bio-clinical-databases-acmg-classification

bio-clinical-databases-acmg-classification is a skill for Claude Code, Codex from FridrichMethod/awesome-skills. It costs 167 tokens per session (7,988 once invoked), scanned A, original, no licence file.

A clinical-variant classification skill that applies published ACMG/AMP and ClinGen methods to assess whether genetic variants may be disease-related.

In plain words
What is it for?
Use it when evaluating genetic variants with evidence from population data, protein-impact predictions, splicing predictions, functional tests, and related clinical databases.
Why use it?
It brings several evidence rules, prediction models, and calibrated thresholds into the classification process instead of leaving those decisions unspecified.

Skill for Claude CodeCodex

Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

agentmods
npx agentmods add skills/fridrichmethod/awesome-skills/acmg-classification
Any agent
npx skills add FridrichMethod/awesome-skills --skill acmg-classification
Clone the repo
git clone --depth 1 https://github.com/FridrichMethod/awesome-skills

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bio-clinical-databases-acmg-classification

README.md
[![agentmods](https://agentmods.dev/badge/skills/fridrichmethod/awesome-skills/acmg-classification.svg)](https://agentmods.dev/skills/fridrichmethod/awesome-skills/acmg-classification)
Your own site
<a href="https://agentmods.dev/skills/fridrichmethod/awesome-skills/acmg-classification"><img src="https://agentmods.dev/badge/skills/fridrichmethod/awesome-skills/acmg-classification.svg" alt="Measured on agentmods" height="20"></a>
Per session 167 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 7,988 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 1 finding. Scan, not verified.
Origin unknown No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5 $0.00167 $0.07988
Opus 5 $0.00084 $0.03994
Sonnet 5 $0.00033 $0.01598
Haiku 4.5 $0.00017 $0.00799

Measured 5d ago against content hash 398ed0fd765f, method: parsed. Prices are Anthropic first-party input rates as of 2026-08-30, from the pricing page.

Security

Grade A, and why

bio-clinical-databases-acmg-classification scanned grade A with 1 finding against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 5d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (examples/acmg_classify.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Makes network callslowCapability

Not a fault in itself. Listed so you know the mod talks to something, and to what.

r = requests.get(f'https://api.genebe.net/cloud/api-public/v1/variant',
skills/acmg-classification/SKILL.md · 468 lines

The source is not reproduced here

A licence we could not identify

The repository carries a LICENSE file, but it is custom or dual enough that GitHub cannot name it and neither can this catalogue. Unknown terms are not permission, so the body is not copied here. Read the licence at the source and decide for yourself.

Read it on GitHub

Files

What ships with it

2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 5d ago First seen · 468 lines · 167 tokens per session scan A 398ed0fd765f

Subscribe to this mod's changes

bio-clinical-databases-acmg-classification is a skill published in the GitHub repository FridrichMethod/awesome-skills (14 stars, last pushed 5d ago), with no licence file. It adds 167 tokens to every session and 7,988 once invoked, about $0.0008 per session on Opus 5. A static security scan graded it A with 1 finding (makes network calls). No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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