spatial-sc2spatial

A Python API for transferring cell labels and gene-expression patterns from single-cell data to spatial transcriptomics data, which records gene activity together with a cell's location in tissue.

In plain words
What is it for?
Use it to transfer cell-type labels, map reference cells into tissue locations, fill in missing expression patterns, and create related embeddings with the supported mapping methods.
Why use it?
It helps interpret spatial data using an already annotated single-cell reference instead of analysing every spatial location without prior cell-type information.

Skill for Claude CodeCodex

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/shangbiolab/spatialclaw/spatial-sc2spatial
Any agent
npx skills add ShangBioLab/SpatialClaw --skill spatial-sc2spatial
Clone the repo
git clone --depth 1 https://github.com/ShangBioLab/SpatialClaw

Made for: Claude Code, Codex.

Per session 25 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 316 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. Scan, not verified.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5 $0.00025 $0.00316
Opus 5 $0.00013 $0.00158
Sonnet 5 $0.00005 $0.00063
Haiku 4.5 $0.00003 $0.00032

Measured 3d ago against content hash 41659f1dc5db, method: parsed. Prices are Anthropic first-party input rates as of 2026-08-30, from the pricing page.

Security

Grade A, and why

spatial-sc2spatial scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 3d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (spatial_sc2spatial.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/spatial/spatial-sc2spatial/SKILL.md · 50 lines

What it actually says

Spatial Reference Mapping

Spatial Reference Mapping transfers information from reference single-cell data to spatial transcriptomics datasets.

Interface

Python API only. This skill is intentionally not registered for spatialclaw run or other CLI execution routing.

Python API

from skills.spatial._lib.sc2spatial import run_sc2spatial_mapping

result = run_sc2spatial_mapping(adata_sp, adata_ref, method="label_transfer")

Capabilities

  • KNN label transfer from reference cell annotations.
  • Optional Tangram-style mapping.
  • Optional SpaGE/gimVI expression imputation and embedding helpers.
  • Optional CellTrek-style cell localization.

Validation

Covered by tests/spatial/test_library_only_skills.py::test_spatial_sc2spatial_smoke.

Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 3d ago First seen · 50 lines · 25 tokens per session scan A 41659f1dc5db

Subscribe to this mod's changes

spatial-sc2spatial is a skill published in the GitHub repository ShangBioLab/SpatialClaw (11 stars, last pushed 3mo ago), licensed Apache-2.0. It adds 25 tokens to every session and 316 once invoked, about $0.0001 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

Other skills, from other repositories

Gene Panel Selection Workflow

End-to-end workflow for gene panel design in scRNA-seq and spatial transcriptomics, that should be STRICTLY followed: dataset understanding + smart downsampling + train/test splits, algorithmic selection (HVG/DE/RF/scGeneFit/SpaPROS), optimal sub-panel discovery (ARI vs size), biological completion with a stability…

aristoteleo/PantheonOS · 110 tokens

Developmental Gene Panel Design Workflow

Panel design for DEVELOPING / dynamic systems (embryonic organs, differentiation, regeneration). The target experiment is usually a LATE / terminal stage, but the biology is a trajectory: terminal cell types are end-products of earlier lineage programs. A panel built from the target stage alone resolves terminal…

aristoteleo/PantheonOS · 129 tokens

Spatial Omics Skills Index

Skills for spatial transcriptomics analysis including single-cell to spatial mapping (MOSCOT), 3D visualization (PyVista), and related spatial workflows.

aristoteleo/PantheonOS · 37 tokens

jts

Use when performing precise 2D computational geometry in Java — spatial predicates (contains, intersects), overlay operations, buffering, triangulation. JTS (Java Topology Suite): the canonical geometry engine used as blueprint for GEOS, Shapely, and NetTopologySuite.

znlgis/opengis-skills · 58 tokens

geometry-api-java

Use when working with Esri geometry types (Point, Polyline, Polygon, Envelope) in Java — spatial operations, JSON/GeoJSON/WKT I/O, geodesic calculations. Esri Geometry API for Java.

znlgis/opengis-skills · 49 tokens

instrument-data-to-allotrope

Convert laboratory instrument output files (PDF, CSV, Excel, TXT) to Allotrope Simple Model (ASM) JSON format or flattened 2D CSV. Use this skill when scientists need to standardize instrument data for LIMS systems, data lakes, or downstream analysis. Supports auto-detection of instrument types. Outputs include full…

anthropics/knowledge-work-plugins · 123 tokens