ToolUniverse is a collection of tools, interfaces, and supporting components for building AI systems that perform scientific work. It is for developers creating AI scientist agents that use APIs, databases, machine-learning tools, and domain-specific utilities. The catalogue includes skills, commands, an MCP server, an agent, and a hook for working with the ecosystem.
Getting it into your agent
One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.
npx skills add mims-harvard/ToolUniverse --skill tooluniverse-polygenic-risk-scoregit clone --depth 1 https://github.com/mims-harvard/ToolUniverseWrote this? Show the measurements
A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.
[](https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-polygenic-risk-score)<a href="https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-polygenic-risk-score"><img src="https://agentmods.dev/badge/skills/mims-harvard/tooluniverse/tooluniverse-polygenic-risk-score/github.svg" alt="Measured on agentmods" height="20"></a>Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.
<a href="https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-polygenic-risk-score"><img src="https://agentmods.dev/badge/skills/mims-harvard/tooluniverse/tooluniverse-polygenic-risk-score.svg" alt="Reviewed on agentmods" width="80" height="20"></a>- NVIDIA SkillSpector pass
What it costs to keep this loaded
Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.
| Model | Per session | Once invoked |
|---|---|---|
| Fable 5.1 | $0.00072 | $0.03953 |
| Opus 5.5 | $0.00029 | $0.01581 |
| Sonnet 5.5 | $0.00014 | $0.00791 |
| Haiku 4.5 | $0.00007 | $0.00395 |
Grade A, and why
tooluniverse-polygenic-risk-score scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 10d ago.
A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.
Nothing flagged
None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.
How it starts
The opening of the file, as written. The whole thing — 309 lines — stays where its author put it; the contents beside it link to each section on GitHub.
Polygenic Risk Score (PRS) Builder
Build and interpret polygenic risk scores for complex diseases using genome-wide association study (GWAS) data.
Reasoning Strategy
A polygenic risk score predicts genetic risk, not disease. A high PRS means elevated risk relative to the population — it does not mean the person will develop the condition, and a low PRS does not confer immunity. PRS performance varies dramatically across ancestries: a European-derived PRS applied to a West African population can lose 50–70% of its predictive power because the underlying GWAS was trained on European allele frequencies and LD patterns. Effect sizes from discovery GWAS are subject to winner's curse (overestimation in single studies); always prefer weights from large meta-analyses or validated PGS Catalog models. PRS should always be interpreted in the context of non-genetic risk factors — for most complex diseases, environmental factors contribute as much or more than genetics.
LOOK UP DON'T GUESS: Do not assume effect sizes, allele frequencies, or which SNPs are genome-wide significant for a trait — always query GWAS Catalog (gwas_get_associations_for_trait) for actual data. Do not assume a validated PRS model exists for a trait; check PGS Catalog via PubMed search.
Overview
Use Cases:
- "Calculate my genetic risk for type 2 diabetes"
- "Build a polygenic risk score for coronary artery disease"
- "What's my genetic predisposition to Alzheimer's disease?"
- "Interpret my PRS percentile for breast cancer risk"
What This Skill Does:
- Extracts genome-wide significant variants (p < 5e-8) from GWAS Catalog
- Builds weighted PRS models using effect sizes (beta coefficients)
- Calculates individual risk scores from genotype data
- Interprets PRS as population percentiles and risk categories
What This Skill Does NOT Do:
- Diagnose disease (PRS is probabilistic, not deterministic)
- Replace clinical assessment or genetic counseling
- Account for non-genetic factors (lifestyle, environment)
- Provide treatment recommendations
What ships with it
3 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.
What this file has done since we first saw it
Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.
- 10d ago Changed · +20 lines fca4823713c4
- 1mo ago First seen · 289 lines · 72 tokens per session scan A a5a3d90e574f
tooluniverse-polygenic-risk-score is a skill published in the GitHub repository mims-harvard/ToolUniverse (1,744 stars, last pushed yesterday), licensed Apache-2.0. It adds 72 tokens to every session and 3,953 once invoked, about $0.0003 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.
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