python-pandas-data-manipulation

python-pandas-data-manipulation is a skill for Claude Code, Codex from HolobiomicsLab/asb-skill-collections. It costs 67 tokens per session (1,449 once invoked), scanned A, original, Apache-2.0.

A Python and pandas workflow for transforming tabular genomic contact-frequency data. It groups genomic distances into logarithmically spaced bins, smooths and aggregates the measurements, and exports a cleaned table for later use.

In plain words
What is it for?
Processing TSV or CSV tables with genomic distance, contact frequency, and validity-count columns before visualization or further analysis.
Why use it?
Raw distance tables can be difficult to compare or plot because distances span many scales and contain uneven measurements. This prepares them as a consistent contact-frequency curve, where contact frequency describes how often genomic regions interact at a given distance.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Processing TSV or CSV tables with genomic distance, contact frequency, and validity-count columns before visualization or further analysis.

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Install with agentmods
npx agentmods add skills/holobiomicslab/asb-skill-collections/python-pandas-data-manipulation
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add HolobiomicsLab/asb-skill-collections --skill python-pandas-data-manipulation
Clone the repo
git clone --depth 1 https://github.com/HolobiomicsLab/asb-skill-collections

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

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README.md
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Per session 67 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,449 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to medium

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • medium Output Handling · line 79
    Output size or generation rate is not bounded. Unbounded output enables denial-of-service through resource exhaustion, log flooding, or context-window stuffing.
    Fix: Set explicit limits on output length, generation count, and rate. Use max_tokens and truncation to prevent unbounded output.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00067 $0.01449
Opus 5 $0.00034 $0.00724
Sonnet 5 $0.00013 $0.00290
Haiku 4.5 $0.00007 $0.00145

Measured 3d ago against content hash b2fd93cbcaf1, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-09, from the pricing page.

Security

Grade A, and why

python-pandas-data-manipulation scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 3d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

collections/epigenomics/v1/skills/python-pandas-data-manipulation/SKILL.md · 98 lines

How it starts

The opening of the file, as written. The whole thing — 98 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Python pandas data manipulation

Summary

Use Python and pandas to load, transform, and export tabular datasets (TSV/CSV) containing precomputed genomic statistics, applying binning, smoothing, and aggregation operations to prepare contact frequency curves for downstream analysis.

When to use

You have precomputed expected contact frequency tables (TSV format with columns like dist_bp, contact_frequency, n_valid) and need to apply log-binning and smoothing to group distance values into log-spaced bins, aggregate statistics within each bin, and export a cleaned, annotated output table for visualization or further analysis.

When NOT to use

  • Input is already a log-binned or aggregated contact frequency curve; re-binning would introduce redundant or conflicting bin boundaries.
  • Contact frequency data is in cooler (.cool/.mcool) HDF5 format; use cooler API methods directly rather than manual TSV export and pandas re-import.
  • Analysis goal is real-time or streaming; pandas requires full dataset in memory.

Inputs

  • TSV table with columns: dist_bp (genomic distance), contact_frequency, n_valid (bin size/validity counts)
  • Logarithmic binning parameters (e.g., log base, minimum/maximum bin edges)
  • Optional: precomputed smoothing kernel or smoothing algorithm specification

Outputs

  • Log-binned TSV table with columns: dist_bp (bin representative or range), count.avg.smoothed (mean contact frequency per bin), and bin statistics (e.g., bin size, variance)
  • Optionally: metadata or column headers documenting bin structure and smoothing method

How to apply

Load the precomputed expected_cis table from TSV format into a pandas DataFrame. Apply logarithmic binning to group genomic distances into log-spaced bins using the cooltools logbin_expected function or equivalent binning logic. Compute aggregated statistics within each bin (e.g., mean smoothed contact frequency, bin counts) using pandas groupby and aggregation operations. Generate an output DataFrame with columns including binned distance, mean smoothed contact frequency, and bin statistics. Ensure numeric precision and proper column headers, then export to TSV format for downstream use.

Read the full file on GitHub · 98 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 3d ago First seen · 98 lines · 67 tokens per session scan A b2fd93cbcaf1

Subscribe to this mod's changes

python-pandas-data-manipulation is a skill published in the GitHub repository HolobiomicsLab/asb-skill-collections (15 stars, last pushed 4d ago), licensed Apache-2.0. It adds 67 tokens to every session and 1,449 once invoked, about $0.0003 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-06.

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