spatial-cnv

spatial-cnv is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 93 tokens per session (1,271 once invoked), scanned A, original, Apache-2.0.

A workflow that estimates copy-number variation for spots in spatial transcriptomics data. Copy-number variation means that tumour cells have gained or lost sections of chromosomes compared with a normal reference.

In plain words
What is it for?
Use it to calculate per-spot copy-number scores, summarise genomic regions, and support tumour-versus-normal or clone deconvolution analyses.
Why use it?
It helps separate tumour and normal regions and can identify groups of spots with similar chromosome-level changes. An optional method also uses allele counts to improve clone analysis.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to calculate per-spot copy-number scores, summarise genomic regions, and support tumour-versus-normal or clone deconvolution analyses.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/spatial-cnv
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill spatial-cnv
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for spatial-cnv

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-cnv/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-cnv)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-cnv"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-cnv/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for spatial-cnv

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-cnv"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-cnv.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 93 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,271 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00093 $0.01271
Opus 5.5 $0.00037 $0.00508
Sonnet 5.5 $0.00019 $0.00254
Haiku 4.5 $0.00009 $0.00127

Measured 13d ago against content hash 19ef708ec06e, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

spatial-cnv scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 13d ago.

The scan reads SKILL.md. This mod also ships 5 executable files (_api.py, examples/example_step.py, spatial_cnv.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/spatial/spatial-cnv/SKILL.md · 119 lines

How it starts

The opening of the file, as written. The whole thing — 119 lines — stays where its author put it; the contents beside it link to each section on GitHub.

spatial-cnv

When to use

Infer expression-based CNV with infercnvpy, or allele-aware CNV with R Numbat. Gene coordinates and an appropriate diploid reference are needed for interpretation.

Use from a step

from skills._sdk.notebook import load_skill
library = load_skill("spatial-cnv")
library.cnv(adata, reference_key='cell_type', reference_cat=['Normal'])

Run examples/example_step.py with the step runner for a synthetic, executable example.

API

cnv(adata, *, method: str='infercnvpy', reference_key: str | None=None, reference_cat: list[str] | str | None=None, window_size: int=100, step: int=10, method_params: dict | None=None, random_state: int=0, allele_counts: pd.DataFrame | None=None)

Infer CNV in place from log-normalized X or Numbat raw counts.

infercnvpy needs var chromosome/start/end. Numbat needs layers['counts'], phased allele_counts and a diploid reference annotation. Counts and metadata are exchanged with R inside a temporary directory.

:param adata: AnnData with expression and method-specific annotations. :param method: infercnvpy (CLI default) or numbat. :param reference_key: Observation column marking reference cells; None uses all cells. :param reference_cat: Reference labels; None uses the backend's global reference. :param window_size: Genomic smoothing window, 100 genes by default. :param step: Sliding-window stride, 10 genes by default. :param method_params: CLI options with underscores, such as infercnv_n_jobs=1; None keeps defaults listed in references/parameters.md. :param random_state: infercnvpy PCA/graph/clustering and Numbat R seed, default 0. :param allele_counts: Numbat long-form DataFrame with cell/snp_id/CHROM/POS/AD/DP/GT/gene; None reads the legacy obsm['allele_counts'] table. Multiple SNPs per cell are allowed. :returns: The same AnnData with CNV matrices, scores and JSON diagnostics. :raises ValueError: Missing genomic annotations, raw counts or invalid parameters. :raises ImportError: Missing infercnvpy or R backend; use install_skill_deps.

Read the full file on GitHub · 119 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 13d ago Changed · -14 lines 19ef708ec06e
  2. 1mo ago First seen · 133 lines · 93 tokens per session scan A ada7cb51a38a

Subscribe to this mod's changes

spatial-cnv is a skill published in the GitHub repository TianGzlab/OmicsClaw (161 stars, last pushed 13d ago), licensed Apache-2.0. It adds 93 tokens to every session and 1,271 once invoked, about $0.0004 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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