atac-seq-clustering-performance-interpretation

atac-seq-clustering-performance-interpretation is a skill for Claude Code, Codex from HolobiomicsLab/asb-skill-collections. It costs 45 tokens per session (1,724 once invoked), scanned A, original, Apache-2.0.

A method for comparing how well clustering methods group single-cell ATAC-seq data, which measures accessible DNA regions in individual cells.

In plain words
What is it for?
Use it to extract and compare measures such as NMI, ARI, and purity, then assess which clustering approach or configuration fits your data.
Why use it?
It helps put results from different methods and published studies on the same footing instead of judging a method from one experiment.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to extract and compare measures such as NMI, ARI, and purity, then assess which clustering approach or configuration fits your data.

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Install with agentmods
npx agentmods add skills/holobiomicslab/asb-skill-collections/atac-seq-clustering-performance-interpretation
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add HolobiomicsLab/asb-skill-collections --skill atac-seq-clustering-performance-interpretation
Clone the repo
git clone --depth 1 https://github.com/HolobiomicsLab/asb-skill-collections

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

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README.md
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Your own site
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<a href="https://agentmods.dev/skills/holobiomicslab/asb-skill-collections/atac-seq-clustering-performance-interpretation"><img src="https://agentmods.dev/badge/skills/holobiomicslab/asb-skill-collections/atac-seq-clustering-performance-interpretation.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 45 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,724 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00045 $0.01724
Opus 5 $0.00023 $0.00862
Sonnet 5 $0.00009 $0.00345
Haiku 4.5 $0.00005 $0.00172

Measured 10d ago against content hash 0738e25f9c17, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-10, from the pricing page.

Security

Grade A, and why

atac-seq-clustering-performance-interpretation scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 10d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

collections/epigenomics/v1/skills/atac-seq-clustering-performance-interpretation/SKILL.md · 95 lines

How it starts

The opening of the file, as written. The whole thing — 95 lines — stays where its author put it; the contents beside it link to each section on GitHub.

atac-seq-clustering-performance-interpretation

Summary

Systematically extract, tabulate, and interpret clustering performance metrics (NMI, ARI, purity) from single-cell ATAC-seq benchmark studies to compare method performance across datasets. This skill enables practitioners to contextualize the relative strengths of dimensionality reduction + clustering pipelines (e.g., kmers+PCA vs. SnapATAC) against published benchmarks.

When to use

When you need to assess whether a given ATAC-seq clustering method (or variant) is competitive on your data or when evaluating which published method to adopt. Specifically, apply this skill when you have access to published benchmark results (preprint or paper) that report clustering accuracy scores (NMI, ARI, purity) across multiple datasets, and you want to extract, standardize, and rank those metrics to determine which method or configuration (e.g., motif type, dimensionality reduction strategy) achieves best clustering performance.

When NOT to use

  • Your goal is motif discovery or TF binding annotation rather than cell clustering—chromVAR is complementary to clustering and better suited for annotating TF motif usage in cells and clusters.
  • You are comparing methods on a dataset not included in the published benchmark—extrapolation beyond reported datasets requires additional validation.
  • Clustering metrics are unavailable or unreported in your source literature—this skill requires access to published quantitative benchmarks, not qualitative claims.

Inputs

  • Published benchmark tables or supplementary data reporting clustering accuracy metrics (NMI, ARI, purity) from single-cell ATAC-seq methods
  • Method names and variant specifications (e.g., 'chromVAR kmers + PCA', 'chromVAR motifs + PCA', 'SnapATAC')
  • Dataset identifiers and their associated accuracy scores

Outputs

  • TSV or CSV table with methods as rows, datasets as columns, and clustering accuracy scores as cell values
  • Summary statistics table (mean, median, rank per method across datasets)
  • Comparative analysis document stating which method/variant achieves best clustering performance and quantifying performance gaps

Read the full file on GitHub · 95 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 10d ago First seen · 95 lines · 45 tokens per session scan A 0738e25f9c17

Subscribe to this mod's changes

atac-seq-clustering-performance-interpretation is a skill published in the GitHub repository HolobiomicsLab/asb-skill-collections (15 stars, last pushed 5d ago), licensed Apache-2.0. It adds 45 tokens to every session and 1,724 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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