Apply A-Evolve's agentic evolution methodology to improve AI agent performance across runs. Use when the user wants to diagnose agent failures, generate targeted skills from error patterns, evolve system prompts, or accumulate episodic knowledge. Works standalone or inside AutoResearchClaw pipelines. Triggers on…
Bioinformatics with Biopython for sequence manipulation, file parsing, BLAST, and phylogenetics. Use when working with DNA/RNA/protein sequences or biological databases.
Computational chemistry with RDKit for molecular analysis, descriptors, fingerprints, and substructure search. Use when working with SMILES, drug discovery, or cheminformatics tasks.
Structured scientific hypothesis generation from observations. Use when formulating testable hypotheses, competing explanations, or experimental predictions.
Systematic literature review methodology including search strategy, screening, and synthesis. Use when conducting literature reviews or writing background sections.
Publication-ready scientific figure design with matplotlib and seaborn. Use when creating journal submission figures with proper formatting, accessibility, and statistical annotations.
Run Flux Balance Analysis (FBA) and related constraint-based simulations using COBRApy. Covers standard FBA, parsimonious FBA (pFBA), Flux Variability Analysis (FVA), loopless FBA, gene/reaction knockouts, and carbon source swapping. Outputs flux distributions and CSV files.
Build or load a genome-scale metabolic model (GSMM) using COBRApy. Covers loading from BIGG, constructing minimal models from scratch, setting medium constraints, and exporting validated .json model files.
Validate a COBRApy genome-scale metabolic model for mass/charge balance, stoichiometric consistency, biomass producibility, dead-end metabolites, thermodynamic loops, and GPR rule formatting. Outputs a structured validation report with errors and warnings.
Plan publishable constraint-based metabolic modelling studies when the user has a broad biological or metabolic-engineering topic but no concrete dataset, organism, model, or hypothesis. Selects feasible BiGG/COBRA models, objectives, perturbations, analyses, metrics, figures, and risk controls before FBA code is…
Orchestrate the full metabolic flux analysis pipeline from model loading to phenotype prediction and publication figures. Triggers when the user provides an organism name, BIGG model ID, or custom reaction list and wants end-to-end metabolic modelling run automatically.
Orchestrate a statistical research pipeline centered on formal problem formulation, method proposal, theoretical analysis, experimental evaluation, comparison, and final result synthesis.
Validate statistical research outputs for formulation quality, method-to- problem alignment, theory presence, experimental evidence, fair comparison, artifact completeness, and final-claim consistency.