atac-seq

atac-seq is a skill for Claude Code, Codex from zongtingwei/Bioclaw_Skills_Hub. It costs 34 tokens per session (1,058 once invoked), scanned A, original, MIT.

A workflow for analyzing bulk ATAC-seq data, a sequencing method that shows which parts of DNA are accessible to regulatory proteins. It covers quality checks, finding accessible regions, comparing samples, and studying possible regulatory motifs or footprints.

In plain words
What is it for?
Use it for ATAC-seq quality control, peak calling, accessibility counting, differential accessibility analysis, and motif or footprint follow-up.
Why use it?
It helps turn ATAC-seq reads into checked, comparable results while flagging poor-quality data before biological interpretation.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it for ATAC-seq quality control, peak calling, accessibility counting, differential accessibility analysis, and motif or footprint follow-up.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/zongtingwei/bioclaw_skills_hub/atac-seq
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add zongtingwei/Bioclaw_Skills_Hub --skill atac-seq
Clone the repo
git clone --depth 1 https://github.com/zongtingwei/Bioclaw_Skills_Hub

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for atac-seq

README.md
[![agentmods](https://agentmods.dev/badge/skills/zongtingwei/bioclaw_skills_hub/atac-seq/github.svg)](https://agentmods.dev/skills/zongtingwei/bioclaw_skills_hub/atac-seq)
Your own site
<a href="https://agentmods.dev/skills/zongtingwei/bioclaw_skills_hub/atac-seq"><img src="https://agentmods.dev/badge/skills/zongtingwei/bioclaw_skills_hub/atac-seq/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for atac-seq

Your own site · 80×15
<a href="https://agentmods.dev/skills/zongtingwei/bioclaw_skills_hub/atac-seq"><img src="https://agentmods.dev/badge/skills/zongtingwei/bioclaw_skills_hub/atac-seq.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 34 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,058 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00034 $0.01058
Opus 5 $0.00017 $0.00529
Sonnet 5 $0.00007 $0.00212
Haiku 4.5 $0.00003 $0.00106

Measured 12d ago against content hash e0bf8b5ec840, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

atac-seq scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 12d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/epigenomics-and-regulation/atac-seq/SKILL.md · 165 lines

How it starts

The opening of the file, as written. The whole thing — 165 lines — stays where its author put it; the contents beside it link to each section on GitHub.

ATAC Seq

Version Compatibility

Reference examples assume:

  • macs3 3.0+
  • samtools 1.18+
  • deepTools 3.5+

Verify the runtime first:

  • CLI: macs3 --version, samtools --version, bamCoverage --version

Overview

Use this skill when the user needs:

  • bulk ATAC-seq QC
  • peak calling
  • accessibility counting
  • differential accessibility
  • motif deviation or footprint follow-up

When To Use This Skill

  • the task is bulk ATAC-seq rather than ChIP-seq
  • TSS enrichment, fragment periodicity, or FRiP need review
  • the output should include peaks, counts, and downstream accessibility summaries

Quick Route

  • paired-end bulk ATAC: use BAMPE
  • call peaks without control using ATAC-specific settings
  • if TSS enrichment is poor, stop and flag data quality before interpretation

Progressive Disclosure

Prerequisites

Check Guidance
uniquely mapped reads >= 20M preferred for strong bulk ATAC
TSS enrichment > 7 acceptable, > 10 strong
FRiP > 0.2 often strong for good bulk ATAC

Expected Inputs

  • paired-end ATAC BAM or FASTQ
  • reference genome
  • sample groups for comparisons

Expected Outputs

  • results/peaks/sample_peaks.narrowPeak
  • results/matrix/consensus_peak_counts.tsv
  • results/diff_accessibility.tsv
  • figures/tss_enrichment.pdf
  • figures/fragment_size_distribution.pdf

Starter Pattern

macs3 callpeak \
  -t atac.bam \
  -f BAMPE \
  -g hs \
  -n sample \
  --nomodel \
  --shift -100 \
  --extsize 200 \
  -q 0.01 \
  --outdir results/peaks

Key Parameters

Parameter Typical value Notes
-f BAMPE paired-end ATAC should use fragment-aware mode
--nomodel on standard for ATAC
--shift -100 common Tn5 offset convention
--extsize 200 common first-pass extension
-q 0.01 starting FDR threshold

Read the full file on GitHub · 165 lines

Files

What ships with it

3 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 12d ago First seen · 165 lines · 34 tokens per session scan A e0bf8b5ec840

Subscribe to this mod's changes

atac-seq is a skill published in the GitHub repository zongtingwei/Bioclaw_Skills_Hub (26 stars, last pushed 5mo ago), licensed MIT. It adds 34 tokens to every session and 1,058 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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