Handles batch effects in bulk RNA-seq via design-matrix inclusion (the correct path for DE), ComBat/ComBat-seq for visualization, SVA for unknown latent factors, RUVSeq for negative-control-gene-anchored unwanted variation, and limma::removeBatchEffect for plotting only. Encodes the Nygaard 2016 cardinal sin against…
Use when someone asks what the SDLC Enterprise Framework (SEF) requires, which tier a repo is, what a stage or stage gate needs, how a gate script must behave, or where a rule lives in SEF — and before answering any SDLC question from memory. Routes each kind of question to the SEF file and section that answers it…
Help users add icons to their projects using the Unicon icon library. Unicon provides 19,000+ icons from Lucide, Phosphor, Hugeicons, Heroicons, Tabler, Feather, Remix, and Simple Icons. Use when adding icons to React, Vue, Svelte, or any web project; using the unicon CLI to search, get, or bundle icons; setting up…
Aggregate breadcrumbs, escalations, and audit logs from the last 14–30 days to surface recurring correction patterns that should be fixed at the source level (brief template, config/, WORKER-RULES.md) rather than re-fixed each session. Use during weekly maintenance Phase 2, after a redo dispatch, or when the operator…
EU AI Act compliance checking and risk classification. Automated compliance validation for high-risk AI systems with Article 11 technical documentation generation.
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