spatial-deconv

spatial-deconv is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 84 tokens per session (1,384 once invoked), scanned A, original, Apache-2.0.

A spatial transcriptomics tool that estimates the mixture of cell types inside each Visium-style spot using a labelled single-cell RNA reference. A spot can contain several cells, so the result is a proportion for each cell type.

In plain words
What is it for?
Use it to estimate cell-type proportions per spot with methods including FlashDeconv, Cell2location, RCTD, DestVI, Stereoscope, Tangram, Spotlight, or CARD.
Why use it?
It helps interpret spot-level measurements when the technology does not measure one cell at a time.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to estimate cell-type proportions per spot with methods including FlashDeconv, Cell2location, RCTD, DestVI, Stereoscope, Tangram, Spotlight, or CARD.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/spatial-deconv
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill spatial-deconv
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for spatial-deconv

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-deconv/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-deconv)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-deconv"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-deconv/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for spatial-deconv

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-deconv"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-deconv.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 84 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,384 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00084 $0.01384
Opus 5.5 $0.00034 $0.00554
Sonnet 5.5 $0.00017 $0.00277
Haiku 4.5 $0.00008 $0.00138

Measured 17d ago against content hash db63f1bff7d1, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

spatial-deconv scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 17d ago.

The scan reads SKILL.md. This mod also ships 5 executable files (_api.py, examples/example_step.py, spatial_deconv.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/spatial/spatial-deconv/SKILL.md · 138 lines

How it starts

The opening of the file, as written. The whole thing — 138 lines — stays where its author put it; the contents beside it link to each section on GitHub.

spatial-deconv

When to use

Estimate cell-type proportions for spatial spots using a labelled single-cell reference. Use spatial-annotate for discrete labels and spatial-domains for tissue regions. Every method requires a reference; the CLI default is cell2location.

Use from a step

from skills._sdk.notebook import load_skill, read_input, write_output
spatial = read_input("spatial.h5ad")
reference = read_input("reference.h5ad")
library = load_skill("spatial-deconv")
library.deconvolve(spatial, reference=reference, method="flashdeconv", random_state=0)
write_output(library.proportions(spatial), "tables/proportions.csv")

examples/example_step.py uses an explicit synthetic reference and verifies known stripe identities; it is not a real-tissue benchmark. It sets lambda_spatial=10 for the small grid; the CLI default remains 5000.

API

deconvolve(adata, *, reference, method: str='cell2location', cell_type_key: str='cell_type', random_state: int=0, **parameters)

Estimate proportions in place and return the same spatial AnnData.

Count models read layers['counts'], raw or X in that order. FlashDeconv, Tangram and SPOTlight read nonnegative X. Reference data are copied. RCTD, SPOTlight and CARD retain their temporary R bridges; their wrappers do not expose a seed and results vary between runs.

:param adata: Spatial AnnData; input expression is retained. :param reference: Required labelled reference AnnData; load it with read_input. :param method: CLI default cell2location; flashdeconv, rctd, destvi, stereoscope, tangram, spotlight and card are also supported. :param cell_type_key: Reference label column, CLI default cell_type. :param random_state: Seed for FlashDeconv/Tangram and scvi training, default 0. :param parameters: Method options in references/parameters.md, with CLI prefixes removed; omitted options keep their CLI defaults. :returns: The same AnnData with deconvolution_, labels and JSON diagnostics. :raises ValueError: Invalid method, expression, reference labels or backend proportions. :raises TypeError: Reference is not AnnData or a method option is unknown. :raises ImportError: A backend is missing; use install_skill_deps for its named package.

Read the full file on GitHub · 138 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 17d ago Changed · -30 lines db63f1bff7d1
  2. 1mo ago First seen · 168 lines · 84 tokens per session scan A dd4ae645dc13

Subscribe to this mod's changes

spatial-deconv is a skill published in the GitHub repository TianGzlab/OmicsClaw (161 stars, last pushed 17d ago), licensed Apache-2.0. It adds 84 tokens to every session and 1,384 once invoked, about $0.0003 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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