spatial-cnv

spatial-cnv is a skill for Claude Code, Codex from ShangBioLab/SpatialClaw. It costs 23 tokens per session (782 once invoked), scanned A, original, Apache-2.0.

A tool for estimating large chromosome-level gains and losses from spatial transcriptomics gene-expression data. These changes are called copy number variations, or CNVs, and can help distinguish abnormal from reference tissue patterns.

In plain words
What is it for?
Use it to infer and plot spatial CNVs from preprocessed AnnData .h5ad files with inferCNVpy.
Why use it?
It turns expression patterns into spatially mapped CNV scores, making it easier to see where possible chromosomal changes occur across a tissue section.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to infer and plot spatial CNVs from preprocessed AnnData .h5ad files with inferCNVpy.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/shangbiolab/spatialclaw/spatial-cnv
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add ShangBioLab/SpatialClaw --skill spatial-cnv
Clone the repo
git clone --depth 1 https://github.com/ShangBioLab/SpatialClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for spatial-cnv

README.md
[![agentmods](https://agentmods.dev/badge/skills/shangbiolab/spatialclaw/spatial-cnv/github.svg)](https://agentmods.dev/skills/shangbiolab/spatialclaw/spatial-cnv)
Your own site
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agentmods 80×15 button for spatial-cnv

Your own site · 80×15
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Per session 23 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 782 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00023 $0.00782
Opus 5.5 $0.00009 $0.00313
Sonnet 5.5 $0.00005 $0.00156
Haiku 4.5 $0.00002 $0.00078

Measured 1mo ago against content hash 0455ca416da2, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

spatial-cnv scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 1mo ago.

The scan reads SKILL.md. This mod also ships 2 executable files (spatial_cnv.py, tests/test_spatial_cnv.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/spatial/spatial-cnv/SKILL.md · 111 lines

How it starts

The opening of the file, as written. The whole thing — 111 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Spatial CNV

Spatial CNV infers large-scale chromosomal gains and losses from spatial transcriptomics expression patterns.

Core Capability

  1. inferCNVpy: Expression-based CNV inference using adata.X as log-normalized expression.
  2. Spatial CNV mapping: Overlay CNV scores on spatial coordinates.
  3. Reproducible reporting: Write report.md, result.json, processed AnnData, and figures.

Input

Format Extension Required Fields
AnnData .h5ad X log-normalized expression, gene positions in var; obsm["spatial"] for spatial plots

CLI

python skills/spatial/spatial-cnv/spatial_cnv.py \
  --input <preprocessed.h5ad> \
  --method infercnvpy \
  --reference-key cell_type \
  --reference-cat Normal \
  --output <dir>

python skills/spatial/spatial-cnv/spatial_cnv.py --demo --output <dir>
spatialclaw run spatial-cnv --input <file.h5ad> --output <dir>

Parameters

Parameter Default Description
--input - Preprocessed spatial .h5ad
--output required Output directory
--demo off Run built-in demo
--method infercnvpy CNV backend
--reference-key cell_type .obs column identifying reference categories
--reference-cat - One or more reference categories
--window-size 100 Genomic smoothing window size
--step 10 Genomic smoothing step

Method

inferCNVpy subtracts reference expression in log-space and smooths expression along ordered genomic windows. Genes must have chromosome/start/end annotations in adata.var.

Output

output_directory/
├── report.md
├── result.json
├── processed.h5ad
└── figures/
    ├── cnv_heatmap.png
    └── cnv_spatial.png

Dependencies

Required Python packages:

  • scanpy

Optional Python package:

  • infercnvpy

Safety

  • Local-first processing.
  • Reports include SPATIALCLAW disclaimers.
  • Parameters and outputs are recorded for reproducibility.

Read the full file on GitHub · 111 lines

Files

What ships with it

2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 1mo ago First seen · 111 lines · 23 tokens per session scan A 0455ca416da2

Subscribe to this mod's changes

spatial-cnv is a skill published in the GitHub repository ShangBioLab/SpatialClaw (11 stars, last pushed 4mo ago), licensed Apache-2.0. It adds 23 tokens to every session and 782 once invoked, about $0.0001 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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