dismech: Skill for Claude Code

.claude/skills/review-hypothesis-exploration/SKILL.md

review-hypothesis-exploration is a skill for Claude Code, Codex from monarch-initiative/dismech. It costs 66 tokens per session (1,950 once invoked), scanned A, original, BSD-3-Clause.

A review workflow for checking a generated scientific report about one possible disease mechanism against its cited research. It records the assessment in a structured YAML file.

In plain words
What is it for?
Use it to assess reports from OpenScientist, Kosmos, or similar providers, verify important claims against original research papers, and record a source-linked verdict for each claim.
Why use it?
It prevents an AI-generated research lead from being treated as established fact. It also separates evidence that directly supports a claim from evidence that only makes it plausible, qualifies it, or contradicts it.

Skill for Claude CodeCodex

Written for Claude Code and Codex: installed under .claude/, but also agents/openai.yaml present.

This is monarch-initiative/dismech's own configuration. It tells Claude Code and Codex how to work on dismech itself, so it is not a mod to install elsewhere. Copy it as a starting point and replace the rules that are about this project. Everything dismech configures →

Reuse

Borrowing it

Nothing to install: this file belongs to monarch-initiative/dismech. Take a copy, put it at the same path in your own repository, and replace the rules that are about this project with yours.

Copy the file
curl -O https://raw.githubusercontent.com/monarch-initiative/dismech/main/.claude/skills/review-hypothesis-exploration/SKILL.md
Clone the repo
git clone --depth 1 https://github.com/monarch-initiative/dismech

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for review-hypothesis-exploration

README.md
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Your own site
<a href="https://agentmods.dev/skills/monarch-initiative/dismech/review-hypothesis-exploration"><img src="https://agentmods.dev/badge/skills/monarch-initiative/dismech/review-hypothesis-exploration/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for review-hypothesis-exploration

Your own site · 80×15
<a href="https://agentmods.dev/skills/monarch-initiative/dismech/review-hypothesis-exploration"><img src="https://agentmods.dev/badge/skills/monarch-initiative/dismech/review-hypothesis-exploration.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 66 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,950 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Output Handling · line 64
    Model output is used without validation or sanitization. Unvalidated output injected into downstream contexts (SQL, shell, HTML) enables injection attacks and arbitrary code execution.
    Fix: Validate and sanitize all model output before using it in downstream contexts. Use parameterized queries for SQL, shell quoting for commands, and HTML encoding for web output.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00066 $0.01950
Opus 5 $0.00033 $0.00975
Sonnet 5 $0.00013 $0.00390
Haiku 4.5 $0.00007 $0.00195

Measured 8d ago against content hash d0899912f215, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

review-hypothesis-exploration scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 8d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

.claude/skills/review-hypothesis-exploration/SKILL.md · 139 lines

How it starts

The opening of the file, as written. The whole thing — 139 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Review Hypothesis Exploration

Treat a provider report as a research lead, not as a source of truth. Assess the report's reasoning and claims without automatically promoting its claims into a disorder YAML.

Assess one report

  1. Locate the raw report at kb/hypotheses/<Disease>/<hypothesis_id>/<provider>.md and identify the hypothesis directory, provider slug, and any provider artifact bundle. Read the report and inventory before judging the run.
  2. Inventory every material data source in data_sources, including databases searched with no result. Distinguish CITED_NOT_ACCESSED, ACCESSED, SEARCHED_NO_RESULT, and UNVERIFIABLE; a proposed future dataset is not an accessed input. Preserve a committed query/response or search-log artifact for ACCESSED and SEARCHED_NO_RESULT. Verify each accession with just verify-datasets --accession <CURIE> where supported, then separately check disease, tissue, cohort, organism, and assay relevance. Resolution does not establish relevance.
  3. Inventory every claimed computation in analyses. Trace input data-source IDs through method, software/version, parameters, code/environment, and outputs to the assessment claims the report attributes to that analysis; status and auditability determine whether execution actually supports them. Use SUCCEEDED only when inspectable artifacts substantiate execution; otherwise use PARTIAL, REPORTED_ONLY, FAILED, or SKIPPED as appropriate.
  4. Treat tool availability and fallback as evidence-quality facts. If retrieval, a data lake, or a scientific tool failed, record the failure and any fallback; do not silently treat a literature-only or model-knowledge fallback as a provider analysis or independent result. Biomni is disabled at repository entry points unless DISMECH_ENABLE_BIOMNI=1; do not bypass that opt-in. Without it, Biomni must also remain unavailable to automatic provider fallback. The hypothesis runner's dry-run command inspection is safe without the opt-in.
  5. Check the report's consequential claims against the cited primary literature. Distinguish direct support, external plausibility, qualification, and contradiction. Check taxonomic level, disease/model context, directionality, and causal versus correlational language.
  6. Create one authoritative YAML sidecar per provider and assessor at assessments/<provider>-assessment-by-<assessor>.yaml. Use a lowercase, hyphenated assessor slug (for example, openai-5-pro).
  7. Include the relative source_report, hypothesis_id, an overall verdict, and claim-level dispositions. For every assessment claim, use a short report_quote copied verbatim from the provider report and explain the assessment in rationale; attach analysis_ids only to claims the report attributes to those analyses, and use status/auditability to state whether execution supports them.
  8. Add an optional Markdown narrative and/or PDF using the same stem when it helps human review. The YAML remains authoritative; the rendered artifacts must be listed in artifacts.
  9. Apply the hypothesis artifact policy in docs/hypothesis-report-assessments.md: commit manifests, code, environment specifications, and small derived outputs; keep large/raw, controlled, or credential-bearing data outside Git and record whether each artifact is committed, external, local-only, missing, or not produced. Structured paths must be non-empty files beneath artifact_root: ../<provider>_artifacts. For a computational bundle, require canonical MANIFEST.yaml, run just validate-hypothesis-analysis-run <report> <artifact_dir>, and replay the saved code separately; the validator does not execute generated code. Confirm that report frontmatter has an artifact_manifest_sha256 binding to the exact current manifest bytes; a manifest edit makes an older report stale. If you correct provider code or results after its response, record the exact correction and before/after hashes in the manifest, replay it independently, and keep the provider analysis at most PARTIAL until the provider reruns or attests the corrected bytes. Never stamp a stale provider report onto an assessor-corrected bundle merely to make the gate pass.
  10. Keep a report-review citation as context only. Promote a paper-derived claim to the disease YAML only after normal reference-cache and evidence validation. Never hand-edit references_cache/*.md; use just fetch-reference <ID>.
  11. Validate the sidecar:

Read the full file on GitHub · 139 lines

Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 8d ago Changed · +97 lines · +16 tokens per session d0899912f215
  2. 12d ago First seen · 42 lines · 50 tokens per session scan A 4a83a8794d4e

Subscribe to this mod's changes

review-hypothesis-exploration is a skill published in the GitHub repository monarch-initiative/dismech (61 stars, last pushed today), licensed BSD-3-Clause. It adds 66 tokens to every session and 1,950 once invoked, about $0.0003 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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