write-protocol

write-protocol is a skill for Claude Code from Aperivue/medsci-skills. It costs 50 tokens per session (1,436 once invoked), scanned A, original, MIT.

A generator for medical research protocols intended for review by an IRB or ethics committee, the body that checks whether research involving people is ethically acceptable.

In plain words
What is it for?
It drafts the background, study design, sample-size justification, and statistical analysis sections, plus outlines for other required sections.
Why use it?
It gives researchers a structured starting draft while leaving institution-specific requirements clearly marked for completion.

Skill for Claude Code

Written for Claude Code: ${CLAUDE_SKILL_DIR} variable.

Part of the medsci-writing plugin — 7 skills shipped together

Good fit It drafts the background, study design, sample-size justification, and statistical analysis sections, plus outlines for other required sections.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/aperivue/medsci-skills/write-protocol
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add Aperivue/medsci-skills --skill write-protocol
Clone the repo
git clone --depth 1 https://github.com/Aperivue/medsci-skills

Made for: Claude Code.

Or install medsci-writing, the plugin that ships this one along with the rest of its 7 skills.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for write-protocol

README.md
[![agentmods](https://agentmods.dev/badge/skills/aperivue/medsci-skills/write-protocol/github.svg)](https://agentmods.dev/skills/aperivue/medsci-skills/write-protocol)
Your own site
<a href="https://agentmods.dev/skills/aperivue/medsci-skills/write-protocol"><img src="https://agentmods.dev/badge/skills/aperivue/medsci-skills/write-protocol/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for write-protocol

Your own site · 80×15
<a href="https://agentmods.dev/skills/aperivue/medsci-skills/write-protocol"><img src="https://agentmods.dev/badge/skills/aperivue/medsci-skills/write-protocol.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 50 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,436 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 2 findings, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Memory Poisoning · line 92
    Skill manipulates agent memory, state, or stored context. Memory corruption can alter personality, override safety rules, or cause unpredictable behavior.
    Fix: Protect agent memory and state from modification by untrusted content. Use read-only memory for critical instructions and validate all state changes.
  • medium Rogue Agent · line 8
    Skill establishes unauthorized persistence across sessions via cron jobs, startup scripts, or state files. Session persistence allows an attacker to maintain access beyond the current interaction.
    Fix: Remove any persistence mechanisms (cron jobs, startup scripts, state files). Skills should not maintain state across sessions without explicit user consent.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00050 $0.01436
Opus 5.5 $0.00020 $0.00574
Sonnet 5.5 $0.00010 $0.00287
Haiku 4.5 $0.00005 $0.00144

Measured 24d ago against content hash 46bd1e3a5913, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

write-protocol scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 24d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/write-protocol/SKILL.md · 124 lines

How it starts

The opening of the file, as written. The whole thing — 124 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Write-Protocol Skill

Draft the scientific core of an IRB/ethics protocol and leave institution-specific sections as [TODO] skeletons. Read both reference files before generating a protocol draft:

  • ${CLAUDE_SKILL_DIR}/references/protocol_template.md -- the 10-section structure, per-section guidance, and the [TODO] blocks for Sections 5-9
  • ${CLAUDE_SKILL_DIR}/references/ethics_checklist.md -- jurisdiction-specific ethical requirements

Inputs

Collect the required inputs before generating; ask for any that are missing.

  • Required: research question / hypothesis (specific, testable); study type (retrospective cohort, prospective cohort, cross-sectional, RCT, diagnostic accuracy, case-control, case series); target population (who, where, when); primary outcome; secondary outcomes (if any).
  • Optional: key references (DOIs or search terms); institution name (header and ethics guidance); regulatory context -- Korea (PIPA), US (HIPAA/Common Rule), EU (GDPR), other.

Use prior skill outputs directly when they exist; when they do not, ask the user or call the skill:

  • design-study: design recommendations, analysis unit, comparator design, validation strategy.
  • calc-sample-size: protocol/sample_size_justification.md (canonical IRB-ready prose) and protocol/sample_size_calc.{R,py} (reproducible code).
  • search-lit: Background references with verified citations.
  • define-variables: variable_operationalization.md -- literature-grounded definitions, cutoffs, DB-variable mappings for the Methods section. Precondition: if the study is observational and no operationalization artifact exists, call /define-variables before drafting Methods. Do not invent phenotype/cutoff definitions from the data dictionary inside this skill.

Protocol Structure -- 10 Sections

Core Sections (Fully Generated)

Section 1: Background and Rationale (400-600 words)

Full paragraphs, no bullet points, flowing from clinical context (disease burden, current practice) through the knowledge gap and rationale (what this study adds) to the research question or hypothesis. Call /search-lit if key references are not provided. Cite a reference only with a /search-lit-confirmed DOI or PMID; otherwise mark it [UNVERIFIED - NEEDS MANUAL CHECK].

Read the full file on GitHub · 124 lines

Files

What ships with it

3 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 24d ago Changed · -126 lines · -15 tokens per session 46bd1e3a5913
  2. 1mo ago Changed · -2 lines 8548d8bbebe1
  3. 1mo ago First seen · 252 lines · 65 tokens per session scan A 3d2041be27da

Subscribe to this mod's changes

write-protocol is a skill published in the GitHub repository Aperivue/medsci-skills (349 stars, last pushed 2d ago), licensed MIT. It adds 50 tokens to every session and 1,436 once invoked, about $0.0002 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

Related

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