spatial-deconv

spatial-deconv is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 84 tokens per session (2,149 once invoked), scanned A, original, Apache-2.0.

A spatial transcriptomics tool that estimates the mixture of cell types inside each Visium-style spot using a labelled single-cell RNA reference. A spot can contain several cells, so the result is a proportion for each cell type.

In plain words
What is it for?
Use it to estimate cell-type proportions per spot with methods including FlashDeconv, Cell2location, RCTD, DestVI, Stereoscope, Tangram, Spotlight, or CARD.
Why use it?
It helps interpret spot-level measurements when the technology does not measure one cell at a time.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to estimate cell-type proportions per spot with methods including FlashDeconv, Cell2location, RCTD, DestVI, Stereoscope, Tangram, Spotlight, or CARD.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/spatial-deconv
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill spatial-deconv
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for spatial-deconv

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-deconv/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-deconv)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-deconv"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-deconv/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for spatial-deconv

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-deconv"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-deconv.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 84 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 2,149 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00084 $0.02149
Opus 5 $0.00042 $0.01074
Sonnet 5 $0.00017 $0.00430
Haiku 4.5 $0.00008 $0.00215

Measured 6d ago against content hash dd4ae645dc13, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-09, from the pricing page.

Security

Grade A, and why

spatial-deconv scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 6d ago.

The scan reads SKILL.md. This mod also ships 2 executable files (spatial_deconv.py, tests/test_spatial_deconv.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/spatial/spatial-deconv/SKILL.md · 168 lines

How it starts

The opening of the file, as written. The whole thing — 168 lines — stays where its author put it; the contents beside it link to each section on GitHub.

spatial-deconv

When to use

The user has a Visium-style multi-cell-per-spot spatial AnnData PLUS a labelled scRNA reference AnnData and wants per-spot cell-type proportions. Eight backends:

  • flashdeconv (default) — ultra-fast O(N) CPU sketching. No GPU.
  • cell2location — Bayesian deep learning with spatial priors (--cell2location-n-epochs, --cell2location-detection-alpha, --cell2location-n-cells-per-spot). Requires scvi-tools + cell2location + torch.
  • rctd — Robust Cell Type Decomposition (R / spacexr).
  • destvi — multi-resolution VAE (--destvi-n-epochs, --destvi-n-hidden / --destvi-n-latent / --destvi-n-layers). Requires scvi-tools + torch.
  • stereoscope — two-stage probabilistic VAE (--stereoscope-learning-rate). Requires scvi-tools + torch.
  • tangram — gradient-based mapping (--tangram-n-epochs, --tangram-learning-rate). Requires tangram.
  • spotlight — NMF-based with marker-gene priors (--spotlight-n-top, --spotlight-min-prop, --spotlight-weight-id).
  • card — Conditional Autoregressive R-based deconvolution.

For single-cell-per-spot platforms (Xenium / MERFISH) use spatial-annotate. For tissue-region detection (no reference needed) use spatial-domains.

Inputs & Outputs

Inputs

  • File types: .h5ad
  • Requires a preprocessed AnnData (X normalised, PCA/neighbours present)
  • Expects obsm: spatial

Outputs

  • tables/card_proportions.csv
  • tables/card_refined_proportions.csv
  • tables/celltype_diversity.csv
  • tables/deconv_run_summary.csv
  • tables/deconv_spatial_points.csv
  • tables/deconv_spot_metrics.csv
  • tables/deconv_umap_points.csv
  • tables/dominant_celltype.csv
  • tables/dominant_celltype_counts.csv
  • tables/mean_proportions.csv
  • tables/proportions.csv
  • tables/rctd_proportions.csv
  • tables/ref_celltypes.csv
  • tables/ref_counts.csv
  • tables/ref_meta.csv
  • tables/spatial_coords.csv
  • tables/spatial_counts.csv
  • tables/spotlight_proportions.csv
  • figures/assignment_margin_distribution.png
  • figures/assignment_margin_spatial.png
  • figures/celltype_diversity.png
  • figures/dominant_celltype.png
  • figures/dominant_celltype_distribution.png
  • figures/mean_proportions.png
  • figures/spatial_proportions.png
  • figures/umap_proportions.png
  • processed.h5ad
  • report.md
  • result.json
  • Processed AnnData (saves_h5ad) — adds obs: deconv_{method}_dominant_cell_type, deconv_{method}_dominant_proportion; obsm: deconvolution_{method}

Read the full file on GitHub · 168 lines

Files

What ships with it

8 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 6d ago First seen · 168 lines · 84 tokens per session scan A dd4ae645dc13

Subscribe to this mod's changes

spatial-deconv is a skill published in the GitHub repository TianGzlab/OmicsClaw (160 stars, last pushed 1mo ago), licensed Apache-2.0. It adds 84 tokens to every session and 2,149 once invoked, about $0.0004 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

Related

Other skills, from other repositories

spatial-deconvolution

Cell-type deconvolution for spatial transcriptomics by mapping a single-cell RNA-seq reference onto spatial data.

ShangBioLab/SpatialClaw · 28 tokens

spatial-cell-annotation

Cell type annotation for spatial transcriptomics data using marker-based scoring, Tangram mapping, scANVI transfer, or CellAssign probabilistic models.

ShangBioLab/SpatialClaw · 35 tokens

spatial-sc2spatial

Python API skill for mapping reference single-cell annotations and expression programs onto spatial transcriptomics data.

ShangBioLab/SpatialClaw · 25 tokens

pkpd-modeling

Pharmacokinetic and pharmacodynamic modelling and simulation - non-compartmental analysis, compartmental and population PK, PK/PD and exposure-response, TMDD, PBPK orientation, bioequivalence, allometric scaling and first-in-human dose, drug interaction prediction, and Bayesian therapeutic drug monitoring. Use when…

K-Dense-AI/scientific-agent-skills · 273 tokens

neuropixels-analysis

Analyze Neuropixels extracellular recordings end-to-end with SpikeInterface. Covers loading SpikeGLX/Open Ephys/NWB data, preprocessing, drift/motion correction, Kilosort4 (and CPU) spike sorting, quality metrics, and unit curation (threshold-based, model-based UnitRefine, and AI-assisted visual review). Use when…

K-Dense-AI/scientific-agent-skills · 98 tokens

onekgpd

Query the 1000 Genomes Project dataset (3,202 whole-genome-sequenced individuals, GRCh38) at the level of individual participants. Use when a question is about individuals or variants in the 1000 Genomes Project cohort: which individuals carry variants matching specific criteria in a gene or region, which individuals…

K-Dense-AI/scientific-agent-skills · 143 tokens