bulkrna-de

bulkrna-de is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 54 tokens per session (815 once invoked), scanned A, original, Apache-2.0.

A workflow for comparing gene activity between two groups using bulk RNA sequencing count data. It identifies genes whose measured expression differs between conditions such as treatment and control.

In plain words
What is it for?
Use it with a gene-by-sample count table to produce differential-expression results, significant-gene tables, quality plots, and a report.
Why use it?
It applies statistical testing and false-discovery correction so differences are easier to assess than by comparing raw counts alone.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it with a gene-by-sample count table to produce differential-expression results, significant-gene tables, quality plots, and a report.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/bulkrna-de
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill bulkrna-de
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bulkrna-de

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-de/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-de)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-de"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-de/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for bulkrna-de

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-de"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-de.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 54 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 815 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00054 $0.00815
Opus 5.5 $0.00022 $0.00326
Sonnet 5.5 $0.00011 $0.00163
Haiku 4.5 $0.00005 $0.00081

Measured 17d ago against content hash 7bfb81708985, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

bulkrna-de scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 17d ago.

The scan reads SKILL.md. This mod also ships 6 executable files (_api.py, bulkrna_de.py, examples/example_step.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/bulkrna/bulkrna-de/SKILL.md · 79 lines

How it starts

The opening of the file, as written. The whole thing — 79 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Bulk differential expression

Purpose

Compare two prefix-selected groups in a raw count matrix. The default backend is R DESeq2; --method ttest selects Welch tests. The R bridge applies apeglm or ashr shrinkage when installed, otherwise raw estimates. This is not a single-cell or splicing analysis.

Inputs & Outputs

CLI input is a gene-first CSV. The library takes a gene-indexed DataFrame. Both require nonnegative integer counts. Outputs include tables/de_results.csv, tables/de_significant.csv, four diagnostic figures, report.md and result.json; DESeq2 intermediate tables are backend-dependent.

API

differential_expression(counts, *, method='deseq2', control_prefix='ctrl', treat_prefix='treat', padj_cutoff=0.05, lfc_cutoff=1.0, min_count=10)

Compare treatment against control without changing the count matrix.

:param counts: Gene-indexed DataFrame of nonnegative integer raw counts. :param method: CLI default deseq2 (R); ttest selects Welch tests. :param control_prefix: CLI default ctrl selects control columns. :param treat_prefix: CLI default treat selects treatment columns. :param padj_cutoff: CLI default 0.05; significance requires a smaller adjusted p. :param lfc_cutoff: CLI default 1.0; absolute log2 effect must exceed it. :param min_count: Legacy filtering default 10 for total counts across selected samples. :returns: DE DataFrame with effect estimates, p values and run diagnostics in attrs. :raises ValueError: Counts, method, groups or thresholds are invalid. :raises ImportError: R DESeq2 is missing; use install_skill_deps for DESeq2.

run_info(result, *, keep=True)

Read filtering, group and executed-method diagnostics.

:param result: DataFrame returned by differential_expression. :param keep: Default True; False removes diagnostics from attrs. :returns: Diagnostic dictionary, empty after removal.

volcano_figure(result)

Plot reported log2 effects and adjusted significance.

Read the full file on GitHub · 79 lines

Files

What ships with it

9 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 17d ago Changed · -17 lines 7bfb81708985
  2. 1mo ago First seen · 96 lines · 54 tokens per session scan A a603e0e81588

Subscribe to this mod's changes

bulkrna-de is a skill published in the GitHub repository TianGzlab/OmicsClaw (161 stars, last pushed 17d ago), licensed Apache-2.0. It adds 54 tokens to every session and 815 once invoked, about $0.0002 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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