scatac-seq-peak-matrix-export

scatac-seq-peak-matrix-export is a skill for Claude Code, Codex from HolobiomicsLab/asb-skill-collections. It costs 66 tokens per session (1,285 once invoked), scanned A, original, Apache-2.0.

A procedure for exporting a peak-by-cell accessibility matrix from an ArchR project into a format understood by STREAM. A peak-by-cell matrix records how accessible genomic regions are in individual cells.

In plain words
What is it for?
It is for exporting completed single-cell ATAC-seq peak data after peak calling and cell annotation, before STREAM analysis.
Why use it?
It avoids rebuilding the matrix when using STREAM for trajectory analysis or sharing accessibility data with collaborators.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit It is for exporting completed single-cell ATAC-seq peak data after peak calling and cell annotation, before STREAM analysis.

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Install with agentmods
npx agentmods add skills/holobiomicslab/asb-skill-collections/scatac-seq-peak-matrix-export
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add HolobiomicsLab/asb-skill-collections --skill scatac-seq-peak-matrix-export
Clone the repo
git clone --depth 1 https://github.com/HolobiomicsLab/asb-skill-collections

Made for: Claude Code, Codex.

Wrote this? Show the measurements

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README.md
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Per session 66 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,285 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to medium

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • medium Output Handling · line 79
    Output size or generation rate is not bounded. Unbounded output enables denial-of-service through resource exhaustion, log flooding, or context-window stuffing.
    Fix: Set explicit limits on output length, generation count, and rate. Use max_tokens and truncation to prevent unbounded output.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00066 $0.01285
Opus 5 $0.00033 $0.00642
Sonnet 5 $0.00013 $0.00257
Haiku 4.5 $0.00007 $0.00128

Measured 6d ago against content hash 1f03d6ac964d, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

scatac-seq-peak-matrix-export scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

collections/epigenomics/v1/skills/scatac-seq-peak-matrix-export/SKILL.md · 97 lines

How it starts

The opening of the file, as written. The whole thing — 97 lines — stays where its author put it; the contents beside it link to each section on GitHub.

scatac-seq-peak-matrix-export

Summary

Export a peak-by-cell accessibility matrix from a processed ArchR project into STREAM-compatible format for downstream trajectory analysis. This skill bridges scATAC-seq peak quantification and external trajectory inference tools.

When to use

After completing peak calling and cell annotation in an ArchR project, when you intend to perform trajectory analysis using STREAM rather than ArchR's native monocle3 or Slingshot integrations, or when you need to share peak-by-cell matrices with collaborators using STREAM pipelines.

When NOT to use

  • Your downstream analysis uses monocle3 or Slingshot, which ArchR directly supports via addMonocleTrajectory or addSlingShotTrajectories without intermediate export.
  • You require gene expression matrices rather than chromatin accessibility; use addGeneExpressionMatrix instead.
  • Your peak matrix has already been exported or you are working with pre-computed accessibility matrices from external sources.

Inputs

  • ArchR project object (containing peak calls and cell annotations)
  • Cell metadata with trajectory or treatment information

Outputs

  • Peak-by-cell matrix in STREAM-compatible format (CSV or TSV)
  • Matrix with peaks as rows and cells as columns

How to apply

Load a processed ArchR project object containing peak calls and cell metadata annotations. Call the exportPeakMatrixForSTREAM function on the ArchR project to generate a peak-by-cell matrix formatted for STREAM compatibility. The function outputs a matrix where rows represent peaks (genomic loci) and columns represent single cells, with binary or continuous accessibility values. Write the resulting matrix to a file in STREAM-compatible format (typically CSV or TSV). Verify the output matrix dimensions match your expected peak and cell counts, and confirm the file format matches STREAM's input requirements.

  • ArchR (Primary R package for scATAC-seq processing; provides the exportPeakMatrixForSTREAM function to generate STREAM-compatible peak matrices.) — https://github.com/GreenleafLab/ArchR
  • STREAM (Downstream trajectory analysis tool that accepts peak-by-cell matrices exported from ArchR.)
  • monocle3 (Alternative trajectory analysis tool directly supported by ArchR; use if STREAM export is not needed.)
  • Slingshot (Alternative trajectory analysis tool directly supported by ArchR; use if STREAM export is not needed.)

Read the full file on GitHub · 97 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 6d ago First seen · 97 lines · 66 tokens per session scan A 1f03d6ac964d

Subscribe to this mod's changes

scatac-seq-peak-matrix-export is a skill published in the GitHub repository HolobiomicsLab/asb-skill-collections (15 stars, last pushed 2d ago), licensed Apache-2.0. It adds 66 tokens to every session and 1,285 once invoked, about $0.0003 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-06.

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