deepchem-circular-featurization

deepchem-circular-featurization is a skill for Claude Code, Codex from ma-compbio-lab/SkillFoundry. It costs 49 tokens per session (568 once invoked), scanned A, original, Apache-2.0.

A small tool for turning SMILES strings—a text notation for chemical structures—into DeepChem circular fingerprints. These fingerprints represent local molecular patterns as fixed-length bit vectors.

In plain words
What is it for?
Use it to fingerprint a small set of molecules, obtain canonical SMILES and active bit positions, and prepare inputs for later molecular machine-learning work.
Why use it?
It provides a deterministic, lightweight molecular representation without requiring the heavier machine-learning frameworks used for training models.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to fingerprint a small set of molecules, obtain canonical SMILES and active bit positions, and prepare inputs for later molecular machine-learning work.

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Install with agentmods
npx agentmods add skills/ma-compbio-lab/skillfoundry/deepchem-circular-featurization
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add ma-compbio-lab/SkillFoundry --skill deepchem-circular-featurization
Clone the repo
git clone --depth 1 https://github.com/ma-compbio-lab/SkillFoundry

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for deepchem-circular-featurization

README.md
[![agentmods](https://agentmods.dev/badge/skills/ma-compbio-lab/skillfoundry/deepchem-circular-featurization/github.svg)](https://agentmods.dev/skills/ma-compbio-lab/skillfoundry/deepchem-circular-featurization)
Your own site
<a href="https://agentmods.dev/skills/ma-compbio-lab/skillfoundry/deepchem-circular-featurization"><img src="https://agentmods.dev/badge/skills/ma-compbio-lab/skillfoundry/deepchem-circular-featurization/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for deepchem-circular-featurization

Your own site · 80×15
<a href="https://agentmods.dev/skills/ma-compbio-lab/skillfoundry/deepchem-circular-featurization"><img src="https://agentmods.dev/badge/skills/ma-compbio-lab/skillfoundry/deepchem-circular-featurization.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 49 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 568 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00049 $0.00568
Opus 5 $0.00024 $0.00284
Sonnet 5 $0.00010 $0.00114
Haiku 4.5 $0.00005 $0.00057

Measured 9d ago against content hash 9d6c16f62e8e, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-08, from the pricing page.

Security

Grade A, and why

deepchem-circular-featurization scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

The scan reads SKILL.md. This mod also ships 2 executable files (scripts/compute_circular_fingerprints.py, tests/test_deepchem_circular_featurization.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/drug-discovery-and-cheminformatics/deepchem-circular-featurization/SKILL.md · 53 lines

How it starts

The opening of the file, as written. The whole thing — 53 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Purpose

Turn one or more SMILES strings into deterministic DeepChem CircularFingerprint summaries without requiring TensorFlow or PyTorch.

When to use

  • You need a lightweight DeepChem-backed fingerprinting step before downstream molecular ML work.
  • You want a compact JSON payload with canonical SMILES, dense bit vectors, and active bit indices.

When not to use

  • You need graph featurizers, model training, or dataset download workflows.
  • You need batch-scale featurization for very large libraries.

Inputs

  • Repeated --smiles arguments, or no arguments to use the bundled aspirin/caffeine example
  • Optional --size, --radius, and --out

Outputs

  • JSON summary with canonical_smiles, bit_vector, on_bits, and on_bit_count for each molecule

Requirements

  • slurm/envs/deepchem
  • DeepChem 2.8.0 and RDKit installed in that prefix

Procedure

  1. Run slurm/envs/deepchem/bin/python skills/drug-discovery-and-cheminformatics/deepchem-circular-featurization/scripts/compute_circular_fingerprints.py --out skills/drug-discovery-and-cheminformatics/deepchem-circular-featurization/assets/aspirin_caffeine_fingerprints.json.
  2. Inspect size, radius, and each molecule's canonical_smiles, bit_vector, and on_bits.
  3. Reuse the compact JSON as a deterministic preprocessing artifact for later experiments.

Validation

  • The command exits successfully under slurm/envs/deepchem/bin/python.
  • Each molecule gets a non-empty canonical SMILES and a bit vector of the requested length.
  • Repeated runs with the same inputs produce the same fingerprint payload.

Failure modes and fixes

  • Missing DeepChem runtime: run the script with slurm/envs/deepchem/bin/python.
  • Invalid SMILES: correct the input string before featurization.
  • Optional backend warnings: TensorFlow and PyTorch are not required for this fingerprint-only skill.

Safety and limits

  • Local featurization only.
  • No activity prediction, medicinal-chemistry recommendation, or safety interpretation is implied.

Read the full file on GitHub · 53 lines

Files

What ships with it

8 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 53 lines · 49 tokens per session scan A 9d6c16f62e8e

Subscribe to this mod's changes

deepchem-circular-featurization is a skill published in the GitHub repository ma-compbio-lab/SkillFoundry (38 stars, last pushed 4mo ago), licensed Apache-2.0. It adds 49 tokens to every session and 568 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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