bulkrna-enrichment

bulkrna-enrichment is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 59 tokens per session (811 once invoked), scanned A, original, Apache-2.0.

A workflow for finding biological pathways that are overrepresented in a list of genes from bulk RNA sequencing. Bulk RNA sequencing measures average gene activity across a sample, and pathway enrichment checks whether related genes appear unusually often.

In plain words
What is it for?
Use it after comparing two bulk RNA-seq conditions, with either a filtered gene list or a ranked full list, to produce enrichment tables, plots, and a report.
Why use it?
It turns a long list of changed genes into groups of biological processes that may help explain the result.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it after comparing two bulk RNA-seq conditions, with either a filtered gene list or a ranked full list, to produce enrichment tables, plots, and a report.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/bulkrna-enrichment
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill bulkrna-enrichment
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bulkrna-enrichment

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-enrichment/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-enrichment)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-enrichment"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-enrichment/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for bulkrna-enrichment

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-enrichment"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-enrichment.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 59 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 811 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00059 $0.00811
Opus 5.5 $0.00024 $0.00324
Sonnet 5.5 $0.00012 $0.00162
Haiku 4.5 $0.00006 $0.00081

Measured 19d ago against content hash 013ac0b8cabe, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

bulkrna-enrichment scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 19d ago.

The scan reads SKILL.md. This mod also ships 7 executable files (_api.py, bulkrna_enrichment.py, examples/example_step.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/bulkrna/bulkrna-enrichment/SKILL.md · 80 lines

How it starts

The opening of the file, as written. The whole thing — 80 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Bulk pathway enrichment

Purpose

Test differential-expression results against explicit pathway gene sets. ORA uses the union of those sets as its background; GSEA ranks all input genes. Gene identifiers must use the same namespace. R adapters are not implemented.

Inputs & Outputs

CLI input is a CSV with gene, log2FoldChange, pvalue, padj; --gene-set-file is a JSON mapping from pathway names to gene lists. The library accepts the table and mapping directly. CLI writes tables/enrichment_results.csv, tables/enrichment_significant.csv, report/result files and method-dependent figures.

API

enrich(de_results, *, gene_sets, method='ora', padj_cutoff=0.05, lfc_cutoff=1.0, random_state=42)

Test pathway enrichment without choosing a reference database.

:param de_results: DataFrame with gene, log2FoldChange, pvalue and padj. :param gene_sets: Nonempty mapping from pathway names to unique gene lists. :param method: CLI default ora; gsea runs GSEApy prerank. :param padj_cutoff: CLI significance threshold, default 0.05. :param lfc_cutoff: Strict absolute fold-change threshold, default 1.0. :param random_state: Local permutation seed, legacy default 42. :returns: Enrichment DataFrame with execution diagnostics in attrs. :raises ValueError: Missing reference, invalid values or unsupported method.

run_info(result, *, keep=True)

Read tested terms, pathway universe and requested/executed methods.

:param result: DataFrame returned by enrich. :param keep: Default True; False removes diagnostic attrs. :returns: Diagnostic dictionary; empty after removal.

enrichment_figure(result)

Plot pathway adjusted significance without saving it.

:param result: Enrichment DataFrame with term and padj columns. :returns: matplotlib Figure. :raises KeyError: Required columns are missing.

Key CLI

python skills/bulkrna/bulkrna-enrichment/bulkrna_enrichment.py --demo --output /tmp/bulkrna-enrichment
python skills/bulkrna/bulkrna-enrichment/bulkrna_enrichment.py --input de.csv --gene-set-file pathways.json --output results/enrichment --method ora

Read the full file on GitHub · 80 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 19d ago Changed · -9 lines 013ac0b8cabe
  2. 1mo ago First seen · 89 lines · 59 tokens per session scan A 9b53ed45e862

Subscribe to this mod's changes

bulkrna-enrichment is a skill published in the GitHub repository TianGzlab/OmicsClaw (161 stars, last pushed 20d ago), licensed Apache-2.0. It adds 59 tokens to every session and 811 once invoked, about $0.0002 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

Other skills, from other repositories

enrichment

Functional enrichment and pathway analysis including GSEA, ORA, ssGSEA, GSVA, and decoupler-based activity inference.

inflexa-ai/inflexa · 29 tokens

spatial-enrichment

Pathway and gene set enrichment analysis for spatial transcriptomics data.

ShangBioLab/SpatialClaw · 18 tokens

kegg-query

Query KEGG database for drug information, pathway analysis, and disease-drug-target discovery. Use this skill when: (1) Looking up drug information including efficacy, targets, metabolism, and interactions, (2) Analyzing metabolic or signaling pathways to retrieve genes, compounds, and modules, (3) Discovering…

PharMolix/OpenBioMed · 82 tokens

neuropixels-analysis

Analyzes Neuropixels extracellular recordings end-to-end with SpikeInterface. Covers loading SpikeGLX/Open Ephys/NWB data, preprocessing, drift/motion correction, Kilosort4 (and CPU) spike sorting, quality metrics, and unit curation (threshold-based, model-based UnitRefine, and AI-assisted visual review). Use when…

K-Dense-AI/scientific-agent-skills · 99 tokens

onekgpd

Queries the 1000 Genomes Project dataset (3,202 whole-genome-sequenced individuals, GRCh38) at the level of individual participants. Use when a question is about individuals or variants in the 1000 Genomes Project cohort: which individuals carry variants matching specific criteria in a gene or region, which…

K-Dense-AI/scientific-agent-skills · 143 tokens

pkpd-modeling

Pharmacokinetic and pharmacodynamic modelling and simulation - non-compartmental analysis, compartmental and population PK, PK/PD and exposure-response, TMDD, PBPK orientation, bioequivalence, allometric scaling and first-in-human dose, drug interaction prediction, and Bayesian therapeutic drug monitoring. Use when…

K-Dense-AI/scientific-agent-skills · 273 tokens