gwas-starter

gwas-starter is a skill for Claude Code, Codex from ma-compbio-lab/SkillFoundry. It costs 0 tokens per session (397 once invoked), scanned A, original, Apache-2.0.

A quality-checking workflow for GWAS summary statistics, the results tables from studies that test genetic variants for links with traits. It standardizes common fields, flags problems, and writes a report for follow-up analysis.

In plain words
What is it for?
Use it to prepare summary-statistics tables for clumping, heritability analysis, fine-mapping, polygenic risk scoring, or functional follow-up.
Why use it?
It catches malformed data, duplicates, low-information variants, and ambiguous DNA-letter combinations before later genetic analyses rely on them.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to prepare summary-statistics tables for clumping, heritability analysis, fine-mapping, polygenic risk scoring, or functional follow-up.

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Install with agentmods
npx agentmods add skills/ma-compbio-lab/skillfoundry/gwas-starter
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add ma-compbio-lab/SkillFoundry --skill gwas-starter
Clone the repo
git clone --depth 1 https://github.com/ma-compbio-lab/SkillFoundry

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for gwas-starter

README.md
[![agentmods](https://agentmods.dev/badge/skills/ma-compbio-lab/skillfoundry/gwas-starter.svg)](https://agentmods.dev/skills/ma-compbio-lab/skillfoundry/gwas-starter)
Your own site
<a href="https://agentmods.dev/skills/ma-compbio-lab/skillfoundry/gwas-starter"><img src="https://agentmods.dev/badge/skills/ma-compbio-lab/skillfoundry/gwas-starter.svg" alt="Measured on agentmods" height="20"></a>
Per session 0 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 397 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00000 $0.00397
Opus 5 $0.00000 $0.00198
Sonnet 5 $0.00000 $0.00079
Haiku 4.5 $0.00000 $0.00040

Measured 4d ago against content hash 9663ed6ae7fc, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-07, from the pricing page.

Security

Grade A, and why

gwas-starter scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 4d ago.

The scan reads SKILL.md. This mod also ships 3 executable files (scripts/run_frontier_starter.py, scripts/run_gwas_summary_qc.py, tests/test_gwas_starter.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/genomics/gwas-starter/SKILL.md · 33 lines

What it actually says

GWAS Summary Statistics QC Starter

Use this skill to run a deterministic local pass over GWAS summary statistics, flag common QC issues, and emit a compact interpretation plan for downstream clumping, heritability, and functional follow-up.

What This Skill Does

  • reads a GWAS summary-statistics table with common header aliases
  • standardizes core fields such as chromosome, position, alleles, effect size, p-value, sample size, EAF, and INFO
  • flags malformed rows, low-information variants, duplicate variant identifiers, and ambiguous palindromic SNPs
  • writes a flagged TSV plus a JSON summary with top hits and recommended downstream tools

When To Use It

  • when you need a reusable starter for gwas beyond a notes-only frontier placeholder
  • when a dataset needs fast summary-statistics QC before LDSC, fine-mapping, PRS, or interpretation work
  • when you want a stable local contract that does not depend on large reference panels or remote services

Run

python3 skills/genomics/gwas-starter/scripts/run_gwas_summary_qc.py \
  --input skills/genomics/gwas-starter/examples/toy_sumstats.tsv \
  --config skills/genomics/gwas-starter/examples/qc_config.json \
  --out-tsv scratch/gwas/gwas_qc.tsv \
  --summary-out scratch/gwas/gwas_qc_summary.json

Notes

  • The starter is intentionally local and deterministic. It surfaces issues that should be resolved before genome-wide downstream tools consume the file.
  • Header normalization supports common aliases such as CHR, BP, EA, NEA, BETA, OR, P, N, EAF, and INFO.
  • For allele harmonization against reference genomes, SSF export, or LD-based follow-up, read refs.md and use the cited canonical tools.
Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 4d ago First seen · 33 lines · 0 tokens per session scan A 9663ed6ae7fc

Subscribe to this mod's changes

gwas-starter is a skill published in the GitHub repository ma-compbio-lab/SkillFoundry (38 stars, last pushed 4mo ago), licensed Apache-2.0. It costs nothing until one of its globs matches a file; then it loads 397 tokens. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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