r-package-champ-usage

r-package-champ-usage is a skill for Claude Code, Codex from HolobiomicsLab/asb-skill-collections. It costs 67 tokens per session (1,982 once invoked), scanned A, original, Apache-2.0.

A guide to ChAMP, an R package for DNA methylation array analysis. It works with 450K or EPIC array files and supports quality filtering, normalization, batch correction, methylation-region analysis, and gene-set analysis.

In plain words
What is it for?
It helps import IDAT files or beta-value tables, check probe counts, correct technical batch differences, find differentially methylated regions, and run gene-set analysis.
Why use it?
It provides a defined path from raw array measurements to cleaned and analyzed methylation results.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit It helps import IDAT files or beta-value tables, check probe counts, correct technical batch differences, find differentially methylated regions, and run gene-set analysis.

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Install with agentmods
npx agentmods add skills/holobiomicslab/asb-skill-collections/r-package-champ-usage
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add HolobiomicsLab/asb-skill-collections --skill r-package-champ-usage
Clone the repo
git clone --depth 1 https://github.com/HolobiomicsLab/asb-skill-collections

Made for: Claude Code, Codex.

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README.md
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Per session 67 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,982 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to medium

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • medium analysis-evasion · line 1
    Suspicious Unicode normalization or mixed-script content
    Fix: Review the flagged content for security risks. Ensure no credentials, secrets, or sensitive data are exposed.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00067 $0.01982
Opus 5 $0.00034 $0.00991
Sonnet 5 $0.00013 $0.00396
Haiku 4.5 $0.00007 $0.00198

Measured 6d ago against content hash e71b4b9e3343, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

r-package-champ-usage scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

collections/epigenomics/v1/skills/r-package-champ-usage/SKILL.md · 108 lines

How it starts

The opening of the file, as written. The whole thing — 108 lines — stays where its author put it; the contents beside it link to each section on GitHub.

R package ChAMP usage

Summary

ChAMP is an R package for comprehensive DNA methylation array analysis, supporting HumanMethylation450 (450K) and EPIC array types from data loading through gene set enrichment analysis. Use this skill when you have .idat files or beta-valued methylation matrices and need to perform quality control, normalization, batch correction, and downstream statistical analysis.

When to use

When you have raw methylation array data (450K or EPIC format) in .idat files or as a beta-valued matrix and need to conduct a complete analysis pipeline including data import, quality filtering, normalization, batch effect correction, DMR detection, or gene set enrichment. Specifically use champ.load() when you need to verify pre-filter probe counts (485,512 for 450K arrays, 867,531 for EPIC arrays) before applying quality-based filtering.

When NOT to use

  • Input data is already a fully normalized and filtered feature table from another pipeline (e.g., already processed by minfi, RnBeads, or IMA); ChAMP assumes raw or minimally processed .idat or beta matrix input.
  • You are analyzing non-array methylation data (e.g., WGBS, targeted bisulfite sequencing) — ChAMP is designed specifically for Illumina beadarray platforms (450K and EPIC).
  • Your data contains fewer probes than expected or is from an unsupported array type (e.g., mouse arrays require ChAMPdata to be installed separately).

Inputs

  • .idat files (raw methylation array data for 450K or EPIC arrays)
  • beta-valued matrix (methylation β-values)
  • sample metadata and phenotype information

Outputs

  • Filtered and normalized methylation matrix (probe × sample)
  • Quality control plots and reports
  • Batch-corrected methylation data
  • DMR detection results
  • Gene set enrichment analysis results

How to apply

Install ChAMP (version ≥2.29.1) along with ChAMPdata (≥2.23.1) from GitHub or Bioconductor. Load your methylation data using champ.load() or champ.import() functions, specifying the array type (450K or EPIC). Verify pre-filter probe counts match expected values for your array type. Apply quality control using ChAMP's QC functions, then proceed through the analysis pipeline: choose a Type-2 probe correction method (SWAN, PBC, or default BMIQ), apply Functional Normalization if needed, correct batch effects using SVD inspection and ComBat correction, adjust for cell-type heterogeneity via RefbaseEWAS if applicable, and finally perform DMR detection (Probe Lasso, Bumphunter, or DMRcate) or gene set enrichment analysis. The modular design allows selection of methods appropriate to your study design.

Read the full file on GitHub · 108 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 6d ago First seen · 108 lines · 67 tokens per session scan A e71b4b9e3343

Subscribe to this mod's changes

r-package-champ-usage is a skill published in the GitHub repository HolobiomicsLab/asb-skill-collections (15 stars, last pushed yesterday), licensed Apache-2.0. It adds 67 tokens to every session and 1,982 once invoked, about $0.0003 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-06.

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