ToolUniverse is a collection of tools, interfaces, and supporting components for building AI systems that perform scientific work. It is for developers creating AI scientist agents that use APIs, databases, machine-learning tools, and domain-specific utilities. The catalogue includes skills, commands, an MCP server, an agent, and a hook for working with the ecosystem.
Getting it into your agent
One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.
npx skills add mims-harvard/ToolUniverse --skill tooluniverse-sequence-analysisgit clone --depth 1 https://github.com/mims-harvard/ToolUniverseWrote this? Show the measurements
A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.
[](https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-sequence-analysis)<a href="https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-sequence-analysis"><img src="https://agentmods.dev/badge/skills/mims-harvard/tooluniverse/tooluniverse-sequence-analysis/github.svg" alt="Measured on agentmods" height="20"></a>Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.
<a href="https://agentmods.dev/skills/mims-harvard/tooluniverse/tooluniverse-sequence-analysis"><img src="https://agentmods.dev/badge/skills/mims-harvard/tooluniverse/tooluniverse-sequence-analysis.svg" alt="Reviewed on agentmods" width="80" height="20"></a>- NVIDIA SkillSpector warn
SkillSpector: 1 finding, up to medium
These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →
- medium analysis-evasion · line 1 Suspicious Unicode normalization or mixed-script contentFix: Review the flagged content for security risks. Ensure no credentials, secrets, or sensitive data are exposed.
What it costs to keep this loaded
Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.
| Model | Per session | Once invoked |
|---|---|---|
| Fable 5.1 | $0.00076 | $0.06806 |
| Opus 5.5 | $0.00030 | $0.02722 |
| Sonnet 5.5 | $0.00015 | $0.01361 |
| Haiku 4.5 | $0.00008 | $0.00681 |
Grade A, and why
tooluniverse-sequence-analysis scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 1mo ago.
A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.
Nothing flagged
None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.
How it starts
The opening of the file, as written. The whole thing — 382 lines — stays where its author put it; the contents beside it link to each section on GitHub.
Biological Sequence Analysis
⚠️ TOP-OF-MIND RULE: Trimmomatic "reads completely discarded" = F + R + 2*D, summed across samples
When a question asks about Trimmomatic "reads completely discarded" / "reads thrown out" /
"reads not in any output", do NOT report the Dropped field alone. Dropped counts
PAIRS where both mates failed; each pair = 2 individual reads. Plus the Forward-only and
Reverse-only buckets also discard one read per pair.
reads_discarded = sum over samples of (Forward_Only + Reverse_Only + 2 * Dropped)
❌ WRONG: sum(Dropped per sample) — typically reports ~thousands, GT is 100×+ higher
✅ RIGHT: sum(F + R + 2*D per sample)
Full counter table is in the FASTQ section below.
RULE ZERO — Check for pre-computed results FIRST
Before following any instruction below, scan the data folder for:
*_executed.ipynb→ read withtu run read_executed_notebook '{"data_folder":"<path>","search":"<keyword>"}'and cite its cell outputs as the authoritative answer- Pre-computed result files (CSV/TSV with names like
*results*,*deseq*,*enrich*,*stats*,*_simplified.csv) → read directly and report the requested value - Canonical analysis scripts (
analysis.R,run_*.py,find_*.R,*.Rmd) → execute as-is and read the output
Only follow this skill's re-analysis recipe below if none of the above exist. Re-running from raw data produces different numbers than the published answer and is much slower (often 5-10× turn count).
Retrieve, annotate, and compare biological sequences from NCBI, Ensembl, and UniProt. Covers nucleotide search, sequence fetching, gene summaries, ortholog discovery, and protein sequence extraction.
FASTQ QC, Trimmomatic, and read alignment (when raw reads are present)
When the data folder has *.fastq files and the question involves Trimmomatic, BWA, samtools, FastQC, or coverage depth, this skill is the entry point — but the actual work is shell-level (no specific ToolUniverse data tool).
What ships with it
4 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.
What this file has done since we first saw it
Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.
- 1mo ago Changed · +6 lines f7a04b056d6f
- 1mo ago First seen · 376 lines · 76 tokens per session scan A 55fc42320915
tooluniverse-sequence-analysis is a skill published in the GitHub repository mims-harvard/ToolUniverse (1,744 stars, last pushed yesterday), licensed Apache-2.0. It adds 76 tokens to every session and 6,806 once invoked, about $0.0003 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.
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