ToolUniverse is a collection of tools, interfaces, and supporting components for building AI systems that perform scientific work. It is for developers creating AI scientist agents that use APIs, databases, machine-learning tools, and domain-specific utilities. The catalogue includes skills, commands, an MCP server, an agent, and a hook for working with the ecosystem.
Getting it into your agent
One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.
npx skills add mims-harvard/ToolUniverse --skill tooluniverse-adverse-outcome-pathwaygit clone --depth 1 https://github.com/mims-harvard/ToolUniverseWrote this? Show the measurements
A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.
[](https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-adverse-outcome-pathway)<a href="https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-adverse-outcome-pathway"><img src="https://agentmods.dev/badge/skills/mims-harvard/tooluniverse/tooluniverse-adverse-outcome-pathway/github.svg" alt="Measured on agentmods" height="20"></a>Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.
<a href="https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-adverse-outcome-pathway"><img src="https://agentmods.dev/badge/skills/mims-harvard/tooluniverse/tooluniverse-adverse-outcome-pathway.svg" alt="Reviewed on agentmods" width="80" height="20"></a>- NVIDIA SkillSpector pass
What it costs to keep this loaded
Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.
| Model | Per session | Once invoked |
|---|---|---|
| Fable 5.1 | $0.00094 | $0.02480 |
| Opus 5 | $0.00047 | $0.01240 |
| Sonnet 5 | $0.00019 | $0.00496 |
| Haiku 4.5 | $0.00009 | $0.00248 |
Grade A, and why
tooluniverse-adverse-outcome-pathway scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 12d ago.
A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.
Nothing flagged
None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.
How it starts
The opening of the file, as written. The whole thing — 168 lines — stays where its author put it; the contents beside it link to each section on GitHub.
Adverse Outcome Pathway & Regulatory Risk Assessment
Distinct from drug safety (see tooluniverse-toxicology): this skill targets environmental and industrial chemicals where the focus is AOP stressor mapping, GHS classification, LD50 hazard quantification, and IARC carcinogen status — not FAERS signals or FDA drug labels.
When to Use
Apply when researcher asks about:
- "What AOPs are associated with [pesticide/solvent/industrial chemical]?"
- "What is the GHS hazard classification for [compound]?"
- "What is the LD50 for [compound]?"
- "Is [compound] a carcinogen (IARC classification)?"
- "Which genes does [chemical] interact with (CTD)?"
- "Regulatory risk assessment for [environmental chemical]"
- "What diseases are associated with [chemical] exposure?"
Do NOT use for FDA-approved drugs with FAERS data — use tooluniverse-toxicology instead.
Key Tools
| Tool | Purpose | Key Params |
|---|---|---|
AOPWiki_list_aops |
Discover AOPs by keyword | keyword (organ, effect, or target name) |
AOPWiki_get_aop |
Full AOP details: MIE, key events, stressors | aop_id (int) |
PubChemTox_get_toxicity_summary |
Narrative toxicity overview | cid (PubChem CID) |
PubChemTox_get_ghs_classification |
GHS hazard category + pictograms | cid |
PubChemTox_get_carcinogen_classification |
IARC/NTP/EPA carcinogen status | cid |
PubChemTox_get_toxicity_values |
LD50/LC50 by route and species | cid |
PubChemTox_get_acute_effects |
Signs and symptoms of acute exposure | cid |
CTD_get_chemical_gene_interactions |
Chemical-gene molecular interactions | input_terms (name or MeSH ID) |
CTD_get_chemical_diseases |
Chemical-disease associations | input_terms |
PubChem_get_CID_by_compound_name |
Resolve compound name to PubChem CID | name |
Workflow
Phase 1: Compound Identity Resolution
Resolve chemical name to PubChem CID before all PubChemTox calls.
PubChem_get_CID_by_compound_name(name="benzo[a]pyrene")
-> cid: 9153 (use for all PubChemTox calls)
What this file has done since we first saw it
Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.
- 12d ago First seen · 168 lines · 94 tokens per session scan A 494b3bc03289
tooluniverse-adverse-outcome-pathway is a skill published in the GitHub repository mims-harvard/ToolUniverse (1,680 stars, last pushed 2d ago), licensed Apache-2.0. It adds 94 tokens to every session and 2,480 once invoked, about $0.0005 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.
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