bio-data-visualization-sequence-logos

bio-data-visualization-sequence-logos is a skill for Claude Code, Codex from PKU-YuanGroup/OpenAI4S. It costs 88 tokens per session (3,390 once invoked), scanned A, a copy of bio-data-visualization-sequence-logos, MIT.

A guide to making sequence logos: stacks of DNA, RNA, or protein letters where taller stacks show positions that are more conserved. It covers frequency, probability, and information-content encodings.

In plain words
What is it for?
Use it to visualize binding motifs, splice-site patterns, CRISPR spacers, and other aligned sequences.
Why use it?
It helps prevent misleading motif charts by making the letter heights and background frequencies match the intended biological interpretation.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to visualize binding motifs, splice-site patterns, CRISPR spacers, and other aligned sequences.

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Install with agentmods
npx agentmods add skills/pku-yuangroup/openai4s/bio-data-visualization-sequence-logos
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add PKU-YuanGroup/OpenAI4S --skill bio-data-visualization-sequence-logos
Clone the repo
git clone --depth 1 https://github.com/PKU-YuanGroup/OpenAI4S

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bio-data-visualization-sequence-logos

README.md
[![agentmods](https://agentmods.dev/badge/skills/pku-yuangroup/openai4s/bio-data-visualization-sequence-logos/github.svg)](https://agentmods.dev/skills/pku-yuangroup/openai4s/bio-data-visualization-sequence-logos)
Your own site
<a href="https://agentmods.dev/skills/pku-yuangroup/openai4s/bio-data-visualization-sequence-logos"><img src="https://agentmods.dev/badge/skills/pku-yuangroup/openai4s/bio-data-visualization-sequence-logos/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for bio-data-visualization-sequence-logos

Your own site · 80×15
<a href="https://agentmods.dev/skills/pku-yuangroup/openai4s/bio-data-visualization-sequence-logos"><img src="https://agentmods.dev/badge/skills/pku-yuangroup/openai4s/bio-data-visualization-sequence-logos.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 88 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,390 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin 95% copy Near-identical to another mod in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00088 $0.03390
Opus 5 $0.00044 $0.01695
Sonnet 5 $0.00018 $0.00678
Haiku 4.5 $0.00009 $0.00339

Measured 9d ago against content hash 411a452b85e7, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-12, from the pricing page.

Security

Grade A, and why

bio-data-visualization-sequence-logos scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

This is a copy

95% identical to bio-data-visualization-sequence-logos — 12 lines differ, which has more behind it and is treated as the original. This page carries a canonical link to it rather than competing with it.

skills/bioskills/bio-data-visualization-sequence-logos/SKILL.md · 286 lines

How it starts

The opening of the file, as written. The whole thing — 286 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Version Compatibility

Reference examples tested with: ggseqlogo 0.2 (CRAN; per Wagih 2017), Logomaker 0.8+ (Python), WebLogo 3.7+ (CLI), Biopython 1.83+ (motif parsing), MEME suite 5.5+.

Before using code patterns, verify installed versions match. If versions differ:

  • Python: pip show <package> then help(module.function) to check signatures
  • R: packageVersion('<pkg>') then ?function_name

If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying.

Sequence Logos

"Plot a sequence motif" -> Render a per-position stack of letters whose total height encodes information content (Schneider-Stephens 1990 Nucleic Acids Res 18:6097) and individual letter height is proportional to base/aa frequency. The information-content encoding makes conserved positions visually tall and variable positions visually short — the visual is the conservation profile.

  • R: ggseqlogo::ggseqlogo (Wagih 2017 Bioinformatics 33:3645)
  • Python: logomaker.Logo
  • CLI: weblogo (Crooks 2004 Genome Res 14:1188)

The Single Most Important Modern Insight -- Bits vs Probability Are Different Visualizations

A sequence logo can encode each position as bits (information content) or probability (raw frequency). They look superficially similar; they communicate different things.

  • Bits (Schneider-Stephens 1990): position height = R = log2(K) − H(p) where K=4 for DNA, H is Shannon entropy. Maximum 2 bits for DNA, 4.3 bits for protein. A fully conserved position is 2 bits; a uniform position is 0. This is the canonical motif encoding.
  • Probability: position height = 1.0; letter height = frequency. Every position has the same total height. Cannot distinguish "conserved A" from "variable" — both can show 100% A at a position.
  • EDLogo (enrichment-depletion): Dey et al. 2018 — uses log-odds of observed vs background, supporting depleted-residue display.

Default to bits unless a specific reason exists otherwise. Bits is what reviewers expect to see for a TF binding site, splice site, or CRISPR spacer composition.

Read the full file on GitHub · 286 lines

Files

What ships with it

2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 286 lines · 88 tokens per session scan A 411a452b85e7

Subscribe to this mod's changes

bio-data-visualization-sequence-logos is a skill published in the GitHub repository PKU-YuanGroup/OpenAI4S (407 stars, last pushed yesterday), licensed MIT. It adds 88 tokens to every session and 3,390 once invoked, about $0.0004 per session on Opus 5. A static security scan graded it A with 0 findings. It is 95% identical to bio-data-visualization-sequence-logos, differing in 12 lines, and is treated as a copy.

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