bulkrna-coexpression

bulkrna-coexpression is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 60 tokens per session (1,211 once invoked), scanned A, original, Apache-2.0.

A bulk RNA-seq analysis that groups genes with similar activity across samples into co-expression modules and identifies central hub genes. Bulk RNA-seq measures average gene activity across a mixed sample rather than individual cells.

In plain words
What is it for?
Use it on a cohort of bulk RNA-seq samples to find gene modules, hub genes, module-to-trait relationships, and supporting plots.
Why use it?
Looking at genes one at a time can hide groups that change together. The analysis reveals coordinated gene programs and how those groups relate to sample traits.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it on a cohort of bulk RNA-seq samples to find gene modules, hub genes, module-to-trait relationships, and supporting plots.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/bulkrna-coexpression
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill bulkrna-coexpression
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bulkrna-coexpression

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-coexpression/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-coexpression)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-coexpression"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-coexpression/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for bulkrna-coexpression

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-coexpression"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-coexpression.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 60 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,211 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00060 $0.01211
Opus 5.5 $0.00024 $0.00484
Sonnet 5.5 $0.00012 $0.00242
Haiku 4.5 $0.00006 $0.00121

Measured 14d ago against content hash bc6e42311cb5, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

bulkrna-coexpression scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 14d ago.

The scan reads SKILL.md. This mod also ships 6 executable files (_api.py, bulkrna_coexpression.py, examples/example_step.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/bulkrna/bulkrna-coexpression/SKILL.md · 134 lines

How it starts

The opening of the file, as written. The whole thing — 134 lines — stays where its author put it; the contents beside it link to each section on GitHub.

bulkrna-coexpression

When to use

Load when discovering bulk gene co-expression modules and hub genes with R WGCNA. Skip direct expression contrasts (use bulkrna-de), existing-gene-list PPI lookup (use bulkrna-ppi-network), or single-cell networks (use sc-grn).

Use from a step

from skills._sdk.notebook import load_skill, write_output
library = load_skill("bulkrna-coexpression")
result = library.analyze(data, power=6, min_module_size=10)
write_output(result, "tables/result.csv")
write_output(library.module_sizes_figure(result), "figures/result.png")

Read expression and metadata with read_input before calling the library. examples/example_step.py constructs a small synthetic dataset and checks its results through the step runner and fresh-kernel replay.

API

analyze(data: pd.DataFrame, *, power: int | None=None, min_module_size: int=10, random_state: int=54321) -> pd.DataFrame

Return R WGCNA gene-module assignments, leaving expression unchanged.

:param data: Nonnegative feature-by-sample expression; provide normalized data on the intended correlation scale. :param power: CLI default None selects the soft threshold; set a positive integer to override it. :param min_module_size: CLI default 10 genes per module. :param random_state: WGCNA blockwiseModules default seed 54321; fixes its preclustering. :returns: Gene/module DataFrame with diagnostics, hub genes and threshold fit in attrs. :raises ValueError: Input, sample count, power or module size is invalid. :raises ImportError: R WGCNA or Matrix is unavailable. :raises RuntimeError: R analysis fails.

run_info(data: pd.DataFrame, *, keep: bool=True) -> dict

Return WGCNA method diagnostics and summary.

:param data: Result from analyze. :param keep: Keep diagnostics by default; the CLI passes False. :returns: Independent diagnostics dictionary. :raises ValueError: No WGCNA diagnostics are present.

Read the full file on GitHub · 134 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 14d ago Changed · +42 lines · -13 tokens per session bc6e42311cb5
  2. 1mo ago First seen · 92 lines · 73 tokens per session scan A 96394e8417ec

Subscribe to this mod's changes

bulkrna-coexpression is a skill published in the GitHub repository TianGzlab/OmicsClaw (161 stars, last pushed 14d ago), licensed Apache-2.0. It adds 60 tokens to every session and 1,211 once invoked, about $0.0002 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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