name                           entity  score
EGFR                             ENSG00000146648   EGFR                           target  1
non-small cell lung carcinoma    MONDO_0005233     non-small cell lung carcinoma  disease 1
gefitinib                        CHEMBL2087361     ICOTINIB                       drug    1
gefitinib                        CHEMBL553         ERLOTINIB                      drug    1
gefitinib                        CHEMBL939         GEFITINIB                      drug    1

Read the full file on GitHub · 196 lines

Files

What ships with it

6 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 12d ago First seen · 196 lines · 124 tokens per session scan A 12d0da2b3bc6

Subscribe to this mod's changes

open-targets is a skill published in the GitHub repository K-Dense-AI/drug-discovery-agent-skills (28 stars, last pushed 5d ago), licensed MIT. It adds 124 tokens to every session and 2,466 once invoked, about $0.0006 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.