ToolUniverse is a collection of tools, interfaces, and supporting components for building AI systems that perform scientific work. It is for developers creating AI scientist agents that use APIs, databases, machine-learning tools, and domain-specific utilities. The catalogue includes skills, commands, an MCP server, an agent, and a hook for working with the ecosystem.
Getting it into your agent
One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.
npx skills add mims-harvard/ToolUniverse --skill tooluniverse-drug-synergygit clone --depth 1 https://github.com/mims-harvard/ToolUniverseWrote this? Show the measurements
A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.
[](https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-drug-synergy)<a href="https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-drug-synergy"><img src="https://agentmods.dev/badge/skills/mims-harvard/tooluniverse/tooluniverse-drug-synergy/github.svg" alt="Measured on agentmods" height="20"></a>Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.
<a href="https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-drug-synergy"><img src="https://agentmods.dev/badge/skills/mims-harvard/tooluniverse/tooluniverse-drug-synergy.svg" alt="Reviewed on agentmods" width="80" height="20"></a>- NVIDIA SkillSpector pass
What it costs to keep this loaded
Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.
| Model | Per session | Once invoked |
|---|---|---|
| Fable 5.1 | $0.00135 | $0.01513 |
| Opus 5 | $0.00068 | $0.00757 |
| Sonnet 5 | $0.00027 | $0.00303 |
| Haiku 4.5 | $0.00014 | $0.00151 |
Grade A, and why
tooluniverse-drug-synergy scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 13d ago.
A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.
Nothing flagged
None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.
How it starts
The opening of the file, as written. The whole thing — 80 lines — stays where its author put it; the contents beside it link to each section on GitHub.
Drug-Combination Synergy Analysis
Decide whether a two-drug combination does more than expected (synergy), exactly as expected (additivity), or less (antagonism) — and pick the right reference model for the data you have.
"Synergy" only means something relative to a null model of additivity, and the models define additivity differently — so the first decision is which model, driven by what data you measured.
Step 0 — Pick the model by the data you have
| You measured… | Use model | Tool | Input |
|---|---|---|---|
| Single effects of A, B, and A+B at one dose pair | Bliss | DrugSynergy_calculate_bliss |
effect_a, effect_b, effect_combination (each a fraction 0–1) |
| Effects of A, B, A+B across several dose points | HSA | DrugSynergy_calculate_hsa |
effects_a, effects_b, effects_combo (arrays) |
| Single-agent dose-response curves + one combination point | Loewe | DrugSynergy_calculate_loewe |
doses_a_single/effects_a_single, doses_b_single/effects_b_single, dose_a_combo, dose_b_combo, effect_combo |
| Single-agent dose-response + combo point, want Chou-Talalay CI | Combination Index | DrugSynergy_calculate_ci |
same as Loewe + assumption |
| A full dose × dose viability matrix | ZIP | DrugSynergy_calculate_zip |
doses_a, doses_b, viability_matrix (% , 0–100) |
Effects must be on a consistent inhibition scale. Bliss/HSA/Loewe expect fractional inhibition
0–1(0 = no effect, 1 = complete kill). If your data is % viability, convert:inhibition = 1 − viability/100. ZIP takes the viability matrix in % directly. Mixing scales is the most common error.
Step 1 — What each model's "additivity" means
| Model | Null (additive) expectation | Best when |
|---|---|---|
| Bliss independence | drugs act independently: E_exp = E_a + E_b − E_a·E_b |
different mechanisms; quick single-point screen |
| HSA (highest single agent) | combo should beat the better single agent: E_exp = max(E_a, E_b) |
conservative "does it beat monotherapy?" question |
| Loewe additivity | a drug combined with itself = additive (dose equivalence) | same/similar mechanism; needs dose-response |
| ZIP | combines Bliss + Loewe; potency shift of one drug's curve by the other | dose-matrix screens (the SynergyFinder default) |
| Chou-Talalay CI | CI<1 synergy, =1 additive, >1 antagonism (median-effect) | classic isobologram-style analysis with dose-response |
What ships with it
1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.
What this file has done since we first saw it
Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.
- 13d ago First seen · 80 lines · 135 tokens per session scan A cc2b347b0f1a
tooluniverse-drug-synergy is a skill published in the GitHub repository mims-harvard/ToolUniverse (1,680 stars, last pushed 3d ago), licensed Apache-2.0. It adds 135 tokens to every session and 1,513 once invoked, about $0.0007 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.
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