qiime2-16s-microbiome

qiime2-16s-microbiome is a skill for Claude Code, Codex from YuliaNuzhnenko/bioinformatics-agent-skills. It costs 48 tokens per session (478 once invoked), scanned A, original, MIT.

A QIIME 2 workflow for analyzing 16S microbiome sequencing data. It identifies sequence variants, measures differences within and between samples, assigns taxonomy using SILVA, and creates three-dimensional PCoA plots.

In plain words
What is it for?
Use it to dereplicate amplicon sequences with DADA2, calculate alpha and beta diversity, classify organisms, and generate result tables plus SVG or PNG figures.
Why use it?
It combines common microbiome analysis steps so raw or processed sequencing results can be turned into comparable summaries and visualizations.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to dereplicate amplicon sequences with DADA2, calculate alpha and beta diversity, classify organisms, and generate result tables plus SVG or PNG figures.

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Install with agentmods
npx agentmods add skills/yulianuzhnenko/bioinformatics-agent-skills/qiime2-16s-microbiome
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add YuliaNuzhnenko/bioinformatics-agent-skills --skill qiime2-16s-microbiome
Clone the repo
git clone --depth 1 https://github.com/YuliaNuzhnenko/bioinformatics-agent-skills

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for qiime2-16s-microbiome

README.md
[![agentmods](https://agentmods.dev/badge/skills/yulianuzhnenko/bioinformatics-agent-skills/qiime2-16s-microbiome/github.svg)](https://agentmods.dev/skills/yulianuzhnenko/bioinformatics-agent-skills/qiime2-16s-microbiome)
Your own site
<a href="https://agentmods.dev/skills/yulianuzhnenko/bioinformatics-agent-skills/qiime2-16s-microbiome"><img src="https://agentmods.dev/badge/skills/yulianuzhnenko/bioinformatics-agent-skills/qiime2-16s-microbiome/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for qiime2-16s-microbiome

Your own site · 80×15
<a href="https://agentmods.dev/skills/yulianuzhnenko/bioinformatics-agent-skills/qiime2-16s-microbiome"><img src="https://agentmods.dev/badge/skills/yulianuzhnenko/bioinformatics-agent-skills/qiime2-16s-microbiome.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 48 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 478 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00048 $0.00478
Opus 5.5 $0.00019 $0.00191
Sonnet 5.5 $0.00010 $0.00096
Haiku 4.5 $0.00005 $0.00048

Measured 1mo ago against content hash f2e02da20022, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

qiime2-16s-microbiome scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 1mo ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/qiime2-16s-microbiome/SKILL.md · 55 lines

What it actually says

Agent Skill: QIIME2 16S Microbiome & Dysbiosis Skill

Domain Version

📌 Description

DADA2 amplicon sequence variant (ASV) dereplication, Alpha/Beta diversity index calculation, SILVA taxonomy classification, and 3D PCoA projections.


🤖 Agent Execution Protocol

When an AI Agent is tasked with qiime2-16s-microbiome:

  1. Input Validation: Verify that the required input files or coordinates are supplied.
  2. Environment Check: Ensure dependencies (QIIME2, DADA2, scikit-bio, phyloseq) are installed.
  3. Execution: Run the protocol pipeline snippet below.
  4. Output Generation: Produce actionable Markdown/JSON summaries with publication figures.

💻 Protocol Code Snippet

# QIIME2 Diversity Protocol
qiime diversity core-metrics-phylogenetic --i-phylogeny tree.qza --i-table table.qza --p-sampling-depth 10000 --output-dir core-metrics-results


📥 Input & Output Specifications

Input Contract

  • Target Files: Valid input data matching domain formats.
  • Parameters: Quality thresholds and cutoffs.

Output Contract

  • Results Table: Structured summary dataframe or matrix.
  • Visualization: Rendered SVG/PNG figures.

📄 License

Distributed under the MIT License. See LICENSE for details.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 1mo ago First seen · 55 lines · 48 tokens per session scan A f2e02da20022

Subscribe to this mod's changes

qiime2-16s-microbiome is a skill published in the GitHub repository YuliaNuzhnenko/bioinformatics-agent-skills (10 stars, last pushed 2mo ago), licensed MIT. It adds 48 tokens to every session and 478 once invoked, about $0.0002 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-31.

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