qtl-colocalization-study-planner

qtl-colocalization-study-planner is a skill for Claude Code, Codex from aipoch/medical-research-skills. It costs 221 tokens per session (3,488 once invoked), scanned A, original, MIT.

A study-planning guide for testing whether a genetic disease signal and a molecular signal may come from the same underlying cause. It works with eQTL, pQTL, and sQTL data, which measure genetic effects on gene activity, protein levels, or RNA splicing, alongside GWAS results.

In plain words
What is it for?
Planning studies that compare GWAS loci with molecular QTL signals, prioritize candidate genes, apply colocalization or fine-mapping, and optionally add Mendelian randomization, SMR, or functional annotation.
Why use it?
It helps researchers connect population-level disease associations with possible genes, proteins, or regulatory mechanisms at a specific genomic region. The plan also keeps genetic ancestry, linkage between nearby variants, and follow-up evidence in view.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Planning studies that compare GWAS loci with molecular QTL signals, prioritize candidate genes, apply colocalization or fine-mapping, and optionally add Mendelian randomization, SMR, or functional annotation.

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Install with agentmods
npx agentmods add skills/aipoch/medical-research-skills/qtl-colocalization-study-planner
About the project

Medical Research Agent Skills is a library of agent instructions for medical and biomedical research, covering evidence analysis, study protocol design, data analysis, and academic writing. Researchers use it to guide compatible coding agents through common scientific workflows. The catalogue contains many of the library's skills and commands.

aipoch/medical-research-skills · 1,869 stars · on GitHub · aipoch.com

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add aipoch/medical-research-skills --skill qtl-colocalization-study-planner
Clone the repo
git clone --depth 1 https://github.com/aipoch/medical-research-skills

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for qtl-colocalization-study-planner

README.md
[![agentmods](https://agentmods.dev/badge/skills/aipoch/medical-research-skills/qtl-colocalization-study-planner/github.svg)](https://agentmods.dev/skills/aipoch/medical-research-skills/qtl-colocalization-study-planner)
Your own site
<a href="https://agentmods.dev/skills/aipoch/medical-research-skills/qtl-colocalization-study-planner"><img src="https://agentmods.dev/badge/skills/aipoch/medical-research-skills/qtl-colocalization-study-planner/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for qtl-colocalization-study-planner

Your own site · 80×15
<a href="https://agentmods.dev/skills/aipoch/medical-research-skills/qtl-colocalization-study-planner"><img src="https://agentmods.dev/badge/skills/aipoch/medical-research-skills/qtl-colocalization-study-planner.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 221 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,488 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00221 $0.03488
Opus 5 $0.00111 $0.01744
Sonnet 5 $0.00044 $0.00698
Haiku 4.5 $0.00022 $0.00349

Measured 9d ago against content hash 041b192045d9, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

qtl-colocalization-study-planner scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

awesome-med-research-skills/Protocol Design/qtl-colocalization-study-planner/SKILL.md · 328 lines

How it starts

The opening of the file, as written. The whole thing — 328 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Source: https://github.com/aipoch/medical-research-skills

QTL Colocalization Study Planner

You are an expert QTL–GWAS locus-integration study planner.

Task: Generate a complete, structured, execution-oriented colocalization study design for linking eQTL, pQTL, sQTL, or related molecular QTL signals with GWAS findings.

This skill is for users who want to move from a disease / trait / locus / gene-prioritization idea to a real colocalization research plan with:

  • a clarified locus-level question,
  • a best-fit study pattern,
  • candidate QTL and GWAS data architecture,
  • LD and ancestry alignment logic,
  • colocalization and optional fine-mapping modules,
  • candidate gene prioritization rules,
  • linked MR / SMR / functional-annotation follow-up,
  • figure and deliverable logic,
  • and four workload configurations with one recommended primary plan.

This skill is not a generic GWAS summary, not a pure MR template, and not a full manuscript writer.

It must always distinguish between:

  • whether the study is asking about a locus, a gene, a protein, a splice event, or a regulatory mechanism
  • what signal is GWAS-driven versus QTL-driven
  • what is shared-signal support versus mere locus overlap
  • what is candidate-gene prioritization versus causal proof
  • what is locus-level evidence versus genome-wide summary evidence
  • what is verified versus assumed versus unverified

Reference Module Integration

The references/ directory is not optional background material. It defines the operational rules that must be actively used while running this skill.

Use the reference modules as follows:

  • references/workload-configurations.md → use when generating Section B.
  • references/study-patterns.md → use when selecting the dominant colocalization design family in Section C.
  • references/dataset-recommendation-and-disclaimer.md → use whenever datasets, QTL resources, GWAS resources, repositories, or public atlases are mentioned in Sections D, E, and K.
  • references/analysis-modules.md → use when selecting the analysis flow in Sections D–F.
  • references/method-library.md → use when translating modules into concrete colocalization methods and linked follow-up methods in Sections E–F.
  • references/validation-evidence-hierarchy.md → use when designing the evidence ladder and claim-boundary logic in Sections G–I.
  • references/figure-deliverable-plan.md → use when defining figure logic and output package expectations in Section J.
  • references/literature-retrieval-and-citation.md → use when a literature-support layer is requested or when formal references are provided in Section K.
  • references/workflow-step-template.md → use to keep the workflow sequence consistent and to enforce the mandatory Dataset Disclaimer in Section D.

Read the full file on GitHub · 328 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 328 lines · 221 tokens per session scan A 041b192045d9

Subscribe to this mod's changes

qtl-colocalization-study-planner is a skill published in the GitHub repository aipoch/medical-research-skills (1,869 stars, last pushed today), licensed MIT. It adds 221 tokens to every session and 3,488 once invoked, about $0.0011 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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