proteomics-de

proteomics-de is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 79 tokens per session (1,114 once invoked), scanned A, original, Apache-2.0.

A tool for comparing protein abundance between two sample groups in a wide protein-by-sample CSV. It calculates fold changes, statistical test results, and adjusted false-discovery values.

In plain words
What is it for?
Use it for pairwise differential protein-abundance analysis with a t-test, Welch's t-test, or Mann–Whitney test.
Why use it?
It identifies proteins that differ between two conditions and reduces the manual work of running tests and filtering significant results.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it for pairwise differential protein-abundance analysis with a t-test, Welch's t-test, or Mann–Whitney test.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/proteomics-de
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill proteomics-de
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for proteomics-de

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/proteomics-de/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/proteomics-de)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/proteomics-de"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/proteomics-de/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for proteomics-de

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/proteomics-de"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/proteomics-de.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 79 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,114 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00079 $0.01114
Opus 5.5 $0.00032 $0.00446
Sonnet 5.5 $0.00016 $0.00223
Haiku 4.5 $0.00008 $0.00111

Measured 20d ago against content hash 4d275066c2df, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

proteomics-de scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 20d ago.

The scan reads SKILL.md. This mod also ships 4 executable files (_api.py, examples/example_step.py, proteomics_de.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/proteomics/proteomics-de/SKILL.md · 133 lines

How it starts

The opening of the file, as written. The whole thing — 133 lines — stays where its author put it; the contents beside it link to each section on GitHub.

proteomics-de

When to use

ttest is the CLI default; welch and mann_whitney are alternatives. Groups default to the first and second half of columns. Use existing search-engine tables; this skill does not search raw spectra.

Use from a step

from skills._sdk.notebook import load_skill, write_output
library = load_skill('proteomics-de')
data = library.demo_data(random_state=42)
result = library.differential_abundance(data)
write_output(result, 'tables/differential_abundance.csv')

For real data, use read_input and pass any read_table helper as reader=. The executable examples/example_step.py also checks the result and writes a Figure.

API

differential_abundance(data: pd.DataFrame, *, group1: list | None=None, group2: list | None=None, method: str='ttest') -> pd.DataFrame

Compare groups and return a new table with group2-minus-group1 log2 fold changes.

:param data: Protein-indexed, sample-column linear intensities; nonpositive values are missing. :param group1: First group columns; None uses the first half as in the CLI. :param group2: Second group columns; None uses the second half as in the CLI. :param method: CLI default ttest; welch uses unequal variance and mann_whitney tests ranks. :returns: Per-protein statistics and BH-adjusted p values. :raises ValueError: Groups overlap, are empty, or the protein index is not unique.

significant(results: pd.DataFrame, *, alpha: float=0.05, log2fc_threshold: float=0.0) -> pd.DataFrame

Select significant proteins from an existing comparison.

:param results: Differential abundance results with padj and log2fc. :param alpha: CLI default 0.05; strict upper bound on BH-adjusted p values. :param log2fc_threshold: CLI default 0 disables the absolute fold-change filter. :returns: A new table retaining selected rows. :raises ValueError: Thresholds are outside their allowed ranges.

run_info(table: pd.DataFrame, *, keep: bool=True) -> dict

Read the full file on GitHub · 133 lines

Files

What ships with it

7 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 20d ago Changed · +30 lines 4d275066c2df
  2. 1mo ago First seen · 103 lines · 79 tokens per session scan A 7cc16bdc5cc4

Subscribe to this mod's changes

proteomics-de is a skill published in the GitHub repository TianGzlab/OmicsClaw (161 stars, last pushed 20d ago), licensed Apache-2.0. It adds 79 tokens to every session and 1,114 once invoked, about $0.0003 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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