dual-disease-shared-transcriptome-biomarker-research-planner

dual-disease-shared-transcriptome-biomarker-research-planner is a skill for Claude Code, Codex from aipoch/medical-research-skills. It costs 197 tokens per session (3,489 once invoked), scanned A, original, MIT.

A research-planning guide for comparing two non-cancer diseases through shared patterns in large gene-expression datasets. It focuses on finding common genes or biological pathways and checking whether they have meaning in both diseases.

In plain words
What is it for?
Use it to plan studies with per-disease differential expression, shared-gene or pathway analysis, key-gene prioritisation, diagnostic testing, immune context, and independent validation in both diseases.
Why use it?
It gives a two-disease study a consistent structure from separate disease comparisons to shared-signal validation. This helps distinguish reproducible shared biology from an accidental overlap between datasets.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to plan studies with per-disease differential expression, shared-gene or pathway analysis, key-gene prioritisation, diagnostic testing, immune context, and independent validation in both diseases.

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Install with agentmods
npx agentmods add skills/aipoch/medical-research-skills/dual-disease-shared-transcriptome-biomarker-research-planner
About the project

Medical Research Agent Skills is a library of agent instructions for medical and biomedical research, covering evidence analysis, study protocol design, data analysis, and academic writing. Researchers use it to guide compatible coding agents through common scientific workflows. The catalogue contains many of the library's skills and commands.

aipoch/medical-research-skills · 1,860 stars · on GitHub · aipoch.com

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add aipoch/medical-research-skills --skill dual-disease-shared-transcriptome-biomarker-research-planner
Clone the repo
git clone --depth 1 https://github.com/aipoch/medical-research-skills

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for dual-disease-shared-transcriptome-biomarker-research-planner

README.md
[![agentmods](https://agentmods.dev/badge/skills/aipoch/medical-research-skills/dual-disease-shared-transcriptome-biomarker-research-planner/github.svg)](https://agentmods.dev/skills/aipoch/medical-research-skills/dual-disease-shared-transcriptome-biomarker-research-planner)
Your own site
<a href="https://agentmods.dev/skills/aipoch/medical-research-skills/dual-disease-shared-transcriptome-biomarker-research-planner"><img src="https://agentmods.dev/badge/skills/aipoch/medical-research-skills/dual-disease-shared-transcriptome-biomarker-research-planner/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

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Your own site · 80×15
<a href="https://agentmods.dev/skills/aipoch/medical-research-skills/dual-disease-shared-transcriptome-biomarker-research-planner"><img src="https://agentmods.dev/badge/skills/aipoch/medical-research-skills/dual-disease-shared-transcriptome-biomarker-research-planner.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 197 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,489 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00197 $0.03489
Opus 5 $0.00098 $0.01744
Sonnet 5 $0.00039 $0.00698
Haiku 4.5 $0.00020 $0.00349

Measured 9d ago against content hash 539a8590c65a, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

dual-disease-shared-transcriptome-biomarker-research-planner scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

awesome-med-research-skills/Protocol Design/dual-disease-shared-transcriptome-biomarker-research-planner/SKILL.md · 252 lines

How it starts

The opening of the file, as written. The whole thing — 252 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Source: https://github.com/aipoch/medical-research-skills

Dual-Disease Shared-Transcriptome Biomarker Research Planner

You are an expert dual-disease bulk-transcriptome biomedical research planner.

Task: Generate a complete, structured research design — not a literature summary, not a tool list. A real, executable study plan with four workload options and a recommended primary path.

This skill is for conventional dual-disease shared-biomarker papers built around bulk expression datasets and clinically interpretable or biologically coherent shared endpoints. Typical article logic includes: disease A vs control differential expression, disease B vs control differential expression, shared-signal intersection or justified concordance integration, PPI-based hub-gene prioritization, diagnostic assessment in each disease, shared clinical or biological interpretation, immune infiltration context, single-gene pathway follow-up, and optional independent validation in both disease contexts.


Input Validation

Valid input: [disease pair] + [shared biomarker direction OR shared hub-gene direction OR shared pathway direction] Optional additions: public-data-only, no wet lab, one final lead gene, immune angle, one shared pathway, preferred config level, target journal tier.

Examples:

  • "Intracranial aneurysm and abdominal aortic aneurysm. Want a shared hub-gene biomarker study with immune infiltration."
  • "Disease A plus Disease B. Need DEG to shared hub to one final lead gene with dual validation."
  • "Two cardiovascular diseases. Public data only. Standard and Advanced."
  • "Need one shared biomarker with pathway interpretation and no wet lab."

Out-of-scope — respond with the redirect below and stop:

  • Clinical trial protocols, dosing, prescribing, patient-specific treatment recommendations
  • Pure scRNA-only, MR-only, GWAS-only, or proteomics-only studies with no conventional bulk-transcriptome shared-biomarker backbone
  • Wet-lab-only studies with no computational planning framework
  • Single-disease requests with no shared-disease design objective
  • Non-biomedical / off-topic requests

Read the full file on GitHub · 252 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 252 lines · 197 tokens per session scan A 539a8590c65a

Subscribe to this mod's changes

dual-disease-shared-transcriptome-biomarker-research-planner is a skill published in the GitHub repository aipoch/medical-research-skills (1,860 stars, last pushed 1mo ago), licensed MIT. It adds 197 tokens to every session and 3,489 once invoked, about $0.0010 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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