spatial-modality-integrate

spatial-modality-integrate is a skill for Claude Code, Codex from ShangBioLab/SpatialClaw. It costs 54 tokens per session (3,040 once invoked), scanned A, original, Apache-2.0.

A spatial transcriptomics analysis skill for finding regions with similar biological activity in tissue samples. It supports DeepST for one sample or several samples, and PearlST for one sample with optional tissue-image information.

In plain words
What is it for?
Use it to identify tissue domains from spatial transcriptomics data or combine multiple samples with DeepST.
Why use it?
It removes the need to adapt separate research scripts and their directory requirements for each analysis method.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to identify tissue domains from spatial transcriptomics data or combine multiple samples with DeepST.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/shangbiolab/spatialclaw/spatial-modality-integrate
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add ShangBioLab/SpatialClaw --skill spatial-modality-integrate
Clone the repo
git clone --depth 1 https://github.com/ShangBioLab/SpatialClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for spatial-modality-integrate

README.md
[![agentmods](https://agentmods.dev/badge/skills/shangbiolab/spatialclaw/spatial-modality-integrate/github.svg)](https://agentmods.dev/skills/shangbiolab/spatialclaw/spatial-modality-integrate)
Your own site
<a href="https://agentmods.dev/skills/shangbiolab/spatialclaw/spatial-modality-integrate"><img src="https://agentmods.dev/badge/skills/shangbiolab/spatialclaw/spatial-modality-integrate/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for spatial-modality-integrate

Your own site · 80×15
<a href="https://agentmods.dev/skills/shangbiolab/spatialclaw/spatial-modality-integrate"><img src="https://agentmods.dev/badge/skills/shangbiolab/spatialclaw/spatial-modality-integrate.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 54 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,040 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00054 $0.03040
Opus 5.5 $0.00022 $0.01216
Sonnet 5.5 $0.00011 $0.00608
Haiku 4.5 $0.00005 $0.00304

Measured 1mo ago against content hash 8a3692d2afff, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

spatial-modality-integrate scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 1mo ago.

The scan reads SKILL.md. This mod also ships 2 executable files (spatial_modality_integrate.py, test_spatial_modality.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/spatial/spatial-modality-integrate/SKILL.md · 282 lines

How it starts

The opening of the file, as written. The whole thing — 282 lines — stays where its author put it; the contents beside it link to each section on GitHub.

🧠🔬 Spatial Modality Integrate

You are Spatial Modality Integrate, a SPATIALCLAW spatial analysis skill with two backends:

  • DeepST for single-sample domain identification and same-modality multi-sample integration
  • PearlST for single-sample spatial transcriptomics with optional Visium histology features

Your role is to keep the CLI contract consistent with other skills while preserving the real upstream input assumptions: sample directories, not loose single-file ad hoc invocation.

Why This Exists

  • Without it: Users have to manually translate DeepST and PearlST's repository-specific scripts, directory assumptions, and undocumented defaults into one-off notebooks.
  • With it: One standard SPATIALCLAW skill exposes both methods through a stable CLI, reproducible outputs, and method-aware reports.
  • Why SPATIALCLAW: The skill keeps the standard --input entry for single-sample runs, and only uses --input-list as the alternative input path for DeepST integration mode.

Core Capabilities

  1. DeepST single-sample domain identification from one spatial sample directory
  2. DeepST multi-sample integration from a text file listing sample directories
  3. PearlST single-sample analysis with PDE denoising, alpha-complex graph construction, and WARGA training
  4. Optional morphology-aware modeling when tissue images are available
  5. Standardized reporting via report.md, metadata.json, figures, and .h5ad outputs

Input Contract

This skill is directory-only.

Mode Required CLI Purpose
Single sample --input /path/to/sample --output <dir> Standard SPATIALCLAW input pattern for both DeepST and PearlST
Integration --mode integration --input-list samples.txt --output <dir> Alternative multi-sample input pattern for DeepST only

Important Constraints

  • --input must point to a sample directory, not a single file
  • --input-list must point to a text file containing one sample directory per line
  • Runs use real sample directories or an input-list file.
  • --method pearlst currently supports single-sample mode only
  • This skill is for same-modality spatial analysis, not RNA + protein / ATAC cross-omics integration

Read the full file on GitHub · 282 lines

Files

What ships with it

2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 1mo ago First seen · 282 lines · 54 tokens per session scan A 8a3692d2afff

Subscribe to this mod's changes

spatial-modality-integrate is a skill published in the GitHub repository ShangBioLab/SpatialClaw (11 stars, last pushed 5mo ago), licensed Apache-2.0. It adds 54 tokens to every session and 3,040 once invoked, about $0.0002 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

Other skills, from other repositories

spatial-integrate

Load when removing batch effects from multi-batch spatial AnnData with PCA using Harmony, BBKNN, or Scanorama. Skip physical coordinate alignment (use spatial-register) and single-batch data (use spatial-domains).

TianGzlab/OmicsClaw · 50 tokens

Developmental Gene Panel Design Workflow

Panel design for DEVELOPING / dynamic systems (embryonic organs, differentiation, regeneration). The target experiment is usually a LATE / terminal stage, but the biology is a trajectory: terminal cell types are end-products of earlier lineage programs. A panel built from the target stage alone resolves terminal…

aristoteleo/PantheonOS · 129 tokens

Gene Panel Selection Workflow

End-to-end workflow for gene panel design in scRNA-seq and spatial transcriptomics, that should be STRICTLY followed: dataset understanding + smart downsampling + train/test splits, algorithmic selection (HVG/DE/RF/scGeneFit/SpaPROS), optimal sub-panel discovery (ARI vs size), biological completion with a stability…

aristoteleo/PantheonOS · 110 tokens

Spatial Omics Skills Index

Skills for spatial transcriptomics analysis including single-cell to spatial mapping (MOSCOT), 3D visualization (PyVista), and related spatial workflows.

aristoteleo/PantheonOS · 37 tokens

spatial-preprocess

Load when running the foundational spatial transcriptomics QC + filtering + normalisation + HVG + PCA + neighbour-graph + Leiden pipeline on a Visium / Xenium / generic spatial AnnData. Skip when raw FASTQs need converting first (use spatial-raw-processing); tissue-domain detection on already-preprocessed data (use…

TianGzlab/OmicsClaw · 73 tokens

spatial-condition

Load when comparing conditions on spatial AnnData using biological-sample pseudobulk PyDESeq2 or Wilcoxon, with sample, condition and cluster labels. Skip one-condition per-cluster DE (use spatial-de) and experiments without independent replicates.

TianGzlab/OmicsClaw · 55 tokens